Influence of chronic carbon disulphide intoxication on the development of experimental atherosclerosis in rats.

Abstract

Rats fed on atherogenic diets containing 2% cholesterol and 0.5% cholic acid with or without 0.15% thiouracil were exposed to carbon disulphide (CS2) vapours (1 mg/l of air), five hours a day, six days a week for 6-10 months. Serum and aorta lipid contents were determined, and the extent of atherosclerotic changes was investigated. The following effects of chronic exposure to CS2 were found: (1) slower gain in body weight when rats were fed on atherogenic diet; (2) greater increase in serum cholesterol content (after thiouracil supplemented diet); (3) moderate increase in total cholesterol content in the aorta wall with a significantly increased esterified cholesterol fraction but none in phospholipid level in this tissue; and (4) more advanced lipid infiltrates of coronary arteries and endocardium, the latter predominantly in the aortic valves. These results together with data from previous studies indicate that metabolism of arterial lipids participates in the process of artheroma formation after chronic exposure to CS2 vapours.

Cross sectional observation of the effects of carbon disulphide on arteriosclerosis in rayon manufacturing workers.

“…[13][14][15][16][17][18][19][20][21][22][23] The biggest reason for this discrepancy may be the low level of exposure to CS 2 . Because the exposure concentration of CS 2 was low, and the study subjects were young, we need to trace any changes in their reaction to exposure to CS 2 for as long as possible to confirm the relation between exposure to CS 2 and arteriosclerosis.…”

Increased oxidative stress in subjects exposed to carbon disulfide (CS 2 ) - an occupational coronary risk factor

“…The increased CHD incidence related to the prolonged exposure to CS 2 was accompanied by a dyslipoproteinemia with increased total cholesterol, LDL-cholesterol, triglycerides and decreased HDL-cholesterol (Manu et al 1972, Wronska-Nofer et al 1990, Rudkowska et al 1978, Egeland et al 1992, Krstev et al 1992, Vanhoorne et al 1992. In experimental animals CS 2 was shown to induce disturbances in cholesterol synthesis and elimination of the products of cholesterol metabolism with bile (Wronska- Nofer 1969, WronskaNofer and Parke 1978, Wronska-Nofer et al 1980). It has been proposed that CS 2 -induced changes in cholesterol metabolism lead to the elevated level of cholesterol in blood and its deposition in the arterial wall , Lewis et al 1999.…”

Occupational exposure to low concentrations of carbon disulfide as a risk factor for hypercholesterolaemia

“…This observation supports the hypothesis of an etiologic role of CS 2 in the development of athero- Table 2 Blood pressure, total cholesterol and coronary heart disease (CHD) prevalence in the exposed and non-exposed groups (SBP systolic blood pressure, DPB diastolic blood pressure) sclerosis. Experimental studies indicated that CS 2 might have atherogenic eect [1,22,23,24]. Among the characteristic changes in metabolism, accompanying CS 2 intoxication, the authors classify changes in the lipid metabolism.…”