Influence of Chronic Opioid Delta Receptor Antagonism on Blood Pressure Development and Tissue Contents of Catecholamines and Endogenous Opioids in Spontaneously Hypertensive Rats

Kraft, Karin; Diehl, Jörg; Stumpe, Klaus O.

doi:10.3109/10641969109045063

Cited by 5 publications

(2 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In our work we did not observe an effect of NTI on BP level; however, another group has demonstrated that in young hypertensive SHR rats, four weeks of antagonism of δ opioid receptors by ICI 154 129 compound (10 µg/h sc.) caused a lowering of BP seen after 3 weeks of treatment (with measurements performed twice a week) [ 55 ]. In these chronically treated rats, an increase in β-endorphins but not enkephalins has been detected in the hypothalamus, which reflects the initiation of compensatory processes, counteracting the persistent inhibition of δ opioid receptors by the reprogramming of opioid peptide synthesis towards the enhanced production of endogenous ligands for unoccupied µ opioid receptors [ 55 ].…”

Section: Discussionmentioning

confidence: 99%

“…caused a lowering of BP seen after 3 weeks of treatment (with measurements performed twice a week) [ 55 ]. In these chronically treated rats, an increase in β-endorphins but not enkephalins has been detected in the hypothalamus, which reflects the initiation of compensatory processes, counteracting the persistent inhibition of δ opioid receptors by the reprogramming of opioid peptide synthesis towards the enhanced production of endogenous ligands for unoccupied µ opioid receptors [ 55 ]. Since µ opioid receptor agonism usually contributes to hypotension, the effect authors observed likely could be assigned to β-endorphin action.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

The Role of Opioid Receptor Antagonists in Regulation of Blood Pressure and T-Cell Activation in Mice Selected for High Analgesia Induced by Swim Stress

Skiba,

Jaskuła,

Nawrocka

et al. 2024

IJMS

View full text Add to dashboard Cite

Opioid peptides and their G protein-coupled receptors are important regulators within the cardiovascular system, implicated in the modulation of both heart and vascular functions. It is known that naloxone—an opioid antagonist—may exert a hypertensive effect. Recent experimental and clinical evidence supports the important role of inflammatory mechanisms in hypertension. Since opioids may play a role in the regulation of both blood pressure and immune response, we studied these two processes in our model. We aimed to evaluate the effect of selective and non-selective opioid receptor antagonists on blood pressure and T-cell activation in a mouse model of high swim stress-induced analgesia. Blood pressure was measured before and during the infusion of opioid receptor antagonists using a non-invasive tail–cuff measurement system. To assess the activation of T-cells, flow cytometry was used. We discovered that the non-selective antagonism of the opioid system by naloxone caused a significant elevation of blood pressure. The selective antagonism of μ and κ but not δ opioid receptors significantly increased systolic blood pressure. Subsequently, a brief characterization of T-cell subsets was performed. We found that the blockade of μ and δ receptors is associated with the increased expression of CD69 on CD4 T-cells. Moreover, we observed an increase in the central memory CD4 and central memory CD8 T-cell populations after the δ opioid receptor blockade. The antagonism of the μ opioid receptor increased the CD8 effector and central memory T-cell populations.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

The Role of Opioid Receptor Antagonists in Regulation of Blood Pressure and T-Cell Activation in Mice Selected for High Analgesia Induced by Swim Stress

Skiba,

Jaskuła,

Nawrocka

et al. 2024

IJMS

View full text Add to dashboard Cite

show abstract

Brain opioid and nociceptin receptors are involved in regulation of bombesin-induced activation of central sympatho-adrenomedullary outflow in the rat

et al. 2015

View full text Add to dashboard Cite

Previously, we reported that central administration of bombesin, a stress-related peptide, elevated plasma levels of catecholamines (noradrenaline and adrenaline) in the rat. The sympatho-adrenomedullary system, which is an important component of stress responses, can be regulated by the central opioid system. In the present study, therefore, we examined the roles of brain opioid receptor subtypes (µ, δ, and κ) and nociceptin receptors, originally identified as opioid-like orphan receptors, in the bombesin-induced activation of central sympatho-adrenomedullary outflow using anesthetized male Wistar rats. Intracerebroventricularly (i.c.v.) administered bombesin-(1 nmol/animal) induced elevation of plasma catecholamines was significantly potentiated by pretreatment with naloxone (300 and 1000 µg/animal, i.c.v.), a non-selective antagonist for µ-, δ-, and κ-opioid receptors. Pretreatment with cyprodime (100 µg/animal, i.c.v.), a selective antagonist for µ-opioid receptors, also potentiated the bombesin-induced responses. In contrast, pretreatment with naltrindole (100 µg/animal, i.c.v.) or nor-binaltorphimine (100 µg/animal, i.c.v.), a selective antagonist for δ- or κ-opioid receptors, significantly reduced the elevation of bombesin-induced catecholamines. In addition, pretreatment with JTC-801 (30 and 100 µg/animal, i.c.v.) or J-113397 (100 µg/animal, i.c.v.), which are selective antagonists for nociceptin receptors, also reduced the bombesin-induced responses. These results suggest that brain µ-opioid receptors play a suppressive role and that brain δ-, κ-opioid, and nociceptin receptors play a facilitative role in the bombesin-induced elevation of plasma catecholamines in the rat. Thus, in the brain, these receptors could play differential roles in regulating the activation of central sympatho-adrenomedullary outflow.

show abstract

Chronic κ-opioid receptor antagonism delays the rise in blood pressure in spontaneously hypertensive rats

Kraft

Diehl

Egen

et al. 1991

European Journal of Pharmacology

View full text Add to dashboard Cite

Influence of Chronic Opioid Delta Receptor Antagonism on Blood Pressure Development and Tissue Contents of Catecholamines and Endogenous Opioids in Spontaneously Hypertensive Rats

Cited by 5 publications

References 20 publications

The Role of Opioid Receptor Antagonists in Regulation of Blood Pressure and T-Cell Activation in Mice Selected for High Analgesia Induced by Swim Stress

The Role of Opioid Receptor Antagonists in Regulation of Blood Pressure and T-Cell Activation in Mice Selected for High Analgesia Induced by Swim Stress

Brain opioid and nociceptin receptors are involved in regulation of bombesin-induced activation of central sympatho-adrenomedullary outflow in the rat

Chronic κ-opioid receptor antagonism delays the rise in blood pressure in spontaneously hypertensive rats

Contact Info

Product

Resources

About