Influence of co-evolution with a parasite, Nosema whitei, and population size on recombination rates and fitness in the red flour beetle, Tribolium castaneum

Greeff, Michael; Schmid‐Hempel, Paul

doi:10.1007/s10709-010-9454-z

Cited by 9 publications

(14 citation statements)

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“…It appears that recombination frequency in populations of T. castaneum responds very quickly to selection [39], which suggests that our result is due to actual, adaptive evolutionary change. Indeed, no evidence was found for an infection-induced plastic change in recombination in this system [30]. …”

Section: Resultsmentioning

confidence: 99%

“…Besides double recombination events, also crossover interference could affect the observed recombination frequency. As crossover interference has been shown to occur in T. castaneum [30], we decided to use Kosambi's map function [47] to calculate map distances from our observed recombination frequencies. Kosambi's function corrects for both double recombination events and the occurrence of crossover interference [46].…”

Section: Methodsmentioning

confidence: 99%

“…Direct experimental support for a change in recombination rate compatible with the Red Queen Hypothesis in obligatory outcrossing species has so far only been reported in one of our earlier studies using Tribolium castaneum as the host and Nosema whitei as its parasite [29]. This finding could not be confirmed in a follow-up study [30], yet post-hoc checks suggested that the extant genetic variation in the hosts probably was too small to sustain an adaptive response (unpubl. data).…”

Section: Introductionmentioning

confidence: 96%

“…More specifically, recombination frequencies were measured in males from both treatments after eleven discrete generations, using microsatellite markers that bordered ten intervals on the genome, which were distributed over four linkage groups. Using this method enabled us to measure recombination directly in the individuals under selection, as opposed to earlier studies that measured recombination in the offspring of the selected individuals, and provided us with a better genomic coverage than in any previous study [29,30]. The experimental design was such that control (no parasite) and coevolution (with parasites) treatments were paired within each of the eight replicate lines of the host.…”

Section: Introductionmentioning

confidence: 99%

“…We chose the conditions of the experiment (number of generations, replicate lines, etc.) based on the experience and results gained in previous experiments with the same study system [29,30]. …”

Section: Introductionmentioning

confidence: 99%

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Antagonistic experimental coevolution with a parasite increases host recombination frequency

et al. 2012

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BackgroundOne of the big remaining challenges in evolutionary biology is to understand the evolution and maintenance of meiotic recombination. As recombination breaks down successful genotypes, it should be selected for only under very limited conditions. Yet, recombination is very common and phylogenetically widespread. The Red Queen Hypothesis is one of the most prominent hypotheses for the adaptive value of recombination and sexual reproduction. The Red Queen Hypothesis predicts an advantage of recombination for hosts that are coevolving with their parasites. We tested predictions of the hypothesis with experimental coevolution using the red flour beetle, Tribolium castaneum, and its microsporidian parasite, Nosema whitei.ResultsBy measuring recombination directly in the individuals under selection, we found that recombination in the host population was increased after 11 generations of coevolution. Detailed insights into genotypic and phenotypic changes occurring during the coevolution experiment furthermore helped us to reconstruct the coevolutionary dynamics that were associated with this increase in recombination frequency. As coevolved lines maintained higher genetic diversity than control lines, and because there was no evidence for heterozygote advantage or for a plastic response of recombination to infection, the observed increase in recombination most likely represented an adaptive host response under Red Queen dynamics.ConclusionsThis study provides direct, experimental evidence for an increase in recombination frequency under host-parasite coevolution in an obligatory outcrossing species. Combined with earlier results, the Red Queen process is the most likely explanation for this observation.

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Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Antagonistic experimental coevolution with a parasite increases host recombination frequency

et al. 2012

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Experimental coevolution of species interactions

Brockhurst¹,

Koskella²

2013

Trends in Ecology & Evolution

197

172

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6Coevolution, the process of reciprocal adaptation and counter-adaptation between 7 ecologically interacting species, affects almost all organisms and is considered a key 8 force structuring biological diversity. Our understanding of the pattern and process 9 of coevolution, particularly of antagonistic species interactions, has been hugely 10 advanced in recent years by an upsurge in experimental studies that directly observe 11 coevolution in the laboratory. These experiments pose new questions by revealing 12 novel facets of the coevolutionary process not captured by current theory while also 13 providing the first empirical tests of longstanding coevolutionary ideas, including the 14 influential Red Queen hypothesis. We highlight emerging directions for this field, 15 including experimental coevolution of mutualistic interactions and understanding 16 how pairwise coevolutionary processes scale-up within species-rich communities. 17 18Keywords: experimental evolution; coevolution; species interactions; host-parasite; mutualism 19 Ecology and Evolution 28:367-375 doi: 10.1016/j.tree.2013.02 Published in Trends in The rise of experimental coevolution 23Naturalists have long recognised the importance of species interactions as a driving force of 24 adaptation. Indeed, 19 th -century evolutionary biologists often cited the conspicuous 25 coadaptations of interspecific pollination and mimicry mutualisms as exemplars of 26 evolution by natural selection. It is perhaps surprising then that coevolution, the process of 27 reciprocal adaptation and counter adaptation by ecologically interacting species, was not 28 studied in earnest until the mid-20 th century. The first wave of empirical coevolution research 29 was predominantly observational and field-based [1, 2]. Such studies inferred the action of 30 reciprocal selection indirectly, typically from spatial patterns of trait co-variation between 31 populations or by comparative and phylogenetic analyses of ecologically interacting clades. 32These early studies strongly suggested that coevolution was a central process driving natural 33 selection and shaping the structure and function of communities, while never being able to 34 provide unequivocal evidence of reciprocal evolutionary changes. 35 36To overcome certain limitations of fieldwork -chiefly that the action of other sources of 37 selection driving the observed patterns can never be ruled out -researchers have sought to 38 bring the study of coevolution into the lab. Here, environments can be precisely controlled 39 to exclude extraneous sources of selection, and the use of fast-growing organisms like 40 microbes or classic lab-model animals, allows for the direct observation of coevolution in 41 real time (Figure 1 & Box 1). Significantly, since many such experimental systems are 42 amenable to cryogenic preservation, this allows experimenters to perform Òtime-shifts,Ó for 43 instance, testing the performance of parasites against hosts from the evolutionary past or 44 future (Figure 2). By analyzing these...

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Host–parasite coevolution: why changing population size matters

Papkou

Gokhale

Traulsen

et al. 2016

Zoology

105

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Host-parasite coevolution is widely assumed to have a major influence on biological evolution, especially as these interactions impose high selective pressure on the reciprocally interacting antagonists. The exact nature of the underlying dynamics is yet under debate and may be determined by recurrent selective sweeps (i.e., arms race dynamics), negative frequency-dependent selection (i.e., Red Queen dynamics), or a combination thereof. These interactions are often associated with reciprocally induced changes in population size, which, in turn, should have a strong impact on co-adaptation processes, yet are neglected in most current work on the topic. Here, we discuss potential consequences of temporal variations in population size on host-parasite coevolution. The limited empirical data available and the current theoretical literature in this field highlight that the consideration of such interaction-dependent population size changes is likely key for the full understanding of the coevolutionary dynamics, and, thus, a more realistic view on the complex nature of species interactions.

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Influence of co-evolution with a parasite, Nosema whitei, and population size on recombination rates and fitness in the red flour beetle, Tribolium castaneum

Cited by 9 publications

References 31 publications

Antagonistic experimental coevolution with a parasite increases host recombination frequency

Antagonistic experimental coevolution with a parasite increases host recombination frequency

Experimental coevolution of species interactions

Host–parasite coevolution: why changing population size matters

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