Influence of Chronic Kidney Disease on Physical Function and Quality of Life in Patients after Coronary Artery Bypass Grafting

Abstract

Aims: The purposes of this study were (1) to compare body composition, physical function, and quality of life (QOL) between patients after coronary artery bypass grafting (CABG) with and without chronic kidney disease (CKD) and (2) to analyze the factors associated with physical function and QOL domains in these patients. Methods: Thirty male post-CABG patients with CKD and 30 matched controls were recruited. All subjects underwent dual-energy X-ray absorptiometry for body composition evaluation. Physical function tests included the grip strength test, 30-second chair stand test (30CST), and 6-min walk test (6MWT). Physical activity and QOL were assessed using the long form of the International Physical Activity Questionnaire and the World Health Organization Quality of Life Instrument (WHOQOL)-BREF, respectively. Results: Post-CABG patients with CKD exhibited a lower arm lean mass and higher percent leg fat mass than those without CKD (p < 0.05). The patients with CKD also had lower 30CST scores, 6MWT distances, and QOL domain of social relationships scores than those without CKD after adjusting for covariates (p < 0.05). If NYHA class was considered in the model, NYHA class became the most important factor associated with 6MWT distances (β = -0.647, p < 0.001) and the QOL domains of psychological health (β = -0.285, p = 0.027) and environment (β = -0.406, p = 0.001). Conclusion: Post-CABG patients with CKD had worse body composition, physical function, and QOL than those without CKD, and this might be associated with a worse NYHA class.

Test–retest reliability, validation, and “minimal detectable change” scores for frequently reported tests of objective physical function in patients with non-dialysis chronic kidney disease

“…Chronic kidney disease (CKD) is associated with adverse clinical outcome and reduced quality of life (Levey et al, 2005). CKD patients have reduced physical functioning (Hiraki et al, 2013;Kuo et al, 2015;Segura-Ortí, Gordon, Doyle, and Johansen, 2017), which is partly attributable to fatigue and muscle wasting characteristic of the condition (Wang and Mitch, 2014). Reductions in physical function begin early in the disease process (Hiraki et al, 2013), and are independently associated with mortality (Roshanravan et al, 2013).…”

Physical Activity in End-Stage Renal Disease Patients: The Effects of Starting Dialysis in the First 6 Months after the Transition Period

“…This may be of prognostic importance, as lower lean tissue index (LTI; lean tissue mass [LTM] corrected for height) is related to higher mortality, although the relation between fat tissue index (FTI; adipose tissue mass [ATM] corrected for height) and survival in dialysis patients is not straightforward [10] . However, to the best of our knowledge, only limited data are available to assess the association between PA and BC in a cohort including CKD-5 non-dialysis and dialysis patients [11][12][13] .…”

Prior percutaneous coronary intervention is associated with low health‐related quality of life after coronary artery bypass graft

“…Our findings therefore contradict previous studies. Kuo, Chiu, Tsang, Chiu, and Chien (2015) found that patients with chronic kidney disease (CKD) post-CABG surgery had worse physical function and HRQoL than patients not suffering CKD. Shad et al (2017) showed that the physical and mental components of HRQoL were better in patients with no comorbidities (diabetes mellitus or hypertension).…”