Influence of Cr(III) and Cr(VI) on the interaction between sparfloxacin and calf thymus DNA

Synthesis, crystal structure and DNA-binding studies of the Ln(III) complex with 6-hydroxychromone-3-carbaldehyde benzoyl hydrazone

“…The metal ion type and its valence, which are responsible for the geometry of the complexes, also affect the intercalating ability of metal complexes to DNA [6,7]. Specifically, we have previously found that a lanthanide complex of La(III) showed a marked increase in binding affinity [8], and it has also been found that other lanthanides bind to [9][10][11][12][13][14][15][16][17], and even destroy DNA [18].…”

DNA-bound metal ions: recent developments

“…This is explained by the ability of Cr(III) to bind mainly to DNA bases at low concentrations and bind to phosphate groups at higher concentrations, thus increasing the SPFX-DNA binding constant. While Cr(VI) coordinates with SPFX, it does not have a high affinity for DNA, and the presence of Cr(VI) had no effect on the binding constant between SPFX and DNA (48). The binding interaction between SPFX and DNA decreases in the presence of Cd 2+ , which is reported to bind mainly to DNA bases, indicating that Cd 2+ competes with SPFX for DNA binding sites (72).…”

“…Cu(II) has been reported to exhibit preferential binding at polyguanosine sequences with at least two adjacent G bases (16), and DNA-fiber electron paramagnetic resonance (EPR) spectroscopy has demonstrated that aqueous Cu(II) can bind to DNA in both a mobile mode and a mode in which the orientation of the coordination plane is fixed (47). Cr(III) is generally believed to bind to DNA through the G base and an adjacent phosphate group (43,48).…”

The effect of treatment stages on the coking wastewater hazardous compounds and their toxicity

“…Using the results of the fluorescence quenching experiment in the fluorescence static quenching formula lg(F 0 − F)/F = lg k + n lg[Q] [17], the binding constants and binding sites between refractory organics in the coking wastewater and the enzyme proteins can be calculated. In the formula, F 0 is the fluorescence intensity of the coking wastewater, F is the fluorescence intensity of the coking wastewater after the enzyme protein is added in different concentrations, k is the apparent binding constant between the refractory organics in the wastewater and the enzyme protein, n is the binding sites number, and [Q] is the concentration of the enzyme protein.…”

“…While in the static quenching process, fluorescent molecules and quencher molecules in the system form ground state complexes. Raising the temperature leads to a reduction in the stability of the complexes so that the fluorescence quenching rate decreases [17]. The results of the determination test are shown in Table 5.…”