Influence of Daytime LED Light Exposure on Circadian Regulatory Dynamics of Metabolism and Physiology in Mice

Dauchy, Robert T.; Blask, David E.; Hoffman, Aaron E.; Xiang, Shulin; Hanifin, John P.; Warfield, Benjamin; Brainard, George C.; Anbalagan, Muralidharan; Dupepe, Lynell M; Dobek, Georgina L.; Belancio, Victoria P.; Dauchy, Erin M.; Hill, Steven M.

doi:10.30802/aalas-cm-19-000001

Cited by 36 publications

(36 citation statements)

References 55 publications

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“…Constant light exposure was able to influence people's behavior and health, making adverse effects on the cardiovascular system reportedly (Furlan et al, 2000;Chang et al, 2015;Reynolds et al, 2017;Benedetto and Contin, 2019;Bohmer et al, 2019). Some papers concerning the same type of light even reported opposite effects (Dauchy et al, 2019;Killgore et al, 2019;Siemiginowska and Iskra-Golec, 2019). A systematic study on constant light is of unquestionable importance for people with cardiovascular illness.…”

Section: Introductionmentioning

confidence: 99%

Constant Light Exerted Detrimental Cardiovascular Effects Through Sympathetic Hyperactivity in Normal and Heart Failure Rats

Jing¹,

Wu²,

et al. 2020

Front. Neurosci.

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It has been documented that constant light exposure exerts complicated cardiovascular effects. However, a mounting collection of conflicting results did not make it any easier for researchers and physicians to consider the role of light on cardiovascular function. This study was designed to investigate how constant light exposure (24 h light/day) influences the cardiac function in normal and heart-failure (HF) rats. In normal rats, two groups of SD rats were accustomed in 12 h light/12 h dark (LD) or 24 h light (constant light, CL) for 4 weeks. In HF rats which was induced by myocardial infarction (MI) was let recover in LD for 4 weeks. Interestingly, compared with rats in LD environment (ejection fraction, EF%: 93.64 ± 2.02 in LD, 14.62 ± 1.53 in HF-LD), constant light (2 weeks) weakened the cardiac function in normal and HF rats (EF%: 79.42 ± 2.91 in CL, 11.50 ± 1.08 in HF-CL). The levels of renal sympathetic nerve activity and c-fos expression in the rostral ventrolateral medulla (RVLM), a key region controlling sympathetic outflow, were significantly increased in normal and HF rats after

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Section: Introductionmentioning

confidence: 99%

Constant Light Exerted Detrimental Cardiovascular Effects Through Sympathetic Hyperactivity in Normal and Heart Failure Rats

Jing¹,

Wu²,

et al. 2020

Front. Neurosci.

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“…[27][28][29][30] Both in vitro and in vivo studies have shown that melatonin inhibited the growth of a variety of human and animal tumors, such as lung cancer, breast cancer, and ovarian cancer. 31,32 And some studies informed that the anti-cancer effect of MLT was influenced by dynamic circadian rhythms of metabolism and physiology in both the host and tumor. 27,28 And in previous reviews, Reiter et al have speculated that MLT disinhibited pyruvate dehydrogenase complex as a mean of inhibiting tumor growth.…”

Section: Introductionmentioning

confidence: 99%

Melatonin inhibits lung cancer development by reversing the Warburg effect via stimulating the SIRT3/PDH axis

Chen

Hao

et al. 2021

Journal of Pineal Research

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Recently, the morbidity and mortality from lung cancer have continued to increase.Mitochondrial dysfunction plays a key role in apoptosis, proliferation, and the bioenergetic reprogramming of cancer cells, especially for energy metabolism. Herein, we investigated the ability of melatonin (MLT) to influence lung cancer growth and explored the association between mitochondrial functions and the progression of lung tumors. The deacetylase, sirtuin 3 (Sirt3), is a pivotal player in maintenance of mitochondrial function, among participating in ATP production by regulating the acetylone and pyruvate dehydrogenase complex (PDH). We initially found that MLT inhibited lung cancer growth in the Lewis mouse model. Similarly, we observed that MLT inhibited the proliferation of lung cancer cells (A549, PC9, and LLC cells), and the underlying mechanism of MLT was related to reprogramming cancer cell metabolism, accompanied by a shift from cytosolic aerobic glycolysis to oxidative phosphorylation (OXPHOS). These changes were accompanied by higher ATP production, an elevated ATP production-coupled oxygen consumption rate (QCR), higher ROS levels, higher mito-ROS levels, and lower lactic acid secretion. Additionally, we observed that MLT improved mitochondrial membrane potential and the activities of complexes Ⅰ and Ⅳ in the electron transport chain. Importantly, we also found and verified that the foregoing changes resulted from activation of Sirt3 and PDH. As a result of these changes, MLT significantly enhanced mitochondrial energy metabolism to reverse the Warburg effect via increasing PDH activity with stimulation of Sirt3. Collectively, these findings suggest the potential use of melatonin as an antilung cancer therapy and provide a mechanistic basis for this proposal.

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“…As our modern society has become accustomed to the constant presence of bright light, the harmful effects of these unnatural light sources have been underestimated for the most part. Although it is known how light affects our day-and-night rhythm [ 3 ], its direct effects on the retinal tissue and corresponding functional and pathological changes have mostly been ignored. Vision is our dominant sense since more than two-thirds of the surrounding information is perceived and preprocessed by the retina.…”

Section: Introductionmentioning

confidence: 99%

LED-Induced Microglial Activation and Rise in Caspase3 Suggest a Reorganization in the Retina

Balogh

Szarka

Tengölics

et al. 2021

IJMS

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Vision is our primary sense as the human eye is the gateway for more than 65% of information reaching the human brain. Today’s increased exposure to different wavelengths and intensities of light from light emitting diode (LED) sources could induce retinal degeneration and accompanying neuronal cell death. Damage induced by chronic phototoxic reactions occurring in the retina accumulates over years and it has been suggested as being responsible for the etiology of many debilitating ocular conditions. In this work, we examined how LED stimulation affects vision by monitoring changes in the expression of death and survival factors as well as microglial activation in LED-induced damage (LID) of the retinal tissue. We found an LED-exposure-induced increase in the mRNA levels of major apoptosis-related markers BAX, Bcl-2, and Caspase-3 and accompanying widespread microglial and Caspase-3 activation. Everyday LED light exposure was accounted for in all the described changes in the retinal tissue of mice in this study, indicating that overuse of non-filtered direct LED light can have detrimental effects on the human retina as well.

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Influence of Daytime LED Light Exposure on Circadian Regulatory Dynamics of Metabolism and Physiology in Mice

Cited by 36 publications

References 55 publications

Constant Light Exerted Detrimental Cardiovascular Effects Through Sympathetic Hyperactivity in Normal and Heart Failure Rats

Constant Light Exerted Detrimental Cardiovascular Effects Through Sympathetic Hyperactivity in Normal and Heart Failure Rats

Melatonin inhibits lung cancer development by reversing the Warburg effect via stimulating the SIRT3/PDH axis

LED-Induced Microglial Activation and Rise in Caspase3 Suggest a Reorganization in the Retina

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