Influence of consumption of probiotics on the plasma lipid profile: A meta-analysis of randomised controlled trials

Guo, Zijian; Liu, X.M.; Zhang, Q.X.; Shen, Zhen; Tian, Fengwei; Zhang, H.; Sun, Zhihong; Zhang, H.P.; Chen, Wei

doi:10.1016/j.numecd.2011.04.008

Cited by 216 publications

(145 citation statements)

References 30 publications

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“…In agreement with the results reported herein, a recent meta-analysis [30] including randomised controlled trials that evaluated the effects of probiotic consumption on blood lipids in 485 participants concluded that probiotics were useful to lower total and LDL-cholesterol levels, but could not modify HDL-cholesterol and triacylglycerol levels.…”

Section: Discussionsupporting

confidence: 88%

Effect of Daily Consumption of <i> Lactobacillus reuteri </i> CRL 1098 on Cholesterol Reduction in Hypercholesterolemic Subjects

Malpeli¹,

Taranto²,

Cravero³

et al. 2015

FNS

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The effect of daily consumption of a yogurt containing Lactobacillus reuteri CRL 1098 on the lipid profile of hypercholesterolemic subjects was evaluated by performing a prospective, randomized, double-blind, cross-over placebo controlled clinical study. Participants consumed daily a yogurt containing L. reuteri CRL 1098 or a placebo for four weeks, separated by a wash-out period. Total cholesterol, triacylglycerol, high-density (HDL) and low-density (LDL) lipoprotein levels were assessed at the beginning and at the end of each period. We found a statistically significant reduction of total (−7.86 g/dl) and LDL (−7.02 g/dl) cholesterol in absolute changes (before-after) as well as a decreasing trend in the group receiving the yogurt containing L. reuteri with respect to the placebo group, without detecting changes in HDL-cholesterol and triacylglycerol levels. Our results suggest that low amounts of yogurt (125 g/day) and low doses of the CRL 1098 strain (10 6 CFU) are sufficient to reduce total and LDL-cholesterol levels in hypercholesterolemic subjects.

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Section: Discussionsupporting

confidence: 88%

Effect of Daily Consumption of <i> Lactobacillus reuteri </i> CRL 1098 on Cholesterol Reduction in Hypercholesterolemic Subjects

Malpeli¹,

Taranto²,

Cravero³

et al. 2015

FNS

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“…In contrast to our findings, previous meta-analyses reported that probiotics effectively reduced the levels of TC and LDL cholesterol in subjects with originally high or normal lipid levels. 43,44 This discrepancy may result from the characteristics of the study group (healthy or obese subjects in previous analyses vs subjects with diabetes in our meta-analysis), the length of intervention, or the choice of probiotic strain.…”

Section: Probiotics and High-density Lipoprotein Cholesterol Levels Omentioning

confidence: 92%

Effectiveness of probiotics in type 2 diabetes: a meta-analysis

Kasińska¹,

Drzewoski²

2015

Polish Archives of Internal Medicine

103

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INTROduCTION An increasing number of studies suggest that the use of probiotics may have a beneficial effect in patients with type 2 diabetes.ObjECTIvEs The aim of the study was to assess the ability of probiotics to modify selected cardiometabolic risk factors in subjects with type 2 diabetes.METhOds PubMed, Embase, Cochrane Library, and Scopus databases were thoroughly reviewed up to January 2015 to search for randomized controlled trials (RCTs) that examined the effect of probiotics on selected modifiable cardiometabolic parameters in patients with type 2 diabetes. The following endpoints were considered: fasting plasma glucose (FPG), insulin concentration, insulin resistance, hemoglobin A 1c (HbA 1c ), as well as the levels of total cholesterol, triglycerides, low-density and high-density lipoprotein cholesterols, and C-reactive protein (CRP). A total of 571 RCTs were initially identified, of which 8 trials with 438 individuals were selected for meta-analysis. The effects of probiotics were calculated for each parameter. REsuLTsThe meta-analysis showed a significant effect of probiotics on reducing HbA 1c levels (standardized mean difference [SMD], -0.81; confidence interval [CI], -1.33 to -0.29, P = 0.0023; I 2 = 68.44%; P = 0.0421 for heterogeneity) and HOMA-IR (SMD, -2.10; CI -3.00 to -1.20, P <0.001; I 2 = 82.91%; P = 0.0029 for heterogeneity). Supplementation with probiotics did not have a significant effect on FPG, insulin, and CRP levels as well as the lipid profile.CONCLusIONs Our meta-analysis suggests that probiotic supplementation might improve, at least to some extent, metabolic control in subjects with type 2 diabetes. However, larger well-designed, longterm RCTs are needed to confirm any potentially beneficial relationship between the use of probiotics and modifiable cardiometabolic risk factors in patients with type 2 diabetes.

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“…It is likely that these alterations play a role in the accumulation of LDL-cholesterol and disease pathogenesis. The accumulation of plasma cholesterol can also be moderated by diet, while pharmaceutical and pre-and probiotic administration have largely been associated with reduced LDLcholesterol levels and CVD risk (9)(10)(11)(12)(13) .…”

mentioning

confidence: 99%

Investigating cholesterol metabolism and ageing using a systems biology approach

et al. 2016

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CVD accounted for 27 % of all deaths in the UK in 2014, and was responsible for 1·7 million hospital admissions in 2013/2014. This condition becomes increasingly prevalent with age, affecting 34·1 and 29·8 % of males and females over 75 years of age respectively in 2011. The dysregulation of cholesterol metabolism with age, often observed as a rise in LDL-cholesterol, has been associated with the pathogenesis of CVD. To compound this problem, it is estimated by 2050, 22 % of the world's population will be over 60 years of age, in culmination with a growing resistance and intolerance to pre-existing cholesterol regulating drugs such as statins. Therefore, it is apparent research into additional therapies for hypercholesterolaemia and CVD prevention is a growing necessity. However, it is also imperative to recognise this complex biological system cannot be studied using a reductionist approach; rather its biological uniqueness necessitates a more integrated methodology, such as that offered by systems biology. In this review, we firstly discuss cholesterol metabolism and how it is affected by diet and the ageing process. Next, we describe therapeutic strategies for hypercholesterolaemia, and finally how the systems biology paradigm can be utilised to investigate how ageing interacts with complex systems such as cholesterol metabolism. We conclude by emphasising the need for nutritionists to work in parallel with the systems biology community, to develop novel approaches to studying cholesterol metabolism and its interaction with ageing.

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Influence of consumption of probiotics on the plasma lipid profile: A meta-analysis of randomised controlled trials

Cited by 216 publications

References 30 publications

Effect of Daily Consumption of <i> Lactobacillus reuteri </i> CRL 1098 on Cholesterol Reduction in Hypercholesterolemic Subjects

Effect of Daily Consumption of <i> Lactobacillus reuteri </i> CRL 1098 on Cholesterol Reduction in Hypercholesterolemic Subjects

Effectiveness of probiotics in type 2 diabetes: a meta-analysis

Investigating cholesterol metabolism and ageing using a systems biology approach

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Influence of consumption of probiotics on the plasma lipid profile: A meta-analysis of randomised controlled trials

Cited by 216 publications

References 30 publications

Effect of Daily Consumption of &lt;i&gt; Lactobacillus reuteri &lt;/i&gt; CRL 1098 on Cholesterol Reduction in Hypercholesterolemic Subjects

Effect of Daily Consumption of &lt;i&gt; Lactobacillus reuteri &lt;/i&gt; CRL 1098 on Cholesterol Reduction in Hypercholesterolemic Subjects

Effectiveness of probiotics in type 2 diabetes: a meta-analysis

Investigating cholesterol metabolism and ageing using a systems biology approach

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Effect of Daily Consumption of <i> Lactobacillus reuteri </i> CRL 1098 on Cholesterol Reduction in Hypercholesterolemic Subjects

Effect of Daily Consumption of <i> Lactobacillus reuteri </i> CRL 1098 on Cholesterol Reduction in Hypercholesterolemic Subjects