Influence of continuous, very low-dose gamma-irradiation on the mouse immune system

Courtade, M; Caratero, A; Jozan, S.; Pipy, Bernard; Caratero, C

doi:10.1080/09553000110034621

Cited by 19 publications

(14 citation statements)

References 18 publications

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“…Significant decreases in IgG1, IgG2a, and IgG2b were reported in mice exposed to chronic low‐dose γ irradiation (43), but we did not detect a change in IgM transcription in embryos exposed to the ISS radiation environment (Fig. 5 C ).…”

Section: Discussioncontrasting

confidence: 50%

Gravity changes during animal development affect IgM heavy‐chain transcription and probably lymphopoiesis

Huin-Schohn

Guéguinou

Schenten³

et al. 2012

FASEB j.

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Our previous research demonstrated that spaceflight conditions affect antibody production in response to an antigenic stimulation in adult amphibians. Here, we investigated whether antibody synthesis is affected when animal development occurs onboard a space station. To answer this question, embryos of the Iberian ribbed newt, Pleurodeles waltl, were sent to the International Space Station (ISS) before the initiation of immunoglobulin heavy-chain expression. Thus, antibody synthesis began in space. On landing, we determined the effects of spaceflight on P. waltl development and IgM heavy-chain transcription. Results were compared with those obtained using embryos that developed on Earth. We find that IgM heavy-chain transcription is doubled at landing and that spaceflight does not affect P. waltl development and does not induce inflammation. We also recreated the environmental modifications encountered by the embryos during their development onboard the ISS. This strategy allowed us to demonstrate that gravity change is the factor responsible for antibody heavy-chain transcription modifications that are associated with NF-κB mRNA level variations. Taken together, and given that the larvae were not immunized, these data suggest a modification of lymphopoiesis when gravity changes occur during ontogeny.

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Section: Discussioncontrasting

confidence: 50%

Gravity changes during animal development affect IgM heavy‐chain transcription and probably lymphopoiesis

Huin-Schohn

Guéguinou

Schenten³

et al. 2012

FASEB j.

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“…Several studies have shown that the mass and leukocyte populations of the spleen are modified when mice are subjected to various types of radiation (41)(42)(43)(44). Significant decreases in IgG1, IgG2b, and IgG2a in mice exposed to chronic low-dose gamma irradiation have also been reported (45).…”

Section: Potential Causes Of the Spaceflight-associated Changes In Vhmentioning

confidence: 87%

Spaceflight‐associated changes in immunoglobulin VH gene expression in the amphibian Pleurodeles waltl

Bascove¹,

Huin-Schohn

Guéguinou³

et al. 2009

FASEB j.

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Understanding why the immune system is depressed during spaceflight is of obvious importance for future human deep-space missions, such as the foreseen missions to Mars. However, little is known about the effects of these flights on humoral immunity. We previously immunized adult Pleurodeles waltl (urodele amphibian) onboard the Mir space station and showed that heavy-chain variable (VH) domains of specific IgM antibodies are encoded by genes belonging to the VHII and VHVI families. We have now determined how these animals use their individual VHII and VHVI genes by screening IgM heavy-chain cDNA libraries and by quantifying IgM heavy-chain transcripts encoded by these genes. Results were compared with those obtained using control animals immunized on Earth under the same conditions as onboard Mir. Our experiments revealed an increase in the expression of IgM heavy-chain mRNAs encoded by the VHII and VHVI.C genes and a strong decrease in the expression of IgM heavy-chain mRNAs encoded by the VHVI.A and VHVI.B genes in spaceflight animals. Consequently, different heavy-chain mRNAs are expressed by spaceflight animals, demonstrating that this environment affects the humoral response. These observations may be due to a change in B-cell selection under spaceflight conditions.

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“…These findings suggested that the pattern of gene expression in CD4 + T cells was significantly modified after protracted low-dose proton irradiation, with the modifications highly dependent upon the total dose and dose rate of irradiation [115]. Very low dose rate γ-irradiation (100 mGy/year) was also reported to result in a significant decrease in levels of IgG1, IgG2b and IgG2a at 12, 18 and 24 months post irradiation respectively while the total number of B-cells within the spleen remained unchanged [116]. In addition, mouse lymphocytes subjected to LDIR were observed to have increased intracellular calcium ions and stimulated protein kinase C (PKC) activities [117].…”

Section: The Mechanisms For Ldir- or Ldrir-induced Bionegative And Bimentioning

confidence: 99%

Low-dose or low-dose-rate ionizing radiation–induced bioeffects in animal models

Tang

Loke

Khoo

2016

Journal of Radiation Research

120

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Animal experimental studies indicate that acute or chronic low-dose ionizing radiation (LDIR) (≤100 mSv) or low-dose-rate ionizing radiation (LDRIR) (<6 mSv/h) exposures may be harmful. It induces genetic and epigenetic changes and is associated with a range of physiological disturbances that includes altered immune system, abnormal brain development with resultant cognitive impairment, cataractogenesis, abnormal embryonic development, circulatory diseases, weight gain, premature menopause in female animals, tumorigenesis and shortened lifespan. Paternal or prenatal LDIR/LDRIR exposure is associated with reduced fertility and number of live fetuses, and transgenerational genomic aberrations. On the other hand, in some experimental studies, LDIR/LDRIR exposure has also been reported to bring about beneficial effects such as reduction in tumorigenesis, prolonged lifespan and enhanced fertility. The differences in reported effects of LDIR/LDRIR exposure are dependent on animal genetic background (susceptibility), age (prenatal or postnatal days), sex, nature of radiation exposure (i.e. acute, fractionated or chronic radiation exposure), type of radiation, combination of radiation with other toxic agents (such as smoking, pesticides or other chemical toxins) or animal experimental designs. In this review paper, we aimed to update radiation researchers and radiologists on the current progress achieved in understanding the LDIR/LDRIR-induced bionegative and biopositive effects reported in the various animal models. The roles played by a variety of molecules that are implicated in LDIR/LDRIR-induced health effects will be elaborated. The review will help in future investigations of LDIR/LDRIR-induced health effects by providing clues for designing improved animal research models in order to clarify the current controversial/contradictory findings from existing studies.

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Influence of continuous, very low-dose gamma-irradiation on the mouse immune system

Cited by 19 publications

References 18 publications

Gravity changes during animal development affect IgM heavy‐chain transcription and probably lymphopoiesis

Gravity changes during animal development affect IgM heavy‐chain transcription and probably lymphopoiesis

Spaceflight‐associated changes in immunoglobulin VH gene expression in the amphibian Pleurodeles waltl

Low-dose or low-dose-rate ionizing radiation–induced bioeffects in animal models

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