Monsoon low-pressure systems (LPS) are the major contributor to these heavy rainfall events and pose a significant challenge to operational forecasting agencies in terms of prediction accuracy with adequate lead time, particularly at a district scale. The present study investigates the role of microphysical parameterizations associated with these LPS during the intensification phases, that is, depressions (MD) and deep depressions (DD), using the Weather Research and Forecasting (WRF) model. A total of 130 simulations are carried out (12 MD and 14 DD) using five cloud microphysical parameterizations, that is, WSM6, WDM6, Thompson, Milbrandt, and Aerosol Aware Thompson, up to 96 hr. The study aims to interlink rainfall vulnerability and LPS intensity both at the district scale for the state of Odisha (India). Results suggest that Mayurbhanj is the most vulnerable district in terms of rainfall. The WDM6 has the best skills in terms of rainfall. The analysis of storm energetics is carried out to provide a possible clue about the mechanism facilitating the intensification of specific LPS to DD. Results suggest that DDs are more thermodynamically efficient than MDs to convert the latent energy to kinetic energy, facilitating its intensification process through higher kinetic energy generation and moisture consumption.Further, it is found that deep vertical updraft with the strong inward flow in the lower troposphere supported by intense tangential wind within the 300 km radial periphery is distinct in DD compared to MD. The findings of the study will have direct implications on localized forecast, policy planning, disaster preparedness, mitigation, and adaptation.