Influence of diabetes on endothelial cell response during sepsis

Schuetz, Philipp; Yano, Kimihiko; Sorasaki, Midori; Ngo, Long; Hilaire, M. St.; Lucas, Jason M.; Aird, William C.; Shapiro, Nathan I.

doi:10.1007/s00125-011-2059-y

Cited by 22 publications

(27 citation statements)

References 43 publications

(59 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Coagulation and endothelial dysfunction have been implicated in sepsis pathophysiology [18]. Sepsis outcomes are worse in obese patients as well as those with diabetes [19,20,21]. Cardiovascular disease compromises the host response to sepsis and septic shock, pointing to connections between cardiovascular and infection risk in this population [22].…”

Section: Discussionmentioning

confidence: 99%

Chronic Kidney Disease and Risk of Death from Infection

Wang¹,

Gamboa²,

Warnock³

et al. 2011

Am J Nephrol

139

View full text Add to dashboard Cite

Background: Infection, bacteremia and sepsis are major sources of morbidity and mortality in patients with end-stage renal disease. This study sought to determine the association between predialysis chronic kidney disease (CKD) and infection-related mortality. Methods: We analyzed participants in the Third National Health and Nutrition Examination Survey (NHANES III). The study included adults ≧45- years-old without end-stage renal disease. Estimated glomerular filtration rate (eGFR) was categorized as ≧60, 45–59.9 and <45 ml/min per 1.73 m², and urinary albumin-to-creatinine ratio (ACR) as <30, 30–299.9 and ≧300 mg/g. The study identified infection-related mortality, including septicemia, respiratory, abdominal and gastrointestinal, cardiac, kidney and genitourinary, neurologic, and other infections over a median of 13 years using the National Death Index. Results: Of 7,400 participants included in the study, 206 died from infections. Compared to individuals with eGFR ≧60 ml/min per 1.73 m², infection-related mortality was higher for those with lower eGFR [adjusted HR = 1.36 (95% CI: 0.81, 2.30) and 2.36 (1.04, 5.38) for eGFR of 45–59.9 and <45 ml/min per 1.73 m², respectively; p trend = 0.06]. Compared to individuals with ACR <30 mg/g, infection-related mortality was higher for ACR levels of 30–299 and ≧300 mg/g [adjusted HR = 1.68 (95% CI: 0.97, 2.92) and 2.84 (0.92, 8.74), p trend = 0.02]. Conclusions: Reduced eGFR and albuminuria are associated with increased risk for infection-related mortality. Efforts are needed to reduce its incidence and mitigate the effects of infections among individuals with CKD.

show abstract

Section: Discussionmentioning

confidence: 99%

Chronic Kidney Disease and Risk of Death from Infection

Wang¹,

Gamboa²,

Warnock³

et al. 2011

Am J Nephrol

139

View full text Add to dashboard Cite

show abstract

“…The major implication is that for a given stressor, the responses in males and females, and the resulting pathology should the stressor not be removed, are likely to differ. Multiple comorbidities such as diabetes, hypertension, and heart failure, which have already been shown to display sex differences with respect to onset, frequency, morbidity, and mortality, also impact microvascular function [4, 11, 13, 84, 93, 107]. …”

Section: Conclusion and Missing Information (Eg Future Studies Armentioning

confidence: 99%

Sex-Specific Characteristics of the Microcirculation

Huxley

Kemp

2018

Advances in Experimental Medicine and Biology

View full text Add to dashboard Cite

The requirements of metabolizing tissue are both continuous and variable; accordingly, the microvasculature serving that tissue must be similarly dynamic. Just as it is recognized that males and females of the same species have differing metabolic requirements, is it not likely that the microvasculature serving these tissues will differ by sex? This section focusing on the constituents of the microcirculation identifies what is known presently about the role sex plays in matching metabolic demand with microvascular function and areas requiring additional study. Many of the identified sex differences are subtle and easily ignored. In the aggregate, though, they can profoundly alter phenotype, especially under stressful conditions including pregnancy, exercise, and disease states ranging from diabetes to heart failure. Although the features presently identified to “have sex” range from differences in growth, morphology, protein expression, and intracellular signaling, males and females alike achieve homeostasis, likely by different means. Studies of microvascular sexual dimorphism are also identifying age as an independent but interacting factor requiring additional attention. Overall, attempting to ignore either sex and/or age is inappropriate and will prevent the design and implementation of appropriate interventions to present, ameliorate, or correct microvascular dysfunction.

show abstract

“…Endothelial activation has been implicated in the pathogenesis of sepsis [53] and diabetes is itself known to activate endothelium. A recent study of 207 sepsis patients (of whom 30% had diabetes) showed that markers of endothelial cell activation (plasma E-selectin and soluble fms-like tyrosine kinase-1 [sFLT-1]) were higher in diabetes [54]. …”

Section: Diabetes and The Immune Systemmentioning

confidence: 99%

The impact of diabetes on the pathogenesis of sepsis

Koh

Peacock

Poll

et al. 2011

Eur J Clin Microbiol Infect Dis

188

129

View full text Add to dashboard Cite

Diabetes is associated with an increased susceptibility to infection and sepsis. Conflicting data exist on whether the mortality of patients with sepsis is influenced by the presence of diabetes, fuelling the ongoing debate on the benefit of tight glucose regulation in patients with sepsis. The main reason for which diabetes predisposes to infection appears to be abnormalities of the host response, particularly in neutrophil chemotaxis, adhesion and intracellular killing, defects that have been attributed to the effect of hyperglycaemia. There is also evidence for defects in humoral immunity, and this may play a larger role than previously recognised. We review the literature on the immune response in diabetes and its potential contribution to the pathogenesis of sepsis. In addition, the effect of diabetes treatment on the immune response is discussed, with specific reference to insulin, metformin, sulphonylureas and thiazolidinediones.

show abstract

Influence of diabetes on endothelial cell response during sepsis

Cited by 22 publications

References 43 publications

Chronic Kidney Disease and Risk of Death from Infection

Chronic Kidney Disease and Risk of Death from Infection

Sex-Specific Characteristics of the Microcirculation

The impact of diabetes on the pathogenesis of sepsis

Contact Info

Product

Resources

About