Influence of chronotype on the incidence and severity of perinatal depression in the “Life-ON” study

Garbazza, Corrado; Hackethal, Sandra; Migliore, Enrica; D’Agostino, Armando; C, Serrati; Fanti, Valentina; Riccardi, Silvia; Baiardi, Simone; Cicolin, Alessandro; Borgwardt, Stefan; Mondini, Susanna; Cirignotta, Fabio; Cajochen, Christian; Manconi, Mauro

doi:10.1016/j.jad.2022.08.064

Cited by 8 publications

(2 citation statements)

References 38 publications

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“…Although no direct connection between depression and Neanderthal gene introgression was found in an extensive genome-wide population study (Dannemann et al, 2022), the same investigation identified significant relationships with behavioural phenotypes, including pain, chronotype/ sleep, smoking, and alcohol consumption. The relationship between major depression epidemiology and behavioural phenotypes was repeatedly observed, including the sleep chronotype (Garbazza et al, 2022), smoking (Fluharty et al, 2017), alcohol consumption (Schick et al, 2022), andpain (IsHak et al, 2018). Thus the link between Neanderthal gene introgression and depression may be indirect, taking place via mediators that are not yet known.…”

Section: Discussionmentioning

confidence: 99%

Is Neanderthal gene introgression into Homo sapiens genome an adaptive anti-inflammatory phenomenon that increases depression risk?

Nowak¹,

Pawełczyk²

2023

Psychiatr Psychol Klin

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Genes of Neanderthal ancestry are believed to have become incorporated in the modern Homo sapiens genome via hybridisation and introgression. Although the majority have been eliminated from the population by natural selection due to Dobzhansky–Muller incompatibilities, some of them nevertheless remain, suggesting they have been selected for and have some adaptive value. The current work examines hypotheses explaining the emergence of depressive symptoms and disorders from an evolutionary standpoint. Neither the incentive hypothesis nor any social hypothesis (social position hypothesis, attachment hypothesis, social navigation hypothesis) accommodates any evidence of archaic introgression. However, the immunological hypothesis, corroborated by a considerable body of research, treats depressive symptoms as part of immunologic response. According to the hypothesis, infections have placed a considerable selective pressure on humans. Upon arrival in Eurasia from Africa, Homo sapiens was confronted with unknown pathogenic microorganisms. In contrast, the Neanderthals populating Eurasia had already been adapting to them for millennia. Introgression of Neanderthal man alleles of genes associated with the immunological response has already been demonstrated in Homo sapiens, and may well increase the fitness of newcomers. Such inclusion of genes connected with depressive symptoms may explain why archaic alleles are still present in the gene pool of modern humans.

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Section: Discussionmentioning

confidence: 99%

Is Neanderthal gene introgression into Homo sapiens genome an adaptive anti-inflammatory phenomenon that increases depression risk?

Nowak¹,

Pawełczyk²

2023

Psychiatr Psychol Klin

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“…Pregnant women with evening chronotypes exhibit unhealthy lifestyle habits and sociodemographic characteristics commonly associated with a higher risk for PPD. They also have an increased likelihood of developing PPD symptoms in the first month after delivery [18]. In a study involving 98 healthy mothers at 1 month postpartum, salivary melatonin concentrations taken 30 minutes after awakening were found to be a potentially useful circadian phase marker for identifying the awakening time and detecting circadian rhythm shifts in postpartum mothers.…”

Section: Sleep Disturbance In Postpartum Periodmentioning

confidence: 99%

Exploring the Relationship Between Circadian Rhythm Shifts and Postpartum Depression

Yeom¹,

Lee²

2023

Chronobiol Med

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This review paper explores the relationship between circadian rhythm and postpartum depression (PPD). Postpartum depression is a prevalent and debilitating mood disorder that affects a significant number of women after childbirth. Emerging evidence suggests that disruptions in circadian rhythm may contribute to the development of PPD. This paper provides an overview of the current understanding of circadian rhythm disturbances in the postpartum period, their potential impact on PPD, and the underlying mechanisms involved. Additionally, therapeutic approaches targeting circadian disruptions in the prevention and treatment of PPD are discussed. Further research in this field has the potential to provide novel insights and interventions for the management of PPD.

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Sleep and its association with depressive and anxiety symptoms during the last weeks of pregnancy: A population-based study

Loret de Mola,

Carpena,

Dias

et al. 2023

Sleep Health

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Influence of chronotype on the incidence and severity of perinatal depression in the “Life-ON” study

Cited by 8 publications

References 38 publications

Is Neanderthal gene introgression into Homo sapiens genome an adaptive anti-inflammatory phenomenon that increases depression risk?

Is Neanderthal gene introgression into Homo sapiens genome an adaptive anti-inflammatory phenomenon that increases depression risk?

Exploring the Relationship Between Circadian Rhythm Shifts and Postpartum Depression

Sleep and its association with depressive and anxiety symptoms during the last weeks of pregnancy: A population-based study

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