Influence of Dairy Products on Bioavailability of Zinc from Other Food Products: A Review of Complementarity at a Meal Level

Shkembi, Blerina; Huppertz, Thom

doi:10.3390/nu13124253

Cited by 16 publications

(12 citation statements)

References 69 publications

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“…Interestingly, about 15% of the 2.0 mg per day increase in absorbed zinc was due to the effect of the milk on zinc absorption from the rest of the diet, while 85% of the increase was accounted for by zinc absorption from the milk. These data are consistent with other observations of the effects of milk or milk products on zinc bioavailability from the rest of the diet [ 99 ]. The potential of milk or milk products, and dietary protein in general, to increase zinc absorption and retention from the rest of the meal, makes these foods intriguing targets for zinc fortification.…”

Section: Trends In Zinc Fortification Strategiessupporting

confidence: 93%

Zinc Fortification: Current Trends and Strategies

Hall

King

2022

Nutrients

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Zinc, through its structural and cofactor roles, affects a broad range of critical physiological functions, including growth, metabolism, immune and neurological functions. Zinc deficiency is widespread among populations around the world, and it may, therefore, underlie much of the global burden of malnutrition. Current zinc fortification strategies include biofortification and fortification with zinc salts with a primary focus on staple foods, such as wheat or rice and their products. However, zinc fortification presents unique challenges. Due to the influences of phytate and protein on zinc absorption, successful zinc fortification strategies should consider the impact on zinc bioavailability in the whole diet. When zinc is absorbed with food, shifts in plasma zinc concentrations are minor. However, co-absorbing zinc with food may preferentially direct zinc to cellular compartments where zinc-dependent metabolic processes primarily occur. Although the current lack of sensitive biomarkers of zinc nutritional status reduces the capacity to assess the impact of fortifying foods with zinc, new approaches for assessing zinc utilization are increasing. In this article, we review the tools available for assessing bioavailable zinc, approaches for evaluating the zinc nutritional status of populations consuming zinc fortified foods, and recent trends in fortification strategies to increase zinc absorption.

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Section: Trends In Zinc Fortification Strategiessupporting

confidence: 93%

Zinc Fortification: Current Trends and Strategies

Hall

King

2022

Nutrients

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“…Other good sources of Zn include beef, and dairy products, such as milk, eggs, and cheese ( Hacisalihoglu, 2020 ). Though it is well established that the presence of high phytate ions in the diet can ultimately hinder the absorption of several essential minerals like Ca, Fe, and Zn ( Castro-Alba et al, 2019 ), improved absorption of Zn was observed when dairy products were consumed in combination with other foods with high phytate (e.g., bread, tortillas, and rice), which seemed to be associated with the presence and beneficial effects of citrate and phosphopeptides in dairy products ( Shkembi and Huppertz, 2021 ). Zn absorption occurs within the small intestine in its ionized form which is formed when Zn is released from consumed foods.…”

Section: Bioavailability Of Zincmentioning

confidence: 99%

Zinc Essentiality, Toxicity, and Its Bacterial Bioremediation: A Comprehensive Insight

et al. 2022

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Zinc (Zn) is one of the most abundantly found heavy metals in the Earth’s crust and is reported to be an essential trace metal required for the growth of living beings, with it being a cofactor of major proteins, and mediating the regulation of several immunomodulatory functions. However, its essentiality also runs parallel to its toxicity, which is induced through various anthropogenic sources, constant exposure to polluted sites, and other natural phenomena. The bioavailability of Zn is attributable to various vegetables, beef, and dairy products, which are a good source of Zn for safe consumption by humans. However, conditions of Zn toxicity can also occur through the overdosage of Zn supplements, which is increasing at an alarming rate attributing to lack of awareness. Though Zn toxicity in humans is a treatable and non-life-threatening condition, several symptoms cause distress to human activities and lifestyle, including fever, breathing difficulty, nausea, chest pain, and cough. In the environment, Zn is generally found in soil and water bodies, where it is introduced through the action of weathering, and release of industrial effluents, respectively. Excessive levels of Zn in these sources can alter soil and aquatic microbial diversity, and can thus affect the bioavailability and absorption of other metals as well. Several Gram-positive and -negative species, such as Bacillus sp., Staphylococcus sp., Streptococcus sp., and Escherichia coli, Pseudomonas sp., Klebsiella sp., and Enterobacter sp., respectively, have been reported to be promising agents of Zn bioremediation. This review intends to present an overview of Zn and its properties, uses, bioavailability, toxicity, as well as the major mechanisms involved in its bioremediation from polluted soil and wastewaters.

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“…Zinc is an essential micronutrient whose deficiency correlates strongly with an impaired immune response [ 174 ]. Main sources of zinc are seafood, cereals, turkey, and lentils [ 175 ]. Even though zinc itself is a redox-inert metal, it plays a role as an antioxidant by aiding the proper functioning of the copper/zinc-containing antioxidant enzyme SOD.…”

Section: Nutritional Factors Interfering With the Effects Of Vitamin ...mentioning

confidence: 99%

Vitamin E and Metabolic Health: Relevance of Interactions with Other Micronutrients

et al. 2022

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A hundred years have passed since vitamin E was identified as an essential micronutrient for mammals. Since then, many biological functions of vitamin E have been unraveled in both cell and animal models, including antioxidant and anti-inflammatory properties, as well as regulatory activities on cell signaling and gene expression. However, the bioavailability and physiological functions of vitamin E have been considerably shown to depend on lifestyle, genetic factors, and individual health conditions. Another important facet that has been considered less so far is the endogenous interaction with other nutrients. Accumulating evidence indicates that the interaction between vitamin E and other nutrients, especially those that are enriched by supplementation in humans, may explain at least some of the discrepancies observed in clinical trials. Meanwhile, increasing evidence suggests that the different forms of vitamin E metabolites and derivates also exhibit physiological activities, which are more potent and mediated via different pathways compared to the respective vitamin E precursors. In this review, possible molecular mechanisms between vitamin E and other nutritional factors are discussed and their potential impact on physiological and pathophysiological processes is evaluated using published co-supplementation studies.

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Influence of Dairy Products on Bioavailability of Zinc from Other Food Products: A Review of Complementarity at a Meal Level

Cited by 16 publications

References 69 publications

Zinc Fortification: Current Trends and Strategies

Zinc Fortification: Current Trends and Strategies

Zinc Essentiality, Toxicity, and Its Bacterial Bioremediation: A Comprehensive Insight

Vitamin E and Metabolic Health: Relevance of Interactions with Other Micronutrients

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