Influence of Cyclosporine and Tacrolimus on Serum Uric Acid Levels in Stable Kidney Transplant Recipients

Kanbay, Mehmet; Akçay, Ali; Huddam, Bülent; Usluoğulları, Celil Alper; Arat, Z.; Özdemir, F.N.; Haberal, Mehmet

doi:10.1016/j.transproceed.2005.08.042

Cited by 59 publications

(37 citation statements)

References 8 publications

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“…In 1 study, male sex, higher body mass index, longer term pretransplant dialysis, and hypertension were associated with the development of hyperuricemia. 13 Kanbay and associates 5 reported that cyclosporine and tacrolimus both may cause hyperuricemia in adult renal transplant recipients with stable graft function. In adult renal transplant recipients with intact graft function, it also has been reported that mean UA concentrations were higher in those patients receiving cyclosporine, than were those patients receiving tacrolimus.…”

Section: Discussionmentioning

confidence: 99%

“…4 In several studies with adult renal transplant recipients, it has been reported that hyperuricemia may contribute significantly to reduced kidney transplant survival. 5 However, the data are scarce on hyperuricemia in pediatric kidney transplant recipients. Hoyer and associates 6 have described fully increased tubular reabsorption of UA in pediatric renal transplant recipients receiving CsA.…”

Section: Introductionmentioning

confidence: 99%

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Hyperuricemia in Pediatric Renal Transplant Recipients

Gökçeoğlu

Akman²,

Koyun³

et al. 2013

Exp Clin Transplant

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Objectives: We sought to evaluate the prevalence and confounding clinical variables of hyperuricemia in pediatric kidney transplant patients. Materials and Methods:We retrospectively evaluated the medical records of 151 pediatric renal transplant recipients who received their grafts at Akdeniz University Medical Faculty in Antalya, Turkey, with a follow-up longer than 6 months. This retrospective, single-center study included 117 pediatric renal transplant recipients, after we had excluded the patients with changes in immunosuppressive treatment and graft loss, who were receiving therapy with allopurinol and furosemide. Patient information and laboratory data were obtained from patient charts and an electronic hospital database. Results: Mean uric acid levels of patients were 311 ± 74 μmol/L, and 24 of all of the patients (20%) had high uric acid levels. Fifteen patients taking tacrolimus (16%), and 9 of patients taking cyclosporine (39%) had hyperuricemia. The hyperuricemia rate of patients taking cyclosporine was significantly higher than it was for those patients taking tacrolimus (P = .014). Mean levels of uric acid in patients taking cyclosporine were higher than those of patients taking tacrolimus (344 ± 62 µmol/L and 303 ± 75 μmol/L; P = .006). There was a significant positive correlation between mean uric acid concentrations, and both serum creatinine (P = .000; r=0.487) and cystatin C (P = .000; r=0.433). There was negative correlation between mean uric acid concentration and estimated glomerular filtration rate (P = .000; r=-0.417). Mean uric acid levels of patients with intact graft function (estimated glomerular filtration rate ≥ 60 mL/min/1.73 m 2 ) was lower than the patients with a low estimated glomerular filtration rate (291 ± 67 μmol/L and 353 ± 71 μmol/L; P = .000). Mean uric acid level of patients with normal body mass index was significantly lower than that of patients who were obese-overweight (301 ± 64 μmol/L vs 343 ± 94 μmol/L; P = .045). Conclusions: We found 20% of our patient group had high uric acid levels. We also found that lower glomerular filtration rate, higher serum creatinine, cystatin c, obesity, and being overweight were risk factors for hyperuricemia in pediatric renal transplant recipients.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Hyperuricemia in Pediatric Renal Transplant Recipients

Gökçeoğlu

Akman²,

Koyun³

et al. 2013

Exp Clin Transplant

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show abstract

“…We found in this study that cyclosporine is associated with 76% of the patients with increase uric acid level. But this is in contraindication to another study by Kanby M who found that uric acid level didn't differ significantly between renal transplant recipients receiving cyclosporine and non calcinurin inhibitors 36 . Also during the course of study 15% of normouricemic patients after 1 month of kidney transplant were converted at 6 months to patients having high uric acid level (data not shown).Our finding is consistent with adult kidney transplantation 37,38 and other solid organ transplantation 39,40,41 .…”

Section: Discussionmentioning

confidence: 80%

A retrospective study of hyperurecemia in renal transplant recipients

Baruah

Datta

Nath

et al. 2014

Int Jour of Biomed Res

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“…Cyclosporin A increases serum uric acid level by renal damage and/or decreased uric acid excretion. Although hyperuricemia is a well-known adverse effect of cyclosporine, tacrolimus also increases serum uric acid level [25]. On the contrary, azathioprine seems not to affect serum uric acid level.…”

Section: Cyclosporinementioning

confidence: 94%

Effects on Uric Acid Metabolism of the Drugs except the Antihyperuricemics

Moriwaki

2014

J Bioequiv Availab

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Influence of Cyclosporine and Tacrolimus on Serum Uric Acid Levels in Stable Kidney Transplant Recipients

Cited by 59 publications

References 8 publications

Hyperuricemia in Pediatric Renal Transplant Recipients

Hyperuricemia in Pediatric Renal Transplant Recipients

A retrospective study of hyperurecemia in renal transplant recipients

Effects on Uric Acid Metabolism of the Drugs except the Antihyperuricemics

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