Influence of Cephalosporins on Humoral Immune Response

Gillissen, G

doi:10.1007/978-3-642-68670-2_2

Cited by 10 publications

(3 citation statements)

References 8 publications

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“…Additionally, these par ticular cephalosporins showed no effect on host resistance to P. yoelii, indicating that mice repeatedly treated with high doses of these antibiotics retain the capacity to mount a sustained multicomponent immune response, which requires both T cell and B cell compe-tcnce including a T-ccll-depcndent IgG pro tective antibody response [13]. Increased lev els of IgM have also been reported following treatment with cefaclor [16]. This antibiotic caused nonspecific proliferation of IgM-producing cells in the spleen followed by polyclo nal serum IgM production.…”

Section: Discussionmentioning

confidence: 99%

“…Undoubtedly, drug-host immune system interactions can also be critical to the successful resolution of bacterial infection [1,2], The reported effects of various cephalosporin antibiotics on im mune parameters are not consistent and in clude reports of both stimulation and suppres sion of immune function. Further, there are differences in behavior among derivatives be longing to the same family of antibiotics [3,4). Recently, we reported that repeated injec tions with a high dose (800 mg/kg/day) of ceftezole, one of six cephem antibiotics tested in mice, resulted in splenomegaly induced by the proliferation of IgM plaque-forming cells lo cated in the splenic germinal centers, and an associated increase in total serum IgM levels, without increase in total serum IgG levels [5], However, the biological relevance of these changes has not been established.…”

Section: Introductionmentioning

confidence: 99%

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Immunotoxicity of Cephalosporins in Mice

Furuhama

Bj³

et al. 1993

Chemotherapy

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This study was performed in female B6C3F1 mice to confirm previously observed effects of selected cephalosporin antibiotics on nonspecific immunity, and to determine possible effects on specific acquired immunity and host resistance. Mice were treated intravenously with DQ-2556, ceftizoxime or ceftezole at 800 mg/kg/day for 3, 5, or 7 consecutive days. All three compounds increased total serum IgM levels from day 3, but had no effects on total serum IgG levels and the thymus weight. All three cephalosporin antibiotics caused a slight increase in spleen weight and splenic germinal centers were enlarged after 5- or 7-day treatments. Antibody responses to type III pneumococcal polysaccharide (S3), a T-cell-independent immunogen, and sheep red blood cells (SRBC), a T-cell-dependent immunogen, were slightly decreased after 5-day dosings with each compound, and reached significance in DQ-2556 (response to S3) and ceftizoxime (response to S3 and SRBC). None of the tested cephalosporin antibiotics altered delayed-type hypersensitivity to oxazolone or host resistance to Plasmodiumyoelii, indicating that the antibiotic-treated mice retained the capacity to mount a multicomponent and sustained protective immune response. These data suggest that although cephalosporins may cause polyclonal expansion of B cells with associated increases in total serum IgM, they do not affect the tested measures of cell-mediated immunity or host resistance. The decreased IgM antibody responses to S3 and SRBC are associated with but not known to be causally related to the concurrent IgM hypergammaglobulinemia.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Immunotoxicity of Cephalosporins in Mice

Furuhama

Bj³

et al. 1993

Chemotherapy

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“…This is specially interesting when antibiotics are given to immunosuppressed patients. The capacity to modify the immune response to unrelated antigens has been observed with numerous antibiotics, including ␤-lactams (8,19), aminoglycosides (19), tetracyclines (10), rifamycins (2), and others.…”

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confidence: 99%

Modification of immune response in mice by ciprofloxacin

Jiménez-Valera

Sampedro

Moreno

et al. 1995

Antimicrob Agents Chemother

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Some studies have suggested that the addition of ciprofloxacin to in vitro cultures of mitogen-stimulated lymphocytes exerts inhibitory effects on cell cycle progression and immunoglobulin (Ig) secretion. We tested the effects of this drug on some immunity parameters in BALB/c mice. Mice treated intraperitoneally with ciprofloxacin (10 mg/kg of body weight per day) for 3 consecutive days and immunized with sheep erythrocytes 24 h after the last injection showed significant suppression of hemolytic IgG-forming cells, whereas the response of IgM-forming cells remained unchanged. When treatment lasted 7 days the response of antibodyforming cells was not modified. When the 3-day treatment was started at 24 h after immunization with sheep erythrocytes, the response of IgM-forming cells was increased, whereas the response of IgG-forming cells was suppressed. Delayed-type hypersensitivity to sheep erythrocytes was significatively suppressed in animals that received the 3-day treatment with ciprofloxacin and were immunized subcutaneously 24 h after the last injection. In vitro proliferation of lymphocytes from ciprofloxacin-treated mice in response to either lipopolysaccharide or concanavalin A was also suppressed. Leukopenia and an increase in the level of granulocytemacrophage colony-forming cells in bone marrow were also observed in ciprofloxacin-treated mice. These results, together with those from other reports, suggest that modification of the biological responses by ciprofloxacin is a complex phenomenon that may be influenced by several factors.The knowledge of possible influences of antibiotics on the immune response seems to be of great importance for the clinical approach to the process of therapy. This is specially interesting when antibiotics are given to immunosuppressed patients. The capacity to modify the immune response to unrelated antigens has been observed with numerous antibiotics, including ␤-lactams (8, 19), aminoglycosides (19), tetracyclines (10), rifamycins (2), and others.The fluoroquinolones are antimicrobial agents with a broad antimicrobial spectrum (21). The primary target of fluoroquinolones is the bacterial DNA gyrase (topoisomerase II) (21). However, some inhibitory effects of these agents on the eucaryotic enzymes involved with DNA replication have been observed (9). A number of quinolones have been shown to possess genotoxicity in vitro, and this has been considered a possible explanation for some of the abnormal eucaryotic cellular responses obtained after treatment with these agents (9). Some of these effects have been observed on leukocytes. It has been found that ciprofloxacin penetrates leukocytes and reaches intracellular levels with bactericidal activity (4,20). The incorporation of [ 3 H]thymidine into T lymphocytes incubated with phytohemagglutinin was increased in the presence of fluoroquinolones, but the progression of mitogen-stimulated lymphocytes through the S and G 2 /M stages of the cell cycle and the secretion of immunoglobulins (Ig's) by pokeweed mitogen-stimulated B ...

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