Influence of dearterialization on distribution of absolute tumor blood flow between hepatic artery and portal vein

Wang, Liqing; Persson, Bengt‐Arne; Bergqvist, Lennart; Bengmark, S

doi:10.1002/1097-0142(19941101)74:9<2454::aid-cncr2820740911>3.0.co;2-f

Cited by 26 publications

(14 citation statements)

References 16 publications

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“…However, even a palliative or symptomatic approach should be considered in patients with extremely poor prognosis (Wallace et al 1990;Sasson and Sigurdson 2002;Weinreich and Alexander 2002). These data can be used as a basis for prospective trial studies (Wang et al 1994;Hakansson et al 1997;Song et al 2001).…”

Section: Discussionmentioning

confidence: 99%

Preliminary experience with transarterial chemoembolization (TACE) in liver metastases of uveal malignant melanoma: local tumor control and survival

Vogl

Eichler

Zangos

et al. 2006

J Cancer Res Clin Oncol

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Section: Discussionmentioning

confidence: 99%

Preliminary experience with transarterial chemoembolization (TACE) in liver metastases of uveal malignant melanoma: local tumor control and survival

Vogl

Eichler

Zangos

et al. 2006

J Cancer Res Clin Oncol

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“…In the metastatic liver model inoculated with N-methyl-N-nitrosoguanidine-induced colonic adenocarcinoma cells, the contribution of portal blood to the liver tumor blood supply was 16% when tumors were small and declined to 4% when tumors grew larger without compensation for the withdrawal of tumor arterial blood supply after dearterialization (Wang et al, 1994). The malignant tissue in liver tumor is mostly nourished by the hepatic arterial blood.…”

Section: Discussionmentioning

confidence: 99%

Increased Estrogen Sulfation of Estradiol 17β-D-Glucuronide in Metastatic Tumor Rat Livers

Sun¹,

Liu²,

Pang³

2006

J Pharmacol Exp Ther

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Changes in the disposition of estradiol 17␤-D-glucuronide (E 2 17G), a substrate of the organic anion-transporting polypeptide family (Oatp) and multidrug resistance-associated protein 2 (Mrp2), were examined in livers of male Wag/Rij rats that were injected with CC531 cells intraportally to induce metastatic tumors (n ϭ 5) or with phosphate-buffered saline for shamoperated controls (n ϭ 4). Multiple indicator dilution, singlepass liver perfusions revealed extremely high influx clearances of [ 3 H]E 2 17G (Ͼ190 ml/min) in both groups. In recirculating liver perfusions, [ 3 H]E 2 17G decayed monoexponentially in the reservoir perfusate, and the total (9.19 Ϯ 1.33 versus 8.18 Ϯ 0.94 ml/min) and biliary (4.94 Ϯ 1.07 versus 4.60 Ϯ 0.86 ml/min) clearances were similar in both groups (P Ͼ 0.05). The metabolic clearance of E 2 17G was higher in the tumor group (4.60 Ϯ 0.64 versus 3.23 Ϯ 0.23 ml/min, P Ͻ 0.05). E 2 3S17G, the 3-sulfate metabolite, whose identity was confirmed by mass spectrometry, appeared only in bile and not perfusate. Liver microsomal incubations of E 2 3 35 S17G and [ 3 H]estrone sulfate revealed similar sulfatase activities between the tumor and sham livers, albeit the activities were much lower for E 2 3 35 S17G. Oatp1a1 and Oatp1b2 protein expression in liver membrane fragments was reduced by 42% and 38%, respectively, whereas that of cytosolic estrogen sulfotransferase (Sult1e1) was significantly increased (41%) with tumor (P Ͻ 0.05). All of the observations were captured by modeling. From modeling, we showed that reduction of the high influx clearance (546 to 283 ml/min) failed to lower the total clearance of E 2 17G, whereas up-regulation of Sult1e1 increased the E 2 17G sulfation clearance (2.56 to 3.69 ml/min) in livers with metastatic tumors.The liver mediates both the metabolism and excretion of drugs. Molecules gain access into hepatocytes where the machinery for vectorial transport and biotransformation exists. At the basolateral/sinusoidal membrane, unbound molecules in plasma are taken up by hepatocytes via organic anion/ cation transporters and/or passive diffusion. In the cell, the molecules can be metabolized by various phase I and phase II enzymes. Finally, drug precursors and metabolites are either secreted into bile by the ATP binding cassette transporters, the multidrug resistance-associated protein (MRP) 2, P-glycoprotein, and breast cancer resistance protein (BCRP), or effluxed back into the blood stream by MRP3 and MRP4.Liver tumor metastasis is a progressive invasion of malig-

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“…Multimodal treatment protocols, including TACE, RFA, and 125 I radioactive seed implantation, have been established for the treatment of metastatic tumors. Because liver metastases are little supplied by the hepatic artery, to date, TACE was developed as a palliative treatment for liver metastasis[17]. The goal of this study was to evaluate the efficacy of combining TACE with RFA and/or radioactive seed implantation on disease control and survival.…”

Section: Discussionmentioning

confidence: 99%

Efficacy of minimally invasive therapies on unresectable pancreatic cancer

Huang

Pan²,

et al. 2013

Chin J Cancer

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For patients with unresectable pancreatic cancer, current chemotherapies have negligible survival benefits. Thus, developing effective minimally invasive therapies is currently underway. This study was conducted to evaluate the efficacy of transarterial chemoembolization plus radiofrequency ablation and/or 125I radioactive seed implantation on unresectable pancreatic cancer. We analyzed the outcome of 71 patients with unresectable pancreatic carcinoma who underwent chemoembolization plus radiofrequency ablation and/or radioactive seed implantation. Of the 71 patients, the median survival was 11 months, and the 1-, 2-, and 3-year overall survival rates were 32.4%, 9.9%, and 6.6% respectively. Patients who had no metastasis, who had oligonodular liver metastases (≤3 lesions), and who had multinodular liver metastases (>3 lesions) had median survival of 12, 18, and 8 months, respectively, and 1-year overall survival rates of 50.0%, 68.8%, and 5.7%, respectively. Although the survival of patients without liver metastases was worse than that of patients with oligonodular liver metastasis, the result was not significant (P = 0.239). In contrast, the metastasis-negative patients had significantly better survival than did patients with multinodular liver metastases (P < 0.001). Patients with oligonodular liver lesions had a significanthg longer median survival than did patients with multinodular lesions (P < 0.001). In conclusion, combined minimally invasive therapies had good efficacy on unresectable pancreatic cancer and resulted in a good control of liver metastases. In addition, the number of liver metastases was a significant factor in predicting prognosis and response to treatment.

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Influence of dearterialization on distribution of absolute tumor blood flow between hepatic artery and portal vein

Cited by 26 publications

References 16 publications

Preliminary experience with transarterial chemoembolization (TACE) in liver metastases of uveal malignant melanoma: local tumor control and survival

Preliminary experience with transarterial chemoembolization (TACE) in liver metastases of uveal malignant melanoma: local tumor control and survival

Increased Estrogen Sulfation of Estradiol 17β-D-Glucuronide in Metastatic Tumor Rat Livers

Efficacy of minimally invasive therapies on unresectable pancreatic cancer

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