Influence of Chondroitin Sulfate and Hyaluronic Acid Presence in Nanofibers and Its Alignment on the Bone Marrow Stromal Cells: Cartilage Regeneration

Lee, Paul; Tran, Katelyn; Chang, Wei; Shelke, Namdev B.; Kumbar, Sangamesh G.; Yu, Xiaojun

doi:10.1166/jbn.2014.1831

Cited by 58 publications

(54 citation statements)

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“…This opened up avenues for tissue regeneration; with researchers hypothesizing that scaffolds could potentially provide structural stability and environment for cellular regeneration thus mimicking native tissue in functionality. Since then, 3D scaffolds have been evaluated for a wide variety of applications ranging from bone regeneration, nerve regeneration, muscle regeneration, tendon/ligament regeneration, and much more [2–4]. To accomplish these scaffolds, synthetic and natural polymers have been popular biomaterials due in large part to their vast diversity of properties and bioactivity [5–7].…”

Section: Introductionmentioning

confidence: 99%

Bioactive polymeric scaffolds for tissue engineering

Stratton

Shelke

Hoshino

et al. 2016

Bioactive Materials

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A variety of engineered scaffolds have been created for tissue engineering using polymers, ceramics and their composites. Biomimicry has been adopted for majority of the three-dimensional (3D) scaffold design both in terms of physicochemical properties, as well as bioactivity for superior tissue regeneration. Scaffolds fabricated via salt leaching, particle sintering, hydrogels and lithography have been successful in promoting cell growth in vitro and tissue regeneration in vivo. Scaffold systems derived from decellularization of whole organs or tissues has been popular due to their assured biocompatibility and bioactivity. Traditional scaffold fabrication techniques often failed to create intricate structures with greater resolution, not reproducible and involved multiple steps. The 3D printing technology overcome several limitations of the traditional techniques and made it easier to adopt several thermoplastics and hydrogels to create micro-nanostructured scaffolds and devices for tissue engineering and drug delivery. This review highlights scaffold fabrication methodologies with a focus on optimizing scaffold performance through the matrix pores, bioactivity and degradation rate to enable tissue regeneration. Review highlights few examples of bioactive scaffold mediated nerve, muscle, tendon/ligament and bone regeneration. Regardless of the efforts required for optimization, a shift in 3D scaffold uses from the laboratory into everyday life is expected in the near future as some of the methods discussed in this review become more streamlined.

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Section: Introductionmentioning

confidence: 99%

Bioactive polymeric scaffolds for tissue engineering

Stratton

Shelke

Hoshino

et al. 2016

Bioactive Materials

Self Cite

380

225

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“…In conclusion, to the best of our knowledge, few reports focused on the effect of ECM-derived biomaterials in cartilage regeneration (Jin et al, 2007; Yang et al, 2008; Baugé et al, 2014; Grogan et al, 2014; Lee et al, 2014; Youngstrom et al, 2015) and in any case the combination with alginate properties has not been described. This interaction is an essential feature for the success of a TE strategy, allowing to maintain the low friction and the load-bearing characteristics of the native cartilage (Moutos and Guilak, 2008; Grogan et al, 2014).…”

Section: Discussionmentioning

confidence: 90%

Dedifferentiated Chondrocytes in Composite Microfibers As Tool for Cartilage Repair

Angelozzi

Penolazzi

Mazzitelli

et al. 2017

Front. Bioeng. Biotechnol.

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Tissue engineering (TE) approaches using biomaterials have gain important roles in the regeneration of cartilage. This paper describes the production by microfluidics of alginate-based microfibers containing both extracellular matrix (ECM)-derived biomaterials and chondrocytes. As ECM components gelatin or decellularized urinary bladder matrix (UBM) were investigated. The effectiveness of the composite microfibers has been tested to modulate the behavior and redifferentiation of dedifferentiated chondrocytes. The complete redifferentiation, at the single-cell level, of the chondrocytes, without cell aggregate formation, was observed after 14 days of cell culture. Specific chondrogenic markers and high cellular secretory activity was observed in embedded cells. Notably, no sign of collagen type 10 deposition was determined. The obtained data suggest that dedifferentiated chondrocytes regain a functional chondrocyte phenotype when embedded in appropriate 3D scaffold based on alginate plus gelatin or UBM. The proposed scaffolds are indeed valuable to form a cellular microenvironment mimicking the in vivo ECM, opening the way to their use in cartilage TE.

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“…Natural polymers, such as collagen [111], silk fibroin [140], fibrin [141], chondroitin sulfate, or hyaluronic acid [142], are often included in synthetic scaffolds to enhance chondrogenic differentiation. Of special interest in this context are self-assembling peptides, which are compatible with chondrocytes and do not require chemical or thermal treatment in order to form a scaffold [104,112,143].…”

Section: Tissue-engineered Constructsmentioning

confidence: 99%

Repair of Damaged Articular Cartilage: Current Approaches and Future Directions

Medvedeva

Grebenik

Gornostaeva

et al. 2018

IJMS

210

152

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Articular hyaline cartilage is extensively hydrated, but it is neither innervated nor vascularized, and its low cell density allows only extremely limited self-renewal. Most clinical and research efforts currently focus on the restoration of cartilage damaged in connection with osteoarthritis or trauma. Here, we discuss current clinical approaches for repairing cartilage, as well as research approaches which are currently developing, and those under translation into clinical practice. We also describe potential future directions in this area, including tissue engineering based on scaffolding and/or stem cells as well as a combination of gene and cell therapy. Particular focus is placed on cell-based approaches and the potential of recently characterized chondro-progenitors; progress with induced pluripotent stem cells is also discussed. In this context, we also consider the ability of different types of stem cell to restore hyaline cartilage and the importance of mimicking the environment in vivo during cell expansion and differentiation into mature chondrocytes.

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Influence of Chondroitin Sulfate and Hyaluronic Acid Presence in Nanofibers and Its Alignment on the Bone Marrow Stromal Cells: Cartilage Regeneration

Cited by 58 publications

References 0 publications

Bioactive polymeric scaffolds for tissue engineering

Bioactive polymeric scaffolds for tissue engineering

Dedifferentiated Chondrocytes in Composite Microfibers As Tool for Cartilage Repair

Repair of Damaged Articular Cartilage: Current Approaches and Future Directions

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