Influence of coating material on the flowability and dissolution of dry-coated fine ibuprofen powders

Qu, Li; Zhou, Qi Tony; Denman, John A.; Stewart, Peter; Hapgood, Karen; Morton, David Alexander Vodden

doi:10.1016/j.ejps.2015.07.016

Cited by 42 publications

(17 citation statements)

References 41 publications

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“…Data from previous studies also showed L-leucine formed a patch-like coating that was not as uniform as MgSt. 39 For the silica-mechanofused particles (Fig. 4d), a fine lumpy texture was observed on the surfaces of both individual particles and whole agglomerates, which was in agreement with the earlier finding.…”

Section: Scanning Electron Microscopysupporting

confidence: 92%

“…52 As indicated in our previous studies, the enhanced dissolution was attributed to a reduced drug agglomeration strength and resulting better dispersion in the dissolution media. 39 The tablets made with the silica-mechanofused powder did not dissolve fully over the time duration of 60 min, which was consistent with the results from the disintegration tests. Although silica can provide good flow enhancement, it does not facilitate other tablet properties, such as tablet ejection, disintegration, and dissolution.…”

Section: Disintegration Of Tabletssupporting

confidence: 84%

“…Table 3 shows that particle size distributions of the mechanofused formulations are slightly smaller than the control batch as measured by laser diffraction, which is in agreement with our previous observations that a reduced formation of hardagglomerates existing in the particles after dry coating 38 and the consequence of particle attrition during the high-shear processing or dry dispersion. 39 The particle size data also indicate that any change in bulk flow performance by coating with additives was not achieved by enlarging particle size. Table 4 shows that the particle size distributions measured by Morphologi G3 were much larger than those measured by laser diffraction.…”

Section: Powder Flow Propertiesmentioning

confidence: 97%

“…4d), a fine lumpy texture was observed on the surfaces of both individual particles and whole agglomerates, which was in agreement with the earlier finding. 39 These structures show that silica acts to increase surface roughness as small rigid nano-sized beads to improve powder flowability. 35 Despite the low melting point of ibuprofen, no visible evidence of any significant melting phenomenon was observed for any samples after mechanofusion, which is consistent with the results from a previous mechanofusion study.…”

Section: Scanning Electron Microscopymentioning

confidence: 98%

See 3 more Smart Citations

Single-step Coprocessing of Cohesive Powder via Mechanical Dry Coating for Direct Tablet Compression

Stewart

Hapgood

et al. 2017

Journal of Pharmaceutical Sciences

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Section: Scanning Electron Microscopysupporting

confidence: 92%

Section: Disintegration Of Tabletssupporting

confidence: 84%

Section: Powder Flow Propertiesmentioning

confidence: 97%

Section: Scanning Electron Microscopymentioning

confidence: 98%

See 2 more Smart Citations

Single-step Coprocessing of Cohesive Powder via Mechanical Dry Coating for Direct Tablet Compression

Stewart

Hapgood

et al. 2017

Journal of Pharmaceutical Sciences

Self Cite

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“…There have been several studies looking at improved flowability of pharmaceutical active ingredients (APIs) using dynamic powder flow testers. Qu et al (2015) reported that coating the surface of cohesive ibuprofen with flow aids (i.e. silica or magnesium stearate) improves the flowability, as measured by the FT4 rheometer aeration test.…”

Section: Powder Mixturesmentioning

confidence: 99%

Cohesive Powder Flow: Trends and Challenges in Characterisation and Analysis

Ghadiri

Nan

Hare

et al. 2020

KONA

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Powder processing and manufacturing operations are rate processes for which the bottleneck is cohesive powder flow. Diversity of material properties, particulate form, and sensitivity to environmental conditions, such as humidity and tribo-electric charging, make its prediction very challenging. However, this is highly desirable particularly when addressing a powder material for which only a small quantity is available. Furthermore, in a number of applications powder flow testing at low stress levels is highly desirable. Characterisation of bulk powder failure for flow initiation (quasi-static) is well established. However, bulk flow parameters are all sensitive to strain rate with which the powder is sheared, but in contrast to quasi-static test methods, there is no shear cell for characterisation of the bulk parameters in the dynamic regime. There are only a handful of instruments available for powder rheometry, in which the bulk resistance to motion can be quantified as a function of the shear strain rate, but the challenge is relating the bulk behaviour to the physical and mechanical properties of constituting particles. A critique of the current state of the art in characterisation and analysis of cohesive powder flow is presented, addressing the effects of cohesion, strain rate, fluid medium drag and particle shape.

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On the Breakage of High Aspect Ratio Crystals in Filter Beds under Continuous Percolation

et al. 2020

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Purpose This work details experimental observations on the effect of liquid flow percolating through packed beds of crystals to elucidate how the filtration pressure severely alters the size distribution and crystal shape. Pressure filtration is widely used in the pharmaceutical industry, and frequently results in undesired size distribution changes that hinder further processing. Methods The percolation methodology presented fixes fluid flow through a bed of crystals, resulting in a pressure over the bed. X-ray computed tomography (XCT) provided detailed observations of the bed structure. Detailed 2D particle size data was obtained using automated microscopy and was analysed using an in-house developed tool. Results Crystal breakage is observed when the applied pressure exceeds a critical pressure: 0.5–1 bar for ibuprofen, 1–2 bar for β-L glutamic acid (LGA) and 2–2.5 bar for para amino benzoic acid (PABA). X-ray computed tomography showed significant changes in bed density under the applied pressure. Size analysis and microscope observations showed two modes of breakage: (i) snapping of long crystals and (ii) shattering of crystals. Conclusion LGA and PABA have a similar breakage strength (50 MPa), ibuprofen is significantly weaker (9 MPa). Available breakage strength data may be correlated to the volumetric Gibbs free energy. Data from 12 and 35 mm bed diameters compares well to literature data in a 80 mm filter; the smaller, easy to operate percolation unit is a versatile tool to assess crystal breakage in filtration operations.

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Influence of coating material on the flowability and dissolution of dry-coated fine ibuprofen powders

Cited by 42 publications

References 41 publications

Single-step Coprocessing of Cohesive Powder via Mechanical Dry Coating for Direct Tablet Compression

Single-step Coprocessing of Cohesive Powder via Mechanical Dry Coating for Direct Tablet Compression

Cohesive Powder Flow: Trends and Challenges in Characterisation and Analysis

On the Breakage of High Aspect Ratio Crystals in Filter Beds under Continuous Percolation

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