Influence of copper and iron on subacute cadmium intoxication in protein-malnourished rats

Tewari, Prakash C.; Kachru, D.N.; Tandon, S. K.

doi:10.1016/s0013-9351(86)80167-0

Cited by 5 publications

(1 citation statement)

References 25 publications

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“…Malnourished animals showed more marked effect with decreased This observation is supported by the fact that renal tissue levels of ALP, GOT and GPT decreased significantly in Cd exposed rats of either dietary group. The significant inhibition in the activities of renal GOT and GPT upon Cd feeding is an indication of Cd nephrotoxicity [22]. High acid and alkaline phosphatase activities have been reported in rats fed on protein deficient diets [23].…”

Section: Discussionmentioning

confidence: 99%

Studies on Hepato and Renal Toxicity of Cadmium on Normal and Protein Malnourished Rats

Husain¹

2013

J Material Sci Eng

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Cadmium is an established toxic metal with its ability to accumulate in blood, liver and kidney. It adversely affects the renal cortex and ultimately leads to the renal failure. It has been reported that deficiency of certain dietary components affects cadmium toxicity. Present study was designed to evaluate the cadmium toxicity (50 ppm in drinking water) in protein malnourished group (8%) and on normal protein (21%) diet groups. It was found that Cd exposure led to marked elevation in alkaline phosphatase, acid phosphatase, glutamic pyruvic transferase, glutamic oxaloacetic acid transferase with significant increase in protein malnourished group (p 0.005). Same trend of result was noted in urinary concentration of alpha amino acid, albumin, total protein and glucose. Results were more significant (p 0.001) in malnourished animals. However, hepatic and renal enzymes showed depletion in all groups. There was marked increase in serum enzymes GOT, GPT, alkaline phosphatase, acid phosphatase in low protein diet + Cd (p 0.001). Hence present findings strongly support that protein under-nutrition predisposes the organism to the deleterious effects of cadmium toxicity.

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Section: Discussionmentioning

confidence: 99%

Studies on Hepato and Renal Toxicity of Cadmium on Normal and Protein Malnourished Rats

Husain¹

2013

J Material Sci Eng

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A comparison of the effects of dietary cadmium on heart and kidney antioxidant enzymes: Evidence for the greater vulnerability of the heart to cadmium toxicity

Jamall

Naik

Sprowls

et al. 1989

J of Applied Toxicology

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This study demonstrates the greater susceptibility of the heart as compared to the kidney to cadmium in the presence of high dietary selenium. Male weanling rats were fed an adequate-copper low-selenium feed supplemented with 0, 10 or 50 ppm copper with or without 50 ppm dietary cadmium for 7 weeks. All rats received 0.5 ppm selenium in their drinking water. Cadmium treatment resulted in histopathological lesions in the heart, but not in the kidney. Although cadmium treatment resulted in more extensive effects on glutathione peroxidase and superoxide dismutase in the heart as compared to the kidney, no increase in peroxidation was noted in either organ, suggesting that cadmium cardiotoxicity can be dissociated from tissue peroxidation. Mean cadmium concentrations in the heart ranged from 0.55 to 1.22 micrograms cadmium g-1 tissue, wet weight, and in the kidney from 11.53 to 21.04 micrograms cadmium g-1 tissue, wet weight. In both tissues examined, cadmium levels were influenced by dietary copper and heart cadmium concentrations did not correlate with either the biochemical or histological lesions observed. Thus, tissue cadmium levels alone may not be adequate for predicting cadmium toxicity.

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Comparison of cadmium, mercury and calcium accumulations by isolated hepatocytes of the small skate (Raja erinacea) and rat

Blazka

Yoshida

Shaikh

1992

Comparative Biochemistry and Physiology Part C: Comparative Pha

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Influence of copper and iron on subacute cadmium intoxication in protein-malnourished rats

Cited by 5 publications

References 25 publications

Studies on Hepato and Renal Toxicity of Cadmium on Normal and Protein Malnourished Rats

Studies on Hepato and Renal Toxicity of Cadmium on Normal and Protein Malnourished Rats

A comparison of the effects of dietary cadmium on heart and kidney antioxidant enzymes: Evidence for the greater vulnerability of the heart to cadmium toxicity

Comparison of cadmium, mercury and calcium accumulations by isolated hepatocytes of the small skate (Raja erinacea) and rat

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