Influence of citalopram, a selective serotonin reuptake inhibitor, on colonic tone and sensitivity in man

Tack, Jan; Vos, Rita; Broekaert, Dorien; Fischler, Benjamin; Janssens, Jozef

doi:10.1016/s0016-5085(00)82776-6

Cited by 17 publications

(13 citation statements)

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“…Our finding that an SSRI had no effect on visceral sensitivity in healthy humans is consistent with the results of a preliminary report of the SSRI citalopram on colonic sensitivity 19 . In healthy humans, citalopram induced colonic relaxation, and thus an increase in the volume threshold for discomfort, but no change in the pressure threshold for discomfort.…”

Section: Discussionsupporting

confidence: 91%

Effect of the selective serotonin reuptake inhibitor sertraline on gastric sensitivity and compliance in healthy humans¹

Ladabaum¹,

Glidden

2002

Neurogastroenterology Motil

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Visceral hypersensitivity may contribute to symptoms in functional dyspepsia. Selective serotonin reuptake inhibitors (SSRIs) may be beneficial in functional gastrointestinal disorders. The aim of this study was to determine whether the SSRI sertraline affects gastric sensitivity and compliance in healthy humans. Ten healthy humans completed a 6-week randomized, double-blind, crossover trial of sertraline (50 mg day(-1)) vs. placebo. After each 2-week treatment, fullness, pain and nausea were rated at increasing gastric barostat distending pressures. Sensation thresholds above minimal distending pressure (MDP) were determined with a tracking method. Somatic sensory testing was performed by hand immersion in ice water. No differences were found between sertraline and placebo for symptoms as a function of distending pressure (fullness, P = 0.72; pain, P = 0.79; nausea, P = 0.41), gastric compliance (P = 0.15), median and interquartile range thresholds for first sensation [4.1 (3.5-5.7) vs. 6.2 (3.3-10.0) mmHg above MDP, P = 0.19] and pain [15.2 (8.3-21.0) vs. 15.3 (10.3-19.8) mmHg above MDP, P = 0.85], and median tolerance times for hand ice water immersion [27 (19-99) vs. 29 (20-180) s, P = 0.73]. In conclusion, sertraline had no effect on gastric sensitivity or compliance, or somatic pain tolerance in healthy humans. Studies are needed to assess the effects of SSRIs on visceral sensation and clinical symptoms in patients with functional dyspepsia.

show abstract

Section: Discussionsupporting

confidence: 91%

Effect of the selective serotonin reuptake inhibitor sertraline on gastric sensitivity and compliance in healthy humans¹

Ladabaum¹,

Glidden

2002

Neurogastroenterology Motil

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“…53 The activity of citalopram has to be evaluated further to determine whether inhibition of the colonic motor response to feeding noted with this drug results from the effects on 5-HT reuptake as an SSRI or from other actions.…”

Section: Other Research Approaches Involving 5-ht Agentsmentioning

confidence: 99%

Serotonergic modulation of visceral sensation: lower gut

Camilleri

2002

Gut

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“…However, limited data exist on the effects of SSRIs on visceral sensation or on clinical symptoms in the functional gastrointestinal disorders. [18][19][20][21] The precise mechanism of action of SSRIs in the treatment of depression is not fully understood, but chronic administration of these agents has been reported to downregulate the serotonin transmitter responsible for serotonin reuptake, 22 as well as serotonergic receptors. 23,24 We wished to test the hypothesis that visceral sensitivity can be affected by treatment with SSRIs.…”

Section: Introductionmentioning

confidence: 99%

The selective serotonin reuptake inhibitor sertraline does not affect gastric sensitivity or compliance in healthy humans

LADABAUM¹,

GLIDDEN²

2001

Gastroenterology

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Visceral hypersensitivity may contribute to symptoms in functional dyspepsia. Selective serotonin reuptake inhibitors (SSRIs) may be beneficial in functional gastrointestinal disorders. The aim of this study was to determine whether the SSRI sertraline affects gastric sensitivity and compliance in healthy humans. Ten healthy humans completed a 6-week randomized, double-blind, crossover trial of sertraline (50 mg day )1 ) vs. placebo. After each 2-week treatment, fullness, pain and nausea were rated at increasing gastric barostat distending pressures. Sensation thresholds above minimal distending pressure (MDP) were determined with a tracking method. Somatic sensory testing was performed by hand immersion in ice water. No differences were found between sertraline and placebo for symptoms as a function of distending pressure (fullness, P ¼ 0.72; pain, P ¼ 0.79; nausea, P ¼ 0.41), gastric compliance (P ¼ 0.15), median and interquartile range thresholds for first sensation [4.1 (3.5-5.7) vs. 6.2 (3.3-10.0) mmHg above MDP, P ¼ 0.19] and pain [15.2 (8.3-21.0) vs. 15.3 (10.3-19.8) mmHg above MDP, P ¼ 0.85], and median tolerance times for hand ice water immersion [27 (19-99) vs. 29 (20-180) s, P ¼ 0.73]. In conclusion, sertraline had no effect on gastric sensitivity or compliance, or somatic pain tolerance in healthy humans. Studies are needed to assess the effects of SSRIs on visceral sensation and clinical symptoms in patients with functional dyspepsia.

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Influence of citalopram, a selective serotonin reuptake inhibitor, on colonic tone and sensitivity in man

Cited by 17 publications

References 0 publications

Effect of the selective serotonin reuptake inhibitor sertraline on gastric sensitivity and compliance in healthy humans¹

Effect of the selective serotonin reuptake inhibitor sertraline on gastric sensitivity and compliance in healthy humans¹

Serotonergic modulation of visceral sensation: lower gut

The selective serotonin reuptake inhibitor sertraline does not affect gastric sensitivity or compliance in healthy humans

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Influence of citalopram, a selective serotonin reuptake inhibitor, on colonic tone and sensitivity in man

Cited by 17 publications

References 0 publications

Effect of the selective serotonin reuptake inhibitor sertraline on gastric sensitivity and compliance in healthy humans1

Effect of the selective serotonin reuptake inhibitor sertraline on gastric sensitivity and compliance in healthy humans1

Serotonergic modulation of visceral sensation: lower gut

The selective serotonin reuptake inhibitor sertraline does not affect gastric sensitivity or compliance in healthy humans

Contact Info

Product

Resources

About

Effect of the selective serotonin reuptake inhibitor sertraline on gastric sensitivity and compliance in healthy humans¹

Effect of the selective serotonin reuptake inhibitor sertraline on gastric sensitivity and compliance in healthy humans¹