2020
DOI: 10.1186/s12882-020-02113-z
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Influence of dialysate temperature on creatinine peritoneal clearance in peritoneal dialysis patients: a randomized trial

Abstract: Background Patients on continuous ambulatory peritoneal dialysis (PD) are encouraged to warm dialysate to 37 °C before peritoneal infusion; main international PD guidelines do not provide specific recommendation, and patients generally warm dialysate batches partially or do not warm them at all. Warming of dialysate is a time-consuming procedure, not free from potential risks (i.e. degradation of glucose), and should be justified by a clear clinical benefit. Methods We designed a single blind randomized cont… Show more

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Cited by 1 publication
(2 citation statements)
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“…Contrary to the environment in the pharmaceutical laboratory with constant temperature monitoring systems, the effects of temperature fluctuations and the duration outside refrigerated conditions during transportation on drug stability remain unknown. Data on the best practice for warming the PD bag prior to use remains unclear [ 110 ]. Whilst the manufacturers have recommended heating PD solutions with dry heat (i.e., heating pad), it must be noted that overheating could result in drug degradation and the formation of toxic GDP [ 110 , 111 ].…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Contrary to the environment in the pharmaceutical laboratory with constant temperature monitoring systems, the effects of temperature fluctuations and the duration outside refrigerated conditions during transportation on drug stability remain unknown. Data on the best practice for warming the PD bag prior to use remains unclear [ 110 ]. Whilst the manufacturers have recommended heating PD solutions with dry heat (i.e., heating pad), it must be noted that overheating could result in drug degradation and the formation of toxic GDP [ 110 , 111 ].…”
Section: Discussionmentioning
confidence: 99%
“…Data on the best practice for warming the PD bag prior to use remains unclear [ 110 ]. Whilst the manufacturers have recommended heating PD solutions with dry heat (i.e., heating pad), it must be noted that overheating could result in drug degradation and the formation of toxic GDP [ 110 , 111 ]. Therefore, the accidental overheating of the PD bag beyond 37 °C in the patient’s home environment, which could potentially affect the drug stability resulting in loss of pharmacological activity, cannot be ruled out.…”
Section: Discussionmentioning
confidence: 99%