Influence of curcumin on glycemic profile, inflammatory markers, and oxidative stress in HIV‐infected individuals: A randomized controlled trial

Abstract

To evaluate the influence of curcumin supplementation on the glycemic profile, inflammatory markers, and oxidative stress in HIV‐infected individuals under antiretroviral therapy. This double‐blind, crossover, randomized clinical trial was composed of 20 subjects arranged initially into experimental group (n = 10) and placebo group (n = 10) groups, receiving 1,000 mg curcumin/day or microcrystalline cellulose/day, respectively, during a 30‐day period and 12‐day washout. Subsequently, the groups were switched to follow the crossover design. Fasting glucose and insulin, IL‐10, tumor necrosis factor alpha, malonialdehyde, and reduced glutathione were measured. Food consumption was evaluated as a control variable. Descriptive statistics are presented as mean and standard deviation, and inferential analyses were performed from two‐way analysis of variance and the magnitude of the effect. No significant improvements were observed in the glycemic, inflammatory, or oxidative stress profiles. Although the mean serum fasting glucose levels and the homeostatic model assessment index presented qualitative improvement in the CG, this result should be interpreted with caution since the observed variation may represent acceptable fluctuation, in addition to the small difference between the means, added to the large variation observed in the standard deviation. Supplementation with curcumin in HIV‐infected individuals undergoing antiretroviral therapy and training did not improve the glycemic, inflammatory, or oxidative stress profiles.

Nano-curcumin supplementation in critically ill patients with sepsis: a randomized clinical trial investigating the inflammatory biomarkers, oxidative stress indices, endothelial function, clinical outcomes and nutritional status

“…They demonstrated that curcumin supplementation did not considerably improve the glycemic profile, inflammatory indices, and oxidative stress level of HIV-infected patients. 26 Among the nutritional variables which were assessed in the current trial, serum albumin, pre-albumin, and transferrin levels did not change significantly between the study groups. However, total lymphocyte count showed a significant increase in the NC group compared to the placebo group.…”

“…In addition, the APACHE II and NUTRIC scores were notably improved in patients with traumatic brain injury after treatment with curcuminoids. 39 Furthermore, in contrast to earlier studies, Silva et al , 26 in a double-blind, crossover, randomized clinical trial study, examined the impacts of curcumin administration (1000 mg day −1 for 1 month) on the glycemic profile, inflammatory indices, and oxidative stress level in HIV-infected patients receiving antiretroviral treatments. They demonstrated that curcumin supplementation did not considerably improve the glycemic profile, inflammatory indices, and oxidative stress level of HIV-infected patients.…”

“…They demonstrated that curcumin supplementation did not considerably improve the glycemic profile, inflammatory indices, and oxidative stress level of HIV-infected patients. 26…”

“…20 A growing body of evidence has shown that curcumin exerts various pharmaceutical and therapeutic activities including antioxidant, anti-inflammatory, analgesic, anti-cancer, antimicrobial, and antiseptic effects by downregulation of lipid peroxidation, elevation of intracellular antioxidant levels, free-radical scavenging, attenuation of NF-κB and Nrf-2 signaling pathways, prevention of the synthesis of vascular endothelial growth factor (VEGF), and inhibition of lipopolysaccharide (LPS)-mediated induction of cyclooxygenase-2 expression. 21–26 Despite these advantages, one of the major problems with oral curcumin administration is its poor bioavailability and rapid metabolism. 27 However, there are several methods to increase the solubility of curcumin and enhance its bioavailability, including the use of liposomes and, more recently, nanoparticles – formulations of nano-curcumin including nanomicelles, nonpolar sandwich technology, solid lipid particle formulations, and complexing curcuminoids with piperine or phospholipids.…”

“…20 A growing body of evidence has shown that curcumin exerts various pharmaceutical and therapeutic activities including antioxidant, anti-inflammatory, analgesic, anticancer, antimicrobial, and antiseptic effects by downregulation of lipid peroxidation, elevation of intracellular antioxidant levels, free-radical scavenging, attenuation of NF-κB and Nrf-2 signaling pathways, prevention of the synthesis of vascular endothelial growth factor (VEGF), and inhibition of lipopolysaccharide (LPS)-mediated induction of cyclooxygenase-2 expression. [21][22][23][24][25][26] Despite these advantages, one of the major problems with oral curcumin administration is its poor bio-Fig. 1 The mechanisms involved in the pathogenesis of sepsis.…”