Influence of constant positive airway pressure therapy on lipid storage, muscle metabolism and insulin action in obese patients with severe obstructive sleep apnoea syndrome

Trenell, Michael I.; Ward, Julie; Yee, Brendon J.; Phillips, Craig L.; Kemp, Graham J.; Grunstein, Ron; Thompson, Campbell

doi:10.1111/j.1463-1326.2006.00649.x

Cited by 94 publications

(76 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Two studies showed that CPAP can reduce the amount of visceral fat [7,8]. However, our negative findings are in agreement with two previous studies [4,9].…”

Section: Sleep-related Disorders I Kritikou Et Alcontrasting

confidence: 37%

See 1 more Smart Citation

Sleep apnoea and visceral adiposity in middle-aged male and female subjects

et al. 2012

View full text Add to dashboard Cite

In obese male subjects, visceral adiposity has been associated with obstructive sleep apnoea (OSA), while studies in overweight males and females are limited. Our goal was to examine the association between OSA and visceral fat in a relatively nonobese population and assess the effects of 2 months placebo-controlled continuous positive airway pressure (CPAP) use on abdominal fat.81 subjects, 22 middle-aged males and 20 post-menopausal females with OSA, and 19 male and 20 female controls were studied in the sleep laboratory for four nights. Abdominal (visceral (VAT) and subcutaneous (SAT) adipose tissue) and liver fat were assessed with computed tomography. OSA patients were re-assessed post-CPAP and post sham-CPAP.Apnoeic males had significantly higher VAT than controls, while apnoeic females had higher SAT than controls. In both sexes, OSA was associated with increased liver fat. In males, apnoea was associated with VAT whereas in females it was associated with subcutaneous, visceral and total fat. CPAP did not affect abdominal and liver fat.In overweight males, visceral adiposity is associated with OSA whereas in females it is associated with global adiposity. In overweight males, our therapeutic goal should be the reduction of visceral adiposity and its metabolic correlates, whereas, in females, weight loss may be sufficient. Shortterm CPAP treatment does not affect general, abdominal or intra-hepatic adiposity.

show abstract

“…Two studies showed that CPAP can reduce the amount of visceral fat [7,8]. However, our negative findings are in agreement with two previous studies [4,9].…”

Section: Sleep-related Disorders I Kritikou Et Alcontrasting

confidence: 37%

“…This Japanese study included a very small number of nonobese females, which did not allow for an appropriate analysis stratified by sex. Additionally, the very few studies on continuous positive airway pressure (CPAP) effects on body composition are primarily in obese males, and the results are contradictory [4,[7][8][9]]. …”

mentioning

confidence: 99%

Sleep apnoea and visceral adiposity in middle-aged male and female subjects

et al. 2012

View full text Add to dashboard Cite

show abstract

“…CPAP therapy has also been associated with reductions in visceral fat and total cholesterol and increased HDL. 106 As for OSA patients with concomitant type 2 diabetes, CPAP therapy has been linked to better glycemic control and improved insulin sensitivity, although these results have not been consistent. 107 -109 Finally, CPAP has been associated with attenuation in infl ammatory biomarkers and perhaps even improved endothelial function.…”

Section: Cpap Treatment Of Osamentioning

confidence: 81%

Interactions Between Obesity and Obstructive Sleep Apnea

Romero‐Corral

Caples

López-Jiménez

et al. 2010

Chest

668

354

View full text Add to dashboard Cite

Obstructive sleep apnea (OSA) adversely affects multiple organs and systems, with particular relevance to cardiovascular disease. Several conditions associated with OSA, such as high BP, insulin resistance, systemic infl ammation, visceral fat deposition, and dyslipidemia, are also present in other conditions closely related to OSA, such as obesity and reduced sleep duration. Weight loss has been accompanied by improvement in characteristics related not only to obesity but to OSA as well, suggesting that weight loss might be a cornerstone of the treatment of both conditions. This review seeks to explore recent developments in understanding the interactions between body weight and OSA. Weight loss helps reduce OSA severity and attenuates the cardiometabolic abnormalities common to both diseases. Nevertheless, weight loss has been hard to achieve and maintain using conservative strategies. Since bariatric surgery has emerged as an alternative treatment of severe or complicated obesity, impressive results have often been seen with respect to sleep apnea severity and cardiometabolic disturbances. However, OSA is a complex condition, and treatment cannot be limited to any single symptom or feature of the disease. Rather, a multidisciplinary and integrated strategy is required to achieve effective and long-lasting therapeutic success.CHEST 2010; 137( 3 ): 711 -719Abbreviations: AHI 5 apnea-hypopnea index ; CPAP 5 continuous positive airway pressure ; HDL 5 high-density lipoprotein ; OSA 5 obstructive sleep apnea

show abstract

“…Similarly, the Swedish Obesity Study reported a three-fold incidence of diabetes and hypertriglyceridaemia in patients with witnessed apnoeas compared to subjects with no OSA at 2 yrs follow-up [110]. Two studies reported that visceral fat decreased after CPAP treatment [103,111] while a more recent study [93] found no change in IR or visceral fat after CPAP for 3 months. Therefore, large longitudinal studies [102].…”

Section: Effects Of Osa Treatmentmentioning

confidence: 97%

Sleep, sleep-disordered breathing and metabolic consequences

Lévy¹,

Bonsignore²,

Eckel³

2009

Eur Respir J

295

187

View full text Add to dashboard Cite

Sleep profoundly affects metabolic pathways. In healthy subjects, experimental sleep restriction caused insulin resistance (IR) and increased evening cortisol and sympathetic activation. Increased obesity in subjects reporting short sleep duration leads to speculation that, during recent decades, decreased sleeping time in the general population may have contributed to the increasing prevalence of obesity. Causal inference is difficult due to lack of control for confounders and inconsistent evidence of temporal sequence.In the general population, obstructive sleep apnoea (OSA) is associated with glucose intolerance. OSA severity is also associated with the degree of IR. However, OSA at baseline does not seem to significantly predict the development of diabetes. Prevalence of the metabolic syndrome is higher in patients with OSA than in obese subjects without OSA. Treatment with continuous positive airway pressure seems to improve glucose metabolism both in diabetic and nondiabetic OSA but mainly in nonobese subjects.The relative role of obesity and OSA in the pathogenesis of metabolic alterations is still unclear and is intensively studied in clinical and experimental models. In the intermittent hypoxia model in rodents, strong interactions are likely to occur between haemodynamic alterations, systemic inflammation and metabolic changes, modulated by genetic background. Molecular and cellular mechanisms are currently being investigated.

show abstract

Influence of constant positive airway pressure therapy on lipid storage, muscle metabolism and insulin action in obese patients with severe obstructive sleep apnoea syndrome

Cited by 94 publications

References 47 publications

Sleep apnoea and visceral adiposity in middle-aged male and female subjects

Sleep apnoea and visceral adiposity in middle-aged male and female subjects

Interactions Between Obesity and Obstructive Sleep Apnea

Sleep, sleep-disordered breathing and metabolic consequences

Contact Info

Product

Resources

About