Influence of computed tomography contrast agent on radiotherapy dose calculation for pancreatic carcinoma: A dosimetric study based on tomotherapy and volumetric-modulated arc therapy techniques

Zhu, Feng; Wu, Weizhang; Zhu, Fuhai; Wang, Yong; Wang, Yingjie; Xia, Tingyi

doi:10.1016/j.meddos.2017.07.008

Cited by 3 publications

(5 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Considering the different algorithms employed, there was no significant influence in dose calculation due to the use of contrast agents in CT scans, corroborating previously published data for head and neck (12), esophagus (24) (25), lungs (26), and pancreas (23). Ramm et al and Shibamoto reported how the applied contrast could influence dose calculation.…”

Section: Discussionsupporting

confidence: 84%

“…Ramm et al and Shibamoto reported how the applied contrast could influence dose calculation. They demonstrated a decrease in the influence by increasing the number of fields used in planning (10,23,27). This observation is under the data of this work that used modulated treatment techniques in several fields that did not suffer the influence of contrast agents.…”

Section: Discussionmentioning

confidence: 56%

“…Delineation for PTV is improved by contrast using CT performed for treatment simulation. On the other hand, dose calculation can be affected by density changes in CT due to higher attenuation of the contrasted tissues when compared to the density of the tissue without contrast (21)(22)(23).…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Planning Head and Neck radiotherapy in contrast CT: viability for AAA and AcurosXB

et al. 2022

View full text Add to dashboard Cite

Background and purpose: many radiotherapy services execute two computed tomography (CT) scans for the treatment of head and neck (H&N) tumors: with (contrast CT) or without contrast (non-contrast CT), for dose calculation and target volume delineation, respectively. However, performing two CT scans brings problems such as unnecessary exposure of the patient to radiation and errors in CT images fusion. Therefore, the objective of this study was to verify the possibility of performing only the contrast CT as the routine for dose calculation with AAA and AcurosXB. Materials and methods: contrast and non-contrast CT scans from 77 patients were retrospectively analyzed and the Hounsfield Unit (HU) values of the target volume and some organs at risk (as well as dosimetric values were evaluated and compared. Statistical analysis was performed by calculating the intraclass correlation coefficient (ICC), assuming a significance level of 5%. Results: there is a correlation between the values obtained for both HU and dosimetric data between the CT scans since the ICC was close to 1 and the p-value was lower than 0.05 for all cases. Conclusion: it is possible to perform only the contrast CT in the simulation routine for the treatment of patients with head and neck tumors. Keywords: Radiotherapy; Computed tomography; Contrast Agent; Dose Calculation; AAA; AcurosXB; VMAT; IMRT

show abstract

Section: Discussionsupporting

confidence: 84%

Section: Discussionmentioning

confidence: 56%

See 1 more Smart Citation

Planning Head and Neck radiotherapy in contrast CT: viability for AAA and AcurosXB

et al. 2022

View full text Add to dashboard Cite

show abstract

“…[ 1 , 3 ] In the present study with 47 rectal cancer patients who received VMAT irradiation to the pelvis, we found that the influence of ICA on absolute dose was minor, which corresponds to the literatures. [ 4 , 9 , 11 , 14 – 27 ] However, with OCA, the actual dose administered to the PTV and bowels was significantly higher than planned. In contrast to ICAs, which get diluted in serum, OCAs accumulate almost exclusively in the bowel at considerable amounts, which makes a dosimetric re-evaluation necessary.…”

Section: Discussionmentioning

confidence: 99%

Oral contrast agents lead to underestimation of dose calculation in volumetric-modulated arc therapy planning for pelvic irradiation

Jiang

Tian

Tang

et al. 2020

Chinese Medical Journal

View full text Add to dashboard Cite

show abstract

“…In the general population, pancreas volume increases linearly with age during childhood and adolescence, reaches a plateau from age 20 to 60 years, and then declines thereafter [6]. Several pathological conditions (e.g., chronic pancreatitis, diabetes, and carcinoma) affected pancreatic morphology [5–9]. Pancreatic morphology in patients with diabetes has been widely studied.…”

Section: Introductionmentioning

confidence: 99%

Association between Pancreatic Atrophy and Loss of Insulin Secretory Capacity in Patients with Type 2 Diabetes Mellitus

Lü

Guo

Wang

et al. 2019

Journal of Diabetes Research

View full text Add to dashboard Cite

Aims. To examine pancreatic volume (PV) changes among patients with different duration of type 2 diabetes and whether pancreatic atrophy was associated with loss of insulin secretory capacity. Methods. This cross-sectional study (203 patients with type 2 diabetes, 93 controls without diabetes) was conducted from January 2016 to December 2017. Patients with type 2 diabetes were divided into 3 groups: recently diagnosed (duration≤2 years), midterm (duration 3-9 years), and long term (duration≥10 years). All the patients were scanned with upper abdominal computerized tomography; PV was then calculated by an experienced technician. Absolute insulin deficiency was defined as fasting C−peptide<0.9 ng/mL. Results. Compared with PV (cm3) in the controls, the mean PV was similar in patients with recently diagnosed type 2 diabetes (68.8 versus 71.0, P=0.56) but significantly reduced in patients with midterm (68.8 versus 60.8, P<0.05) and long-term (68.8 versus 53.1, P<0.001) type 2 diabetes. A similar trend was observed for the PV index (PV adjusted for body surface area and body mass index). Furthermore, rates of pancreatic atrophy and absolute insulin deficiency increased with duration of diabetes. Multiple logistic regression analysis indicated that pancreatic atrophy was associated with higher likelihood of absolute insulin deficiency (odds ratio=4.47, 95%confidence interval=1.45‐13.8). Conclusions. PV was reduced in those with midterm and long-term type 2 diabetes compared to individuals without type 2 diabetes. Overall, pancreatic atrophy was associated with the loss of insulin secretory capacity in patients with type 2 diabetes.

show abstract

Influence of computed tomography contrast agent on radiotherapy dose calculation for pancreatic carcinoma: A dosimetric study based on tomotherapy and volumetric-modulated arc therapy techniques

Cited by 3 publications

References 26 publications

Planning Head and Neck radiotherapy in contrast CT: viability for AAA and AcurosXB

Planning Head and Neck radiotherapy in contrast CT: viability for AAA and AcurosXB

Oral contrast agents lead to underestimation of dose calculation in volumetric-modulated arc therapy planning for pelvic irradiation

Association between Pancreatic Atrophy and Loss of Insulin Secretory Capacity in Patients with Type 2 Diabetes Mellitus

Contact Info

Product

Resources

About