Influence of chronic liver disease and chronic renal failure on nutrient metabolism and undernutrition

Cano, Noël; Leverve, Xavier

doi:10.1016/s0899-9007(97)00067-1

Cited by 2 publications

(2 citation statements)

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“…In the present study, aortic banding led to renal and hepatic alterations, which have a major influence on amino acid metabolism. Amino acid levels in renal failure have been reported (9). However, the amino acid pattern reported here are quite different from those associated with pure renal failure, probably because of the multiorgan failure situation, including liver failure.…”

Section: Discussioncontrasting

confidence: 55%

“…Plasma amino acids reflect a balance in amino acid fluxes between muscle and visceral organs (15). Moreover, the degree of hypermetabolism and the fate of specific tissue alterations make the pattern of plasma and muscle amino acids characteristic of each pathological situation (8,9,14,22,43). In the present study, aortic banding led to renal and hepatic alterations, which have a major influence on amino acid metabolism.…”

Section: Discussionmentioning

confidence: 58%

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Aortic banding in rat as a model to investigate malnutrition associated with heart failure

Héliès-Toussaint¹,

Moinard²,

Rasmusen³

et al. 2005

American Journal of Physiology-Regulatory, Integrative and Comp

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Heart failure is a severe pathology, which has displayed a dramatic increase in the occurrence of patients with chronic heart disease in developed countries, as a result of increases in the population's average age and in survival time. This pathology is associated with severe malnutrition, which worsens the prognosis. Although the cachexia associated with chronic heart failure is a well-known complication, there is no reference animal model of malnutrition related to heart failure. This study was designed to evaluate the nutritional status of rats in a model of loss of cardiac function obtained by ascending aortic banding. Cardiac overload led to the development of cardiac hypertrophy, which decompensates to heart failure, with increased brain natriuretic peptide levels. The rats displayed hepatic dysfunction and an associated renal hypotrophy and renal failure, evidenced by the alteration in renal function markers such as citrullinemia, creatininemia, and uremia. Malnutrition has been evidenced by the alteration of protein and amino acid metabolism. A muscular atrophy with decreased protein content and increased amino acid concentrations in both plasma and muscle was observed. These rats with heart failure displayed a multiorgan failure and malnutrition, which reflected the clinical situation of human chronic heart failure.

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Section: Discussioncontrasting

confidence: 55%