Influence of co-morbidity on long-term quality of life after oesophagectomy for cancer

Djärv, Therese; Derogar, Maryam; Lagergren, Pernilla

doi:10.1002/bjs.9417

Cited by 27 publications

(33 citation statements)

References 24 publications

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“…It is likely that most patients recover quality of life while a significant number of patients who survive 5 years after oesophagectomy with cancer still experience decreased HRQL [6]. Failure to recover reduced HRQL after oesophagectomy has been found to be associated with the occurrence of major postoperative complications and the presence of co-morbidity [14,15]. In our study, the occurrence of complications or the presence of co-morbidity was not Table 3 Spearman's rank correlation coefficients between quality of life scores and follow-up more than 1 year after oesophagectomy.…”

Section: Discussionmentioning

confidence: 98%

Long-term quality of life after oesophagectomy with gastric conduit interposition for cancer

Akkerman

Haverkamp

Rossum

et al. 2015

European Journal of Cancer

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Section: Discussionmentioning

confidence: 98%

Long-term quality of life after oesophagectomy with gastric conduit interposition for cancer

Akkerman

Haverkamp

Rossum

et al. 2015

European Journal of Cancer

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“…Djärv et al used data derived from the previously discussed study (30) to study the relationship between baseline comorbidities of esophageal cancer patients and postoperative HRQOL (32). Several comorbidities were examined: cardiovascular [congestive heart failure (CHF) and angina], pulmonary conditions [asthma and chronic obstructive pulmonary disease (COPD)], diabetes along with liver disease, kidney disease, and elevated hypertension).…”

Section: Postoperative Hrqolmentioning

confidence: 99%

“…Cardiovascular comorbidities were the most common comorbidities, followed by diabetes and pulmonary comorbidities. After esophagectomy, those with comorbidities had a statisticallyand clinically-significant worse global HRQOL at 6 months, 3 and 5 years as well as reports of significantly worse dyspnea and fatigue when compared to those without comorbidities (32). It was unclear whether there was a dose-response relationship such that increasing number of comorbidities was associated with decreasing HRQOL.…”

Section: Postoperative Hrqolmentioning

confidence: 99%

Quality of life assessment in esophagectomy patients

et al. 2018

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Esophagectomy is the mainstay of curative therapy for esophageal cancer; however, it is associated with significant morbidity and mortality, with subsequent major impact on quality of life. This paper reviews the evaluation of health-related quality of life (HRQOL) in esophageal cancer patients undergoing curative intent therapy, the relationship between postoperative HRQOL and survival as well the potential utility of pre-treatment HRQOL as a prognostic tool. HRQOL assessment is valuable in helping clinicians understand the impact on patients of esophageal cancer and the various treatments thereof.HRQOL is also valuable as an end-point in studies of esophageal cancer and esophageal cancer treatment.Given the morbidity and mortality associated with the various treatments for esophageal cancer, it could be argued that HRQOL is as important an endpoint as survival, if not more so. Patient-reported pre-treatment HRQOL assessment appears to predict survival better than clinician-derived performance status assessment period. HRQOL assessment also appears to be responsive to surgical and non-surgical therapy and thus could potentially be used in trials and in practice to serve that function. Thus, HRQOL assessment could be a potentially important adjunct in shared decision-making and guiding treatment planning as well as monitoring the progress of treatment.

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“…17 This is confounded by the presence of comorbidities, 18 postoperative complications, 19 tumor staging, and histological type. 17 This is confounded by the presence of comorbidities, 18 postoperative complications, 19 tumor staging, and histological type.…”

Section: Health-related Quality Of Lifementioning

confidence: 99%

Toward improved survivorship: supportive care needs of esophageal cancer patients, a literature review

Graham

Wikman

2015

Dis Esophagus

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The growing prevalence of esophageal cancer survivors represent a population typified by an extensive treatment regime, significant postsurgical long-term effects, and a dismal prognosis. Despite this, little is known of the supportive care needs of this patient group and the extent to which these are being met in practice. This review provides a synthesis of the research evidence to date; emphasizing opportunities for clinical application and setting a future agenda with research priorities. A literature search was performed using Medline/Embase, PsycINFO, and Web of Science. Search headings used included; [esophagus] or [esopohageal] or [upper gastrointestinal] or [upper GI] AND [cancer] or [carcinoma] or [squamous cell] AND [supportive care] or [survivorship] or [psychological] or [emotional] or [information] or [social] or [communication] or [spiritual] or [health-related-quality-of-life] or [HRQL] or [qualitative] or [patient narrative] or [clinical nurse specialist] or [CNS]. Related articles in English were reviewed, with additional articles harvested from reference sections. Esophageal cancer survivors report significant late-term effects posttreatment, encompassing sustained impairment in most areas of health-related quality of life. With a necessitated change in eating behavior, survivors find it particularly challenging to adjust to a new social identity and as a cancer population report high levels of psychological morbidity. Although the determinants of psychological morbidity are largely unknown, illness representations may be a key contributor. Several multidisciplinary supportive care interventions have been developed with promising results. The research summarized in this paper provides valuable insight into the psychosocial well-being of the esophageal cancer survivor. However, knowledge gaps remain, alongside a dearth of applied examples in meeting supportive care need.

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Influence of co-morbidity on long-term quality of life after oesophagectomy for cancer

Abstract: Among survivors of oesophageal cancer surgery, the presence of co-morbidity was associated with poor HRQoL over time and increasing symptoms of fatigue.

Cited by 27 publications

References 24 publications

Long-term quality of life after oesophagectomy with gastric conduit interposition for cancer

Long-term quality of life after oesophagectomy with gastric conduit interposition for cancer

Quality of life assessment in esophagectomy patients

Toward improved survivorship: supportive care needs of esophageal cancer patients, a literature review

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