Influence of Cholinergic Receptor Blockade on Drug-Induced Prolactin Release in the Monkey

Gala, Richard R.; Subramanian, Marappa G.; Peters, Judith C.; Jaques, Sandford

doi:10.1159/000178719

Cited by 24 publications

(6 citation statements)

References 17 publications

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“…Monkey samples were assayed at monthly intervals using the human prolactin RIA. This assay has been validated in our laboratory for the determination of monkey serum prolactin (Gala Se Jaques 1975). Variability between assays was approximately 14°/o and variation within an assay was approximately 8°/o.…”

Section: Monkeysmentioning

confidence: 99%

Lack of a Circannual Cycle of Daytime Serum Prolactin in Man and Monkey

Rr¹,

C²,

Wh³

et al. 1977

Acta Endocrinologica

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Serum samples were obtained from 7 subjects (6 men and 1 woman) in the morning (09.00 h) and in the afternoon (15.00 h) of each week for a period of 13 months and assayed for prolactin by RIA. In addition, 4 female monkeys were sampled once weekly in the afternoon for approximately two years. The data were analyzed for cyclicity by power spectrum analysis. In both species a serum prolactin circannual cycle was not obvious. In most subjects statstically significant (P<0.05) cycles were observed; however, there was considerable variability among individuals in the duration of the cycle, which ranged between 4 and 50 weeks. A similar result was also observed for the monkey data; here the cycles ranged between 7 and 51 weeks. The physiologic significance of these cycles is unknown at present. It is suggested that although there appears to be no diurnal serum prolactin circannual cycle, this does not rule out the possibility that there may be a nocturnal circannual cycle.An annual alteration in reproductive capacity and behaviour has been appre¬ ciated for a number of years in animals under natural conditions (Asdell 1946). The advent of sensitive and specific radioimmunoassays enabled in-

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Section: Monkeysmentioning

confidence: 99%

Lack of a Circannual Cycle of Daytime Serum Prolactin in Man and Monkey

Rr¹,

C²,

Wh³

et al. 1977

Acta Endocrinologica

Self Cite

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“…Stairs Memorial Fund, McGill University and Merck Frosst Labora tories, PQ, Canada. 1975;Gala et al, 1976;Suhramanian and Gala, 1976;McLean and Nikitovitch-Winer, 1975), less information is available in man.…”

Section: Introductionmentioning

confidence: 99%

Effect of Benztropine on Haloperidol-Induced Prolactin Secretion

Lal¹,

Mendis²,

Cervantes³

et al. 1979

Neuropsychobiology

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The effect of benztropine on haloperidol-induced prolactin secretion was investigated in 10 normal male volunteers. Benztropine had no effect on basal prolactin secretion but significantly enhanced the increase induced by haloperidol. The magnitude of the enhancement, however, was relatively small. These data suggest that in man cholinergic mechanisms have no effect on basal prolactin secretion but exert a weak inhibitory effect under conditions of dopamine receptor blockade. Differences in intrinsic anticholinergic properties may account for some of the variations in potency of different neuroleptics in increasing circulating prolactin concentrations.

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“…In rats, intraperitoneal injections of pilocarpin were without effect on basal prolactin secretion (Muraki et al 1979). Atropine and propantheline bromide, 2 parasympatholytic agents, do not change basal prolactin levels in humans (Bizzarro et al 1980;Davis et al 1983;Gala et al 1976), whereas TRH-stimulated prolactin release can be diminished. Atropine and propantheline bromide, 2 parasympatholytic agents, do not change basal prolactin levels in humans (Bizzarro et al 1980;Davis et al 1983;Gala et al 1976), whereas TRH-stimulated prolactin release can be diminished.…”

Section: Parasympathomimetics and Parasympatholyticsmentioning

confidence: 99%

Drug-Induced Changes in Prolactin Secretion

Hell

Wernze

1988

Medical Toxicology

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Prolactin secretion is affected by various diseases as well as by many drugs in humans and animals. While marked hyperprolactinaemia suggests the presence of a pituitary tumor, moderate changes may also occur in various endocrine or non-endocrine disorders. Drugs can interfere with prolactin regulation via complex mechanisms at the hypothalamus or at the pituitary site, but possible changes in prolactin metabolism are poorly understood as yet. This survey of the literature up to June 1986 covers the influence of various groups of drugs and agents on the plasma prolactin level under various conditions. It contains information that will facilitate evaluation of whether hyper- or hypoprolactinaemia may result from therapeutic intervention or must be related to an underlying disease. It is obvious that more subtle changes can be revealed by the use of dynamic tests either to stimulate or to suppress prolactin secretion.

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Influence of Cholinergic Receptor Blockade on Drug-Induced Prolactin Release in the Monkey

Cited by 24 publications

References 17 publications

Lack of a Circannual Cycle of Daytime Serum Prolactin in Man and Monkey

Lack of a Circannual Cycle of Daytime Serum Prolactin in Man and Monkey

Effect of Benztropine on Haloperidol-Induced Prolactin Secretion

Drug-Induced Changes in Prolactin Secretion

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