Influence of Chronic Social Defeat Stress on Digestive System Functioning in Rats

Toyoda, Atsushi; Iio, Wataru; Matsukawa, Noriko; Tsukahara, Takamitsu

doi:10.3177/jnsv.61.280

Cited by 5 publications

(3 citation statements)

References 20 publications

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“…This reduction in the weight of the milking and caecum could be in line with previous studies in which CR and FS stress have shown to reduce body weight and food intake. 21,47 Additionally, other factors such as an increase in nutrient absorption 48 and augmented metabolic efficiency due to cold temperature, 49 could possibly also contribute to the decrease in weight gain and reduced milking.…”

Section: Discussionmentioning

confidence: 99%

Effects of two different acute and subchronic stressors on gastrointestinal transit in the rat: A radiographic analysis

Bagüés

López-Tofiño

Gálvez-Robleño

et al. 2021

Neurogastroenterology Motil

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Background:The reaction to stress is an adaptive response necessary for survival.When stressors are repeated, the organism adapts, although these adaptive responses can become dysregulated and result in disease, causing gastrointestinal (GI) disorders.Radiographic methods allow the non-invasive study of how a given factor affects GI transit in the same animal at different time points. These methods have never been applied to study the consequences of stress on GI motor function and their dependency on time and stimulus. Therefore, our aim was to characterize, using radiographic techniques, the effect on GI transit of cold-restraint (CR) and forced swim (FS) stress applied acutely and subchronically in the rat.Methods: Male Wistar rats (260-330 g) were submitted to FS or CR stress, during 1 (acute) or 4 (subchronic) consecutive days. To study GI transit, radiographic methods were used. Radiographs were taken 0-24 h after barium intragastric administration on the 1st or 4th day of stress, which was applied 1 h after contrast.Results: Acute FS or CR slowed down gastric and small intestinal emptying but had opposite effects in the caecum: CR tended to accelerate barium transit and feces formation while FS tended to slow these parameters down. When the stimuli were applied subchronically, GI transit was not completely normalized in most of the studied parameters. Conclusion and Inferences:Mild stress alters GI transit differently depending on the nature of the stressor and its duration. Exposure to mild stressors should be considered as contributing factors to different functional GI disorders.

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Section: Discussionmentioning

confidence: 99%

Effects of two different acute and subchronic stressors on gastrointestinal transit in the rat: A radiographic analysis

Bagüés

López-Tofiño

Gálvez-Robleño

et al. 2021

Neurogastroenterology Motil

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“…Rodents subjected to chronic social defeat stress , are used as animal models of depression due to their higher construct, face, and predictive validities compared with other models of depression. , Toyoda and his colleagues − studied several aspects of nutrition and metabolism in chronically socially defeated rats, including appetite regulation and nutrient absorption in the digestive tract, to understand psychological stress-induced disorders and find some clinically useful insights.…”

Section: Introductionmentioning

confidence: 99%

Effects of Diet Quality and Psychosocial Stress on the Metabolic Profiles of Mice

2017

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There has been an increasing interest in relationship between stress and diet. To address this relationship, we evaluated an animal model of depression: male C57BL/6J mice subjected to subchronic mild social defeat stress (sCSDS) for 10 consecutive days using male ICR mice under two different calorie-adjusted diets conditions-nonpurified (MF) and semipurified (AIN) diets made from natural and chemical ingredients mainly, respectively. Our previous study indicates that diet quality and purity affect stress susceptibility in sCSDS mice. We therefore hypothesized that there are some key peripheral metabolites to change stress-susceptible behavior. GC-MS metabolomics of plasma, liver, and cecal content were performed on four test groups: sCSDS + AIN diet (n = 7), sCSDS + MF diet (n = 6), control (no sCSDS) + AIN diet (n = 8), and control + MF diet (n = 8). Metabolome analyses revealed that the number of metabolites changed by food was larger than the number changed by stress in all tissues. Enrichment analysis of the liver metabolite set altered by food implies that stress-susceptible mice show increased glycolysis-related substrates in the liver. We found metabolites that were affected by stress (e.g., plasma and liver 4-hydroxyproline and plasma beta-alanine are higher in sCSDS than in control) and a stress × food interaction (e.g., plasma GABA is lower in sCSDS + AIN than in sCSDS + MF). Because functional compounds were altered by both stress and food, diet may be able to attenuate various stress-induced symptoms by changing metabolites in peripheral tissues.

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“…CSDS models establish social stress using male territorial aggression (Kudryavtseva et al, 1991 ; Miczek et al, 2008 ; Hammels et al, 2015 ). We previously studied CSDS rats and found that social stress induces alterations in the MAP kinase cascade, hypothalamic malonyl-CoA, peripheral leptin, digestive system, and behaviors (Iio et al, 2011 , 2012b , 2014 ; Toyoda et al, 2015 ). Others have analyzed both central nervous system and peripheral tissues in relation to stress resilience using CSDS mice (Russo and Nestler, 2013 ; Hodes et al, 2014 ; Pfau and Russo, 2015 ).…”

Section: Introductionmentioning

confidence: 99%

Murine Depression Model and its Potential Applications for Discovering Foods and Farm Products with Antidepressant-Like Effects

et al. 2016

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Advanced societies face increased health problems related to various stresses. Chronic psychological stress is a major risk factor for psychiatric disorders such as depression. Although therapeutic agents reduce several symptoms of depression, most have side effects in a broad range of the population. Furthermore, some victims of depression do not show significant improvement with any drugs, so alternative approaches are needed. Good dietary habits may potentially reduce depressive symptoms, but there is little scientific evidence thus far. Murine depression models are useful to test nutritional approaches in vivo. Our model mice subjected to a subchronic mild social defeat stress (sCSDS) paradigm show several alterations in physiological parameters and social behavior. These stress-induced symptoms in sCSDS mice can be used as cues to identify antidepressant-like natural resources including foods and farm products. We previously discovered that sCSDS mice show more vulnerability to social stress by changing dietary condition. In addition, we developed a more objective system for analyzing mouse behavior using a 3D depth-sensing camera to understand relationships between diet and behavior. The combination of sCSDS mice with 3D behavioral analysis is a powerful method for screening ingredients in foods and farm products for antidepressant-like effects.

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Influence of Chronic Social Defeat Stress on Digestive System Functioning in Rats

Cited by 5 publications

References 20 publications

Effects of two different acute and subchronic stressors on gastrointestinal transit in the rat: A radiographic analysis

Effects of two different acute and subchronic stressors on gastrointestinal transit in the rat: A radiographic analysis

Effects of Diet Quality and Psychosocial Stress on the Metabolic Profiles of Mice

Murine Depression Model and its Potential Applications for Discovering Foods and Farm Products with Antidepressant-Like Effects

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