Influence of Cholografin and Renografin 76 on Platelet Function

Shapiro, Gabriel A.; Loeb, Peter M.; Berk, Robert N.; Manton, J.; Ellzey, Barbara; Reynolds, David G.

doi:10.1148/124.3.641

Cited by 24 publications

(5 citation statements)

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“…(23), SHAPIRO et coll. (18) and COGAN et coll, (4) using aggregometers, whereas FRITZLER et coIl. (5) found platelet aggregation by electron microscopy.…”

Section: Discussionmentioning

confidence: 99%

Selective Nephroangiography in the Dog Causing Renal Platelet Aggregation and Irregular Nephrographic Phase

Almén¹,

Bergentz²,

Törnquist³

et al. 1985

Acta Radiologica. Diagnosis

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Selective renal artery injections of large single doses of the ionic contrast medium metrizoate produced an irregular nephrographic phase, 'patchy contrast medium retention', in 14 of 16 dogs. The irregular nephrographic phase was associated with a transient accumulation of platelets and fibrinogen in the kidney and with microscopically demonstrable transient thrombi in afferent arterioles and glomerular capillary tufts. These effects were followed by tubular damage, which was demonstrated in 4 of 6 dogs examined 48 hours after injection. Formation of thrombi was not demonstrated in 6 dogs given small single doses, which produced a homogeneous nephrographic phase. It is suggested that contrast medium induced endothelial damage is a pathogenetic mechanism in the development of thrombi and patchy contrast medium retention.

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“…(23), SHAPIRO et coll. (18) and COGAN et coll, (4) using aggregometers, whereas FRITZLER et coIl. (5) found platelet aggregation by electron microscopy.…”

Section: Discussionmentioning

confidence: 99%

Selective Nephroangiography in the Dog Causing Renal Platelet Aggregation and Irregular Nephrographic Phase

Almén¹,

Bergentz²,

Törnquist³

et al. 1985

Acta Radiologica. Diagnosis

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“…[ l ] However, there are several reports of inhibition by contrast agents of platelet aggregation, [3-111 while Verdirame et al [12] and Shapiro et al [13] found no effects.…”

Section: Introductionmentioning

confidence: 99%

Radiographic contrast agents and platelet function: A quenched‐flow study

Taylor

Angello

Ayers

et al. 1991

Cathet. Cardiovasc. Diagn.

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Radiographic contrast media (RCM) may alter platelet behavior at concentrations achieved during cardiac angiography. We used quenched-flow aggregometry coupled to single-particle counting to study the influence of RCM on the kinetics of platelet aggregation (less than 5.0 sec) induced by adenosine diphosphate (ADP, 2.86 microM). At a concentration in platelet-rich plasma (PRP) of 5 per cent RCM by volume, platelet aggregation was inhibited by diatrizoate, iopamidol and ioxaglate either directly or following incubation of each contrast agent with PRP for 20 minutes. Diatrizoate inhibited more than did iopamidol or ioxaglate (56 +/- 6, versus 39 +/- 3 and 40 +/- 9 per cent respectively; P less than 0.003, p less than 0.009, n = 20 normal subjects). A small reduction (about 16 per cent) in aggregation velocity occurred within 5 seconds of exposure of PRP to all 3 RCM and the onset time (t) or lag period before aggregation begins was significantly prolonged by diatrizoate (p less than 0.03). The RCM vehicles alone (iodinated moiety removed, osmolality readjusted) had no effect on the ADP-induced aggregation. Platelet counts fell significantly after incubation with diatrizoate (12%; p = 0.04). Our data therefore show that early platelet aggregation was inhibited by 3 commonly-used ionic and nonionic contrast agents. Inhibition was apparently caused by the iodinated contrast molecule, began within seconds of platelet-RCM contact and was independent of vehicle composition. Since diatrizoate inhibited aggregation more than iopamidol or ioxaglate, its use may be of additional value during angiographic procedures in clinical situations involving enhanced platelet activation.

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“…Platelet function expressed as the contact activation has been reported to be little affected by Renografin 60 ex vivo [7]. Another report showed that Cholografin and Renografin 76 had significant platelet inhibitory effects in vitro [8], but the author noted the in vivo inhibitory effect only at high levels of plasma contrast agents. In a recent experimental study, Motomiya et al [9] found that rabbits that received 10 ml of Urografin 76 demonstrated a transient decrease in platelet aggregation for at least 3 min.…”

Section: Discussionmentioning

confidence: 99%

Severe thrombocytopenia as a result of contrast left ventricular angiography

Wein

Handler

Chadda

1982

Cathet. Cardiovasc. Diagn.

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A case report of a 29-year-old Hispanic male who developed an acute thrombocytopenic reaction immediately following a cardiac catheterization using Hypaque-M radiographic dye. Laboratory studies immediately post-catheterization revealed a platelet count of 11,000 with a subsequent further drop to a low of 4,000. A need for the prompt identification and possible causes of this unusual reaction are discussed. Recovery occurred following treatment with corticosteroids.

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Influence of Cholografin and Renografin 76 on Platelet Function

Cited by 24 publications

References 0 publications

Selective Nephroangiography in the Dog Causing Renal Platelet Aggregation and Irregular Nephrographic Phase

Selective Nephroangiography in the Dog Causing Renal Platelet Aggregation and Irregular Nephrographic Phase

Radiographic contrast agents and platelet function: A quenched‐flow study

Severe thrombocytopenia as a result of contrast left ventricular angiography

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