Influence of Clonidine on Antihypertensive Selective Afferent Vagal Nerve Stimulation in Rats

Gierthmuehlen, Mortimer; Aguirre, Debora; Cota, Oscar; Zentner, Josef; Plachta, Dennis T. T.

doi:10.1111/ner.12463

Cited by 3 publications

(1 citation statement)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In preclinical studies, it has been shown that the BP in rats could be reduced up to 40% of the baselines without causing significant bradycardia [63]. Interference with commonly used antihypertensive medication seemed to be minimal [64][65][66]. This method of activating the baroreflex also seems to keep the BP low even without constant stimulation, but synchronized to the electrocardiogram (ECG) [20•].…”

Section: Vagal Nerve Stimulationmentioning

confidence: 99%

Implant-Mediated Therapy of Arterial Hypertension

2020

Self Cite

View full text Add to dashboard Cite

Purpose of Review To give an overview on recent developments in permanent implant-based therapy of resistant hypertension. Recent Findings The American Heart Association (AHA) recently updated their guidelines to treat high blood pressure (BP). As elevated BP now is defined as a systolic BP above 120 mmHg, the prevalence of hypertension in the USA has increased from 32% (old definition of hypertension) to 46%. In the past years, device-and implant-mediated therapies have evolved and extensively studied in various patient populations. Despite an initial drawback in a randomized controlled trial (RCT) of bilateral carotid sinus stimulation (CSS), new and less invasive and unilateral systems for baroreflex activation therapy (BAT) with the BAROSTIM NEO® have been developed which show promising results in small non-randomized controlled (RCT) studies. Selective vagal nerve stimulation (VNS) has been successfully evaluated in rodents, but has not yet been tested in humans. A new endovascular approach to reshape the carotid sinus to lower BP (MobiusHD™) has been introduced (baroreflex amplification therapy) with favorable results in non-RCT trials. However, long-term results are not yet available for this treatment option. A specific subgroup of patients, those with indication for a 2-chamber cardiac pacemaker, may benefit from a new stimulation paradigm which reduces the AV latency and therefore limits the filling time of the left ventricle. The most invasive approach for resistant hypertension still is the neuromodulation by deep brain stimulation (DBS), which has been shown to significantly lower BP in single cases. Summary Implant-mediated therapy remains a promising approach for the treatment of resistant hypertension. Due to their invasiveness, such treatment options must prove superiority over conventional therapies with regard to safety and efficacy before they can be generally offered to a wider patient population. Overall, BAROSTIM NEO® and MobiusHD™, for which large RCTs will soon be available, are likely to meet those criteria and may represent the first implant-mediated therapeutical options for hypertension, while the use of DBS probably will be reserved for individual cases. The utility of VNS awaits appropriate assessment.

show abstract

Section: Vagal Nerve Stimulationmentioning

confidence: 99%

Implant-Mediated Therapy of Arterial Hypertension

2020

Self Cite

View full text Add to dashboard Cite

show abstract

Wenn Technik den Nerv trifft – Strom für elektronische Pillen und fühlende Prothesen

Stieglitz

2020

Bessere Menschen? Technische Und Ethische Fragen in Der Transhumanistischen Zukunft

View full text Add to dashboard Cite

Vagus Nerve Stimulation and the Cardiovascular System

Capilupi

Kerath

Becker

2019

Cold Spring Harb Perspect Med

129

View full text Add to dashboard Cite

The vagus nerve plays an important role in maintaining physiological homeostasis, which includes reflex pathways that regulate cardiac function. The link between vagus nerve activity and the high-frequency component of heart rate variability (HRV) has been well established, correlating with vagal tone. Recently, vagus nerve stimulation (VNS) has been investigated as a therapeutic for a multitude of diseases, such as treatment-resistant epilepsy, rheumatoid arthritis, Crohn's disease, and asthma. Because of the vagus nerve's innervation of the heart, VNS has been identified as a potential therapy for cardiovascular disorders, such as cardiac arrest, acute myocardial infarction, and stroke. Here, we review the current state of preclinical and clinical studies, as well as the potential application of VNS in relation to the cardiovascular system.

show abstract

Influence of Clonidine on Antihypertensive Selective Afferent Vagal Nerve Stimulation in Rats

Cited by 3 publications

References 43 publications

Implant-Mediated Therapy of Arterial Hypertension

Implant-Mediated Therapy of Arterial Hypertension

Wenn Technik den Nerv trifft – Strom für elektronische Pillen und fühlende Prothesen

Vagus Nerve Stimulation and the Cardiovascular System

Contact Info

Product

Resources

About