Influence of Chemical Extraction on Rheological Behavior, Viscoelastic Properties and Functional Characteristics of Natural Heteropolysaccharide/Protein Polymer from Durio zibethinus Seed

Amid, Bahareh Tabatabaee; Mirhosseini, Hamed

doi:10.3390/ijms131114871

Cited by 16 publications

(4 citation statements)

References 48 publications

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“…Generally, gums exert their optimum functionality when sufficiently dissolved or hydrated in water [ 71 ]. All the water absorptive parameters (except distilled water) increased with increasing pH of the medium, suggesting disintegration and drug retention functional potentials of this gum when present in a solid dosage formulation.…”

Section: Resultsmentioning

confidence: 99%

Physicochemical and Microbiological Characteristics of Stem Bark Exudate Gum of Cordia millenii Tree in Conventional Release Tablets

Kipo

Ofori-Kwakye

Kuntworbe

et al. 2023

The Scientific World Journal

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The development of a raw material into an acceptable pharmaceutical excipient involves evaluation of the physicochemical and formulation properties of the potential raw material. Results from these evaluations may serve as a guide to subsequent use of the substance. The objective of the study was to evaluate the physicochemical and microbiological properties of the stem bark gum of Cordia millenii tree in conventional release paracetamol tablets. From the physicochemical evaluations, the gum was slightly acidic and soluble in all the aqueous-based solvents, except 0.1 N HCl in which it was sparingly soluble. All the absorptive properties of the gum indicated tablet disintegrating potential for tablet formulation. The total ash of the gum was higher than that of the international standard gum arabic. Micromeritic properties of the gum indicated the need for a flow aid to improve its flowability. There were no harmful microorganisms detected in the gum. Aerobic organisms and moulds and yeast were detected within permissible limits. Tablets formulated using six different concentrations of gum dispersions as a binder were generally soft and failed the USP T80 standard of dissolution, indicating poor binding and drug releasing properties. Quality control properties of three different batches of tablets containing varying concentrations of the dry gum as a disintegrating agent were comparable to tablets containing equal concentrations of corn starch. The in vitro drug releases were similar at all-time points of drug evaluation. The gum can therefore be considered as a good disintegrant in the formulation of conventional release tablets.

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Section: Resultsmentioning

confidence: 99%

Physicochemical and Microbiological Characteristics of Stem Bark Exudate Gum of Cordia millenii Tree in Conventional Release Tablets

Kipo

Ofori-Kwakye

Kuntworbe

et al. 2023

The Scientific World Journal

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“…Gums may be derived from different sources, mainly leaves, bark, and seeds ( Amiri et al, 2021 ) . Amine et al (2007) extracted gum from durian seed, then this method was adjusted where the chemical compositions of durian seed-derived gums, and their rheological and viscoelastic behavior were characterized ( Amid and Mirhosseini, 2012 ). Gum possesses diverse properties of attracting water giving them high viscosity and swelling properties and its ability to form a biofilm ( Mohammadinejad et al, 2020 ).…”

Section: Plant Seed Extracts As Potential Source For Biomedical Scaff...mentioning

confidence: 99%

“…Recently, physicochemical, and functional characteristics have been studied in various plant gums where they perform many structural applications. The gum was extracted from Cassia javanica , Caesalpinia pulcherrima ( Singh et al, 2009 ), mucilage from Linum usitatissimum L. seeds ( Warrand et al, 2005 ) and gum from Mesquite seed ( Estévez et al, 2004 ), besides functional properties and rheology of the biopolymer from the heteropolysaccharide and protein from Durio zibethinus seed were studied ( Amid and Mirhosseini, 2012 ).…”

Section: Plant Seed Extracts As Potential Source For Biomedical Scaff...mentioning

confidence: 99%

Emerging applications of 3D engineered constructs from plant seed extracts

Odabaş¹,

Gari̇pcan²,

Ksouri³

2023

Turkish Journal of Biology

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Seeds, by-products derived from various plants such as mango, quince, and apples, are considered waste, though they have emerging commercial potential, and have been used in biological, industrial, and physiological research. Seed-derived natural macromolecules— mainly polysaccharides, mucilage, gums, and cellulose—have physicochemical and structural diversification, giving the potential for forming gels, texturing, thickening, and providing interfacial adsorption. Seed-derived natural macromolecules have been widely used during the last few years in cell research and tissue engineering applications. Their widespread approachability and safety, high rate of biodegradability, biocompatibility, supporting cell proliferation, and extracellular matrix synthesis are the main properties making plant seed derivatives appropriate for use. The gel-forming ability of these derivatives gives them the capability of creating natural polymer-based scaffolds with the aptitude to resemble extracellular matrices (ECM). These ECM exhibit the high potential in scaffolds for tissue renewal. A deeper knowledge of the physicochemical characteristics of seed-derived mucilage and gum has been indicated as a key ingredient in several pharmaceutical preparations, but it has been remarkably utilized in nanomedicine for the last few years as a drug carrier for drug delivery, in gene therapy, and as scaffold components for tissue engineering purposes. Here, we afford up-to-date data about the different extracts from plant seeds—mainly mucilage and gum, we summarize the extraction techniques used to isolate these macromolecules, and we focus on their application in scaffold fabrication for tissue engineering purposes and regenerative medicine applications.

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“…Polysaccharides can be classified according to their electric charge: cationic polysaccharide [ 6 ] (chitin, chitosan), anionic polysaccharide [ 7 , 8 ] (heparin, hyaluronic acid, alginic acid and chondroitin sulfate) and nonionic polysaccharide [ 9 ] (dextran, starch, and cellulose). In terms of chemical composition, polysaccharides can also be classified as the homo-polysaccharide [ 10 ] containing a single type of monosaccharide and hetero-polysaccharide [ 11 ] containing two or more different types of monosaccharides. For example, cellulose consists of unique glucose and heparin consists of the α- l -idopyranosyluronic acid 2-sulfate and 2-deoxy-2-sulfoamino-α- d -glucopyranose 6-sulfate [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

Bioactive polysaccharides from natural resources including Chinese medicinal herbs on tissue repair

et al. 2018

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BackgroundFunctional polysaccharides can be derived from plants (including herbs), animals and microorganisms. They have been widely used in a broad of biomedical applications, such as immunoregulatory agents or drug delivery vehicles. In the past few years, increasing studies have started to develop natural polysaccharides-based biomaterials for various applications in tissue engineering and regenerative medicine.Main bodyWe discuss in this article the emerging applications of natural polysaccharides—particularly those derived from Chinese medicine—for wound healing. First, we introduce natural polysaccharides of three natural sources and their biological activities. Then, we focus on certain natural polysaccharides with growth factor-binding affinities and their inspired polymeric tools, with an emphasis on how these polysaccharides could possibly benefit wound healing. Finally, we report the latest progress in the discovery of polysaccharides from Chinese medicinal herbs with identified activities favouring tissue repair.ConclusionNatural polysaccharides with clearly elucidated compositions/structures, identified cellular activities, as well as desirable physical properties have shown the potential to serve as therapeutic tools for tissue regeneration.

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Influence of Chemical Extraction on Rheological Behavior, Viscoelastic Properties and Functional Characteristics of Natural Heteropolysaccharide/Protein Polymer from Durio zibethinus Seed

Cited by 16 publications

References 48 publications

Physicochemical and Microbiological Characteristics of Stem Bark Exudate Gum of Cordia millenii Tree in Conventional Release Tablets

Physicochemical and Microbiological Characteristics of Stem Bark Exudate Gum of Cordia millenii Tree in Conventional Release Tablets

Emerging applications of 3D engineered constructs from plant seed extracts

Bioactive polysaccharides from natural resources including Chinese medicinal herbs on tissue repair

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