Influence of cholecystokinin octapeptide sulfate ester on brain monoamine metabolism in rats

Fekete, M.; Kádár, Tibor; Penke, Botond; Kovács, K.; Telegdy, Gyula

doi:10.1007/bf01249131

Cited by 76 publications

(10 citation statements)

References 19 publications

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“…The i.c.v, injection of CCK has been reported to have little influence on the serotonin content in the brain (Fekete et al, 1981;Mashal and Hunt, 1983), although some CCK-8 immunoactive neurons in the medulla oblongata contain serotonin (Mantyh et al, 1984). Although the effects of CCK-8 on monoamines have been well investigated (Fekete etal., 1981), there are few reports about the change in CCK-8 level caused by serotonin depletion.…”

Section: Discussionmentioning

confidence: 97%

Regional changes in neuropeptide levels after 5,7-dihydroxytryptamine-induced serotonin depletion in the rat brain

Kondo

Ogawa²,

Asanuma³

et al. 1993

J. Neural Transmission

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The levels of five neuropeptides (substance-P, somatostatin, cholecystokinin octapeptide, methionine-enkephalin and dynorphin) were examined in the brain and the spinal cord of rats 2 weeks after intracerebroventricular injection of 5,7-dihydroxytryptamine (5,7-DHT). 5,7-DHT injection caused a significant reduction of the serotonin level in all regions of the brain. The level of each neuropeptide except dynorphin significantly increased in specific regions of the brain after 5,7-DHT treatment without any decrease in their levels in any region. Since, coexistence and interaction between classical neurotransmitters and neuropeptides in the same neurons have been reported, both are indispensable for evaluating pathophysiological state of the brain function associated with abnormal neural transmission. The present findings together with previous reports suggest that neuropeptides act as neurotransmitters and compensate for the impaired function of the serotonergic systems.

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Section: Discussionmentioning

confidence: 97%

Regional changes in neuropeptide levels after 5,7-dihydroxytryptamine-induced serotonin depletion in the rat brain

Kondo

Ogawa²,

Asanuma³

et al. 1993

J. Neural Transmission

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“…These data strongly suggest that the peptide has no direct action on the pitu itary and probably acts at the hypothalamic level. Indeed, the modifications in mono amine (decrease in dopamine and serotonin and increase in norepinephrine) turnover, observed in the hypothalamus of rats treated with CCK-8 [11], can account for the hor monal changes observed in the present inves tigation. Moreover, recently the coexistence of dopamine and a CCK-like peptide in brain neurons has been demonstrated [39].…”

Section: Discussionmentioning

confidence: 70%

Effect of Caerulein on Pituitary Response to TRH in Humans

Scarpignato¹,

Pezzetta²,

Tarditi³

1986

Horm Res

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The effect of caerulein (100 ng/kg/h × 1 h) on basal as well as on thyrotropin-releasing hormone (TRH)-stimulated prolactin and thyroid-stimulating hormone (TSH) secretion was studied in healthy male volunteers. The peptide did not change the basal levels of prolactin and TSH. However, during the infusion of caerulein, prolactin response to TRH was significantly increased whereas the TSH response was decreased. These data, showing an action of caerulein (a frog peptide which mimics the biological actions of cholecystokinin) on prolactin and TSH release, suggest that cholecystokinin may be involved in the physiological control of human pituitary secretion.

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“…First, if it is admitted that DA neurons, i.e., those which possibly terminate in the MPO, stimulate LHRH neurons to secrete LHRH, either directly or indi rectly, CCK-8-S will exert a certain stimulatory effect on this DA action. It was shown that intraventricular adminis tration of CCK-8-S increased DA turnover in the striatum, although it decreased the turnover in other areas [8]. In the substantia nigra and ventral tegmental area, CCK excited the electrical activity of the DA cell [25].…”

Section: Discussionmentioning

confidence: 99%

“…In fact, a number of investigations have found pharmacological [7,8], electrophysiological [25] and bio chemical [18] interactions between CCK and DA systems.…”

Section: Introductionmentioning

confidence: 99%

Inhibition of Gonadotropin Secretion Induced by Cholecystokinin Implants in the Medial Preoptic Area by the Dopamine Receptor Blocker, Pimozide, in the Rat

Hashimoto¹,

Kimura²

1986

Neuroendocrinology

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We have shown that the implantation of cholecystokinin octapeptide sulfated form (CCK-8-S) or dopamine (DA) in the medial preoptic area (MPO) in ovariectomized estrogen-primed rats induced an enhancement of the afternoon rise in LH secretion. The present study was done to examine the possible functional interaction of both substances in the brain. Two groups of ovariectomized estradiol (5 µg, s.c.)-primed rats were administered intraperitoneally either pimozide (1 mg/kg BW; pimozide-treated group) or 0.1 M tartaric acid as the control solution (pimozide-untreated group). CCK-8-S or DA was implanted in the MPO through chronically implanted guide cannulae and the effects on serum LH and FSH concentrations were compared between both groups. An empty cannula was used as the control. Implantation of either CCK-8-S or DA in the pimozide-untreated group induced marked enhancements of afternoon rises in LH and FSH levels, which normally occurred, but with a lesser magnitude in the animals with the empty cannula. In the pimozide-treated group, however, neither CCK-8-S nor DA induced changes in the LH and FSH levels. It was evident that both effects of CCK-8-S and DA on LH and FSH secretion were blocked by pretreatment with the DA receptor blocker. These data indicate that DA receptors are required to be intact when CCK-8-S implants manifest their action in stimulating gonadotropin secretion.

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Influence of cholecystokinin octapeptide sulfate ester on brain monoamine metabolism in rats

Cited by 76 publications

References 19 publications

Regional changes in neuropeptide levels after 5,7-dihydroxytryptamine-induced serotonin depletion in the rat brain

Regional changes in neuropeptide levels after 5,7-dihydroxytryptamine-induced serotonin depletion in the rat brain

Effect of Caerulein on Pituitary Response to TRH in Humans

Inhibition of Gonadotropin Secretion Induced by Cholecystokinin Implants in the Medial Preoptic Area by the Dopamine Receptor Blocker, Pimozide, in the Rat

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