Influence of chronic hypomelatoninemia on carbohydrate and lipid metabolism of rats kept on western diet

Belikova, O. I.; Черно, В. С.; Frenkel, Yu. D.; Костенко, Віталій Олександрович

doi:10.15407/fz64.03.052

Cited by 5 publications

(10 citation statements)

References 13 publications

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“…Earlier, we demonstrated that the development of hypomelatoninaemia naturally occurs in rats due to long-term RCL exposure and does not manifest when the rats are kept on HFHLD. However, when these factors act together, the melatonin level is significantly reduced compared to the effects resulting from the separate use of the above-mentioned factors [ 7 ]. This confirms the ability of alimentary factors under certain conditions to influence melatonin secretion, which was discovered by other researchers [ 3 ].…”

Section: Discussionmentioning

confidence: 99%

“…Previously we have found out that the simultaneous effect of RCL and HFHLD leads to more marked metabolic disorders, such as LPO, and a decrease in the general antioxidant blood potential in the blood of rats, hyperinsulinaemia, hypo-α-lipoproteinaemia, hypertrialcylglycerolaemia, and increased visceral fat mass, in comparison with the animals kept on the HFHLD only [ 7 ]. This study demonstrated that resveratrol administered under RCL and HFHLD reduces the MDA-TBA 2 level and its increment over 1.5-h incubation in pro-oxidant ascorbate-iron buffer that points out the LPO restrain and growth in general antioxidant blood potential.…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, additional clinical data are required to support the results so far. Since this study investigated the effects of resveratrol under the combined action of two factors (HFHLD and RCL), which can cause more pronounced inflammatory and metabolic disorders, as shown in our previous paper [ 7 ], the assessment of effects produced by resveratrol under separate action of these factors requires special experimental design, including additional control groups. Moreover, the measurement of serum melatonin in the morning does not reveal the regularities of its circadian rhythmicity in rats during the experiment.…”

Section: Discussionmentioning

confidence: 99%

“…Our more recent studies on rats have proven that the melatonin concentration in the blood serum can considerably decrease under combined exposure to round-the-clock lighting (RCL) and a high-fructose high-lipid diet (HFHLD) for 60 days [ 7 ]. The administration of melatonin under this condition partly lessens the manifestation of carbohydrate and lipid metabolism disorders and signs of nitro-oxidative stress in the skeletal muscles and the liver of rats, though a homeostatic model assessment insulin resistance (HOMA-IR) index under this condition demonstrates no significant changes [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

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Dietary Supplementation with Resveratrol Attenuates Serum Melatonin Level, Pro-Inflammatory Response and Metabolic Disorder in Rats Fed High-Fructose High-Lipid Diet under Round-the-Clock Lighting

Frenkel

Черно

Kostenko³

et al. 2023

Pathophysiology

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This study aims to investigate the effect of resveratrol on systemic inflammatory response and metabolic disorder in rats fed a high-fructose high-lipid diet (HFHLD) and exposed to round-the-clock lighting (RCL). 21 adult male Wistar rats were randomly divided into 3 groups: control (group 1, n = 7); HFHLD for 8 weeks + round-the-clock lighting (RCL) (group 2, n = 7); HFHLD + RCL + Resveratrol (in a daily dose of 5 mg/kg intragastrically (group 3, n = 7). Results show that the combined effect of HFHLD and RCL reduces the serum melatonin (p < 0.001) and accelerates pro-inflammatory activities, oxidative stress, and metabolic disorder. There is a significant increase in the serum tumour necrosis factor-alpha (TNF-α) and C-reactive protein (CRP) (both p < 0.001), blood malondialdehyde—thiobarbituric acid adducts (MDA-TBA2) (p < 0.001), serum glucose (p < 0.01), insulin concentration, and the homeostatic model assessment insulin resistance (HOMA-IR) index (both p < 0.001), serum with very low-density lipoprotein (VLDL), and triacylglycerol (TAG) (both p < 0.001). At the same time, the decrease in the serum high-density lipoprotein (HDL) level (p < 0.001) is observed in the HFHLD + RCL group compared to the control. In the HFHLD + RCL + Resveratrol group, hypomelatonaemia (p < 0.001), pro-inflammatory actions, oxidative stress, and metabolic disorder were mitigated. Resveratrol can cause a significant rise in the serum melatonin and reduce serum TNF-α and CRP levels (both p < 0.001), blood MDA-TBA2 (p < 0.001), serum glucose (both p < 0.01), insulin concentration, and HOMA-IR (both p < 0.001), serum VLDL and TAG (both p < 0.001) compared to the group 2, while serum HDL level increases (p < 0.01). Resveratrol attenuates pro-inflammatory responses and prevents considerable metabolic disorder in rats fed HFHLD under RCL.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Dietary Supplementation with Resveratrol Attenuates Serum Melatonin Level, Pro-Inflammatory Response and Metabolic Disorder in Rats Fed High-Fructose High-Lipid Diet under Round-the-Clock Lighting

Frenkel

Черно

Kostenko³

et al. 2023

Pathophysiology

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“…Розвиток гіпомелатонінемії при цілодобовому освітленні (ЦО) щурів посилюється призначенням щурам висококалорійного вуглеводно-ліпідного раціону [8]. Проте відновлення вмісту мелатоніну при його екзогенному введенні суттєво не впливає на індекс інсулінорезистентності HOMA-IR (Homeostasis Model Assessment of Insulin Resistance) та лише частково обмежує гіпер-глікемію, дисліпопротеїнемію та продукцію активних форм кисню й азоту (АФК і АФА відповідно) в тканинах скелетних м'язів і печінки [9].…”

Section: вступunclassified

Effect of Nf-Κb and Nrf2 Transcription Factor Modulators on Indicators of Oxidative– Nitrosative Stress in Skeletal Muscles of Rats Under Chronic Hypomelatoninemia and Carbohydrate-Lipid Diet

Frenkel¹,

Черно²,

Костенко³

2023

Fiziol Zh

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This article describes the effect of NF-κB inhibitor ammonium pyrrolidine dithiocarbamate and Nrf2 inducer dimethylfumarate on indicators of oxidative-nitrosative stress in skeletal muscles of rats with chronic hypomelatoninemia, induced by roundthe-clock illumination with an intensity of 1500 lux for 30 days, against the background of a carbohydrate-lipid diet (20% fructose solution and appropriate food) for 60 days. The study demonstrated that the administration of ammonium pyrrolidine dithiocarbamate and dimethylfumarate under the experimental conditions impedes the development of hypomelatoninemia, this was accompanied by a two-fold increase in the blood serum melatonin concentration compared to the control group. Moreover, the administration of ammonium pyrrolidine dithiocarbamate and dimethylfumarate significantly reduces the production of superoxide anion radical by electron transport chains of mitochondria (by 47.9 and 51.3%) and sarcoplasmic reticulum (by 48.6 and 52.0%) in the homogenate of femoral muscles, the total activity of NO synthase (by 37.2 and 36.2%) and its inducible isoform (by 41.1 and 40.0%), the concentration of peroxynitrites of alkaline and alkaline earth metals (by 37.2 and 41.0 %), while the activity of constitutive NO-synthases (by 2.9 and 2.8 times) and their conjugation index (by 5.2 and 5.4 times) increases compared to the respective control values. We suggest that modulators of redox-sensitive transcription factors NF-κB and Nrf2 under conditions of chronic hypomelatoninemia and the exposure to the carbohydrate-lipid diet are effective means to restrain the development of oxidative-nitrosative stress in skeletal muscles.

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Effect of Curcumin on Lipid Peroxidation in the Rat Brain Under Conditions of Round-the-Clock Illumination and High-Calorie Carbohydrate-Lipid Diet

Frankel

Zyuzin

Черно

2023

Act. Probl. of the Modern Med.

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The aim of this study is to assess the effect of the polyphenol curcumin on lipid peroxidation (LPO) in the homogenate of the cerebral hemispheres from rats exposed to the round-the-clock lighting (RCL) and kept on high-calorie carbohydrate-lipid diet (HCCLD). The experiments were performed on 21 white male Wistar rats weighing 210-250 g, divided into 3 groups of 7 animals each. Animals of group 1 (control I) were kept on a standard vivarium diet and equal alternation of light and darkness periods. Rats of groups 2 and 3 during the period of RCL in the setting of HCCLD were daily injected 1 ml of 20% aqueous fructose solution intragastrically through a probe ("placebo", control II) and curcumin in a dose of 200 mg/kg, respectively. The level of lipid peroxidation in the cerebral homogenate was assessed by the formation of a colored trimethine complex in the reaction with thiobarbituric acid (TBA). Keeping rats on the RCL and HCCLD was accompanied by a significant increase in the concentration of TBA reactants before and after the incubation in pro-oxidant buffer solution, by 59.0 and 68.8%, respectively. The administration of curcumin under the experimental conditions significantly reduced the concentration of TBA-active products: before its incubation in the pro-oxidant buffer solution – by 24.4%, after the incubation – by 31.0% compared to the corresponding values in the 2nd group. This enables us to conclude that the administration of the polyphenol curcumin under exposing rats to RCL and keeping them on HCCLD significantly limits the LPO development in the cerebral homogenate of the cerebral hemispheres.

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Influence of chronic hypomelatoninemia on carbohydrate and lipid metabolism of rats kept on western diet

Cited by 5 publications

References 13 publications

Dietary Supplementation with Resveratrol Attenuates Serum Melatonin Level, Pro-Inflammatory Response and Metabolic Disorder in Rats Fed High-Fructose High-Lipid Diet under Round-the-Clock Lighting

Dietary Supplementation with Resveratrol Attenuates Serum Melatonin Level, Pro-Inflammatory Response and Metabolic Disorder in Rats Fed High-Fructose High-Lipid Diet under Round-the-Clock Lighting

Effect of Nf-Κb and Nrf2 Transcription Factor Modulators on Indicators of Oxidative– Nitrosative Stress in Skeletal Muscles of Rats Under Chronic Hypomelatoninemia and Carbohydrate-Lipid Diet

Effect of Curcumin on Lipid Peroxidation in the Rat Brain Under Conditions of Round-the-Clock Illumination and High-Calorie Carbohydrate-Lipid Diet

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