Influence of delaying gastric emptying on meal‐related symptoms in healthy subjects

Tack, Jan; Coulie, Bernard; Verbeke, Kristin; Janssens, J.

doi:10.1111/j.1365-2036.2006.03095.x

Cited by 17 publications

(13 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This observation was consistent with previous studies demonstrating that the delayed gastric emptying induced by PPI or other drugs (Tougas et al 2005;Tack et al 2006) was not accompanied by any dyspeptic symptoms in healthy volunteers. It has been suggested that gastric emptying has a possible pathophysiological role in eliciting dyspeptic symptoms (Stanghellini et al 1996;Sarnelli et al 2003) and this gastric motor disturbance is also partly responsible for the occurrence of gastro-esophageal reflux through gastric distension leading to transient relaxation of the lower esophageal sphincter (McCallum et al 1981;Stacher et al 2000).…”

Section: Discussionsupporting

confidence: 82%

Lack of Modulation of Gastric Emptying by Dietary Nitrate in Healthy Volunteers

Terai

Iijima

Asanuma

et al. 2009

Tohoku J. Exp. Med.

View full text Add to dashboard Cite

Section: Discussionsupporting

confidence: 82%

Lack of Modulation of Gastric Emptying by Dietary Nitrate in Healthy Volunteers

Terai

Iijima

Asanuma

et al. 2009

Tohoku J. Exp. Med.

View full text Add to dashboard Cite

“…It has been concluded that delayed gastric empting may be a disease marker rather than a determinant of severity for the 2 categories of functional dyspepsia, that is, epigastric pain and postprandial distress syndromes [66]. Consistent with this view, sumatriptane, despite causing a moderate delay of gastric emptying, even afforded some relief of individual symptoms, probably due to a relaxant effect on the proximal stomach [67]. The latter explanation is supported by the ability of buspirone, a fundus-relaxing drug, to improve symptoms and gastric accommodation compared with placebo in 17 patients with functional dyspepsia [68].…”

Section: Pepsin-induced Processes Supportive Of Digestionsupporting

confidence: 58%

Pepsin and Its Importance for Functional Dyspepsia: Relic, Regulator or Remedy?

Petersen¹

2017

Dig Dis

View full text Add to dashboard Cite

Background: Functional dyspepsia is a heterogeneous disorder lacking an established therapeutic strategy. Historical treatment attempts with pepsin products were shrugged off, as a simple calculation shows that quantitative substitution is pointless. However, such attempts might have been right for the wrong reason. Summary: Today, the role of pepsins is primarily seen in the provision of signalling amino acids (especially phenylalanine and tryptophan) and peptides, which initiate processes promoting digestion. Proteolysis benefits from pepsin variants showing, contrary to common belief, activities of up to a pH value of 5.0. Non-clinical and clinical studies support the view that liberated amino acids produce a variety of direct and indirect effects. Signal chains stimulated by (mostly aromatic) amino acids lead to secretion of gastrin and cholecystokinin (CCK), mediated, respectively, by CCK2 (gastrin) and Ca²⁺-sensing receptors in the parietal cell, and Ca²⁺-sensing receptors in the antral and duodenal mucosa. Thus, CCK effects such as secretion of pancreatic enzymes and promotion of gastric accommodation are (also) consequential to peptic liberation of amino acids. Key Message: As functional dyspepsia represents a heterogeneous disorder, it may be intriguing to view pepsin as a potential (although still to be proven) treatment modality, distinguished by a diversity of pro-digestive effects.

show abstract

“…In the antrum, the 5-HT-induced contractions were significantly inhibited by methysergide (5-HT 1 , 5-HT 2 , 5-ht 5 , 5-HT 6 and 5-HT 7 receptor antagonist), however contractions were not inhibited by either WAY-100635 (selective 5-HT 1A receptor antagonist), GR127935 (5-HT 1B/1D receptor antagonist) or SB-269970 (selective 5-HT 7 receptor antagonist), suggesting the involvement of 5-HT 2 , 5-ht 5 and 5-HT 6 receptors. The pK i values of methysergide to rat 5-ht 5 and 5-HT 6 receptors were reported to be smaller than 7, [29][30][31] therefore an inhibitory effect at 5-ht 5 and 5-HT 6 receptors by methysergide at 10 Ϫ7 M is unlikely.…”

Section: Discussionmentioning

confidence: 99%

“…The pK i values of methysergide to rat 5-ht 5 and 5-HT 6 receptors were reported to be smaller than 7, [29][30][31] therefore an inhibitory effect at 5-ht 5 and 5-HT 6 receptors by methysergide at 10 Ϫ7 M is unlikely. RS-127445 (selective 5-HT 2B receptor antagonist) slightly inhibited and 10 Ϫ6 M ketanserin (non-selective 5-HT 2 receptor antagonist) tended to inhibit the antral contractile responses to 5-HT, although these effects were not statistically significant.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Pharmacological Characterization of 5-Hydroxytryptamine-Receptor Subtypes in Circular Muscle from the Rat Stomach

Komada

Yano

2007

Biological & Pharmaceutical Bulletin

View full text Add to dashboard Cite

It is generally accepted that gastric emptying is regulated by the coordination of the proximal and distal stomach motilities. 5-HT has proven to be an important mediator of gastrointestinal motility.1,2) The stimulation of 5-HT 1B/1D receptors induces gastric accommodation in humans 3) and dogs, 4) and delays gastric emptying in humans. 5,6) The blockade of 5-HT 3 receptors inhibits gastrointestinal motility in humans. 7) In addition, the stimulation of 5-HT 4 receptors elicits gastrointestinal contractile activity and increases the rate of gastric emptying in humans 8,9) and dogs. [10][11][12] With regard to gastric smooth muscle activity, it is generally accepted that the 5-HT 1B/1D and 5-HT 7 receptors are relaxant whereas the 5-HT 2 , 5-HT 3 and 5-HT 4 receptors are contractile. Although the gastric contractility of 5-HT has been reported in a variety of species and stomach regions, regional and functional differences of 5-HT-receptor subtypes have been fully investigated only in the guinea pig stomach. [13][14][15][16] In the guinea pig stomach, the fundus presents the relaxant 5-HT 1 receptors and the contractile 5-HT 2 and 5-HT 3 receptors, the corpus presents the relaxant 5-HT 1 receptors and the contractile 5-HT 3 and 5-HT 4 receptors, and the antrum presents the contractile 5-HT 2 , 5-HT 3 and 5-HT 4 receptors. However, the in vivo studies for examining gastric motility and gastric emptying using guinea pigs are limited. On the other hand, the rat is widely used as in vivo models to study gastric motility [17][18][19] and gastric emptying rate. [20][21][22] The stimulation of 5-HT 2 receptors increases gastric motility, 17) the blockade of 5-HT 3 receptors accelerates gastric emptying, 20) and the stimulation of 5-HT 4 receptors increases gastric motility 18) and accelerates gastric emptying. 20,21) In in vitro, pharmacological characterization of the contractile response to 5-HT in the rat stomach regions still remains unclear, except for the contractile 5-HT 2B receptors in longitudinal muscle strips of the fundus. [23][24][25] The present study was, therefore, designed to provide further information regarding functions of 5-HT receptor subtypes in circular muscle strips from the antrum, corpus and fundus of the rat stomach. MATERIALS AND METHODSChemicals Carbachol (CCh), atropine sulfate monohydrate and tetrodotoxin (TTX) were purchased from Wako Pure Chemicals (Osaka, Japan). 5-Hydroxytryptamine hydrochloride (5-HT), methysergide maleate, ketanserin tartrate and SB-269970 (selective 5-HT 7 receptor antagonist) were purchased from Sigma (St. Louis, MO, U.S.A.). WAY-100635 maleate (selective 5-HT 1A receptor antagonist), GR127935 hydrochloride (5-HT 1B/1D receptor antagonist) and cinanserin hydrochloride (selective 5-HT 2 receptor antagonist) were purchased from Tocris Cookson (Ellisville, MO, U.S.A.). RS-127445 (selective 5-HT 2B receptor antagonist), ondansetron (selective 5-HT 3 receptor antagonist) and SB-203186 (selective 5-HT 4 receptor antagonist) were synthesized at Pfizer Inc. All the drugs...

show abstract

Influence of delaying gastric emptying on meal‐related symptoms in healthy subjects

Abstract: SUMMARY BackgroundAlthough delayed gastric emptying is often found in functional dyspepsia, a causal role for delayed emptying in inducing symptoms has not been demonstrated.

Cited by 17 publications

References 41 publications

Lack of Modulation of Gastric Emptying by Dietary Nitrate in Healthy Volunteers

Lack of Modulation of Gastric Emptying by Dietary Nitrate in Healthy Volunteers

Pepsin and Its Importance for Functional Dyspepsia: Relic, Regulator or Remedy?

Pharmacological Characterization of 5-Hydroxytryptamine-Receptor Subtypes in Circular Muscle from the Rat Stomach

Contact Info

Product

Resources

About