Influence of diet on the induction of hepatic ceroid pigment in rats by polychlorinated biphenyls

Itokawa, Yoshinori; Yagi, Nobuya; Kono, Hiroshi; Kamohara, Kazutaka; Fujiwara, Kunisato

doi:10.1016/0041-008x(76)90033-8

Cited by 18 publications

(1 citation statement)

References 13 publications

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“…PCB ingestion also increased the 18:0 proportion of the fatty acid content in hepatic phospholipid. These findings might be the result of the activation of fatty acid synthesis, because dietary PCBs are known to increase lipid synthesis (28). The supply of 18:0 by dietary HSO and the increase of this fatty acid by PCBs were independent, and caused a 7% increase in the stearic acid ratio and a 4.6% increase in total saturated acid in the hepatic phospholipids of rats given HSO-A + PCBs compared with controls.…”

Section: Table 4 Effects Of Dietary Pcbs and Highly Hydrogenated Soybmentioning

confidence: 92%

Highly hydrogenated dietary soybean oil modifies the responses to polychlorinated biphenyls in rats

Kamei

Ohgaki

Kanbe

et al. 1996

Lipids

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The effects of dietary highly hydrogenated soybean oil (HSO) upon the changes caused by dietary polychlorinated biphenyls (PCBs) were examined in rats. Six groups of rats were fed the following diets for 30 d: a 20% soybean oil-containing diet (control diet), a diet in which a half of soybean oil was substituted with HSO (HSO-A diet), a diet in which cellulose powder was replaced with HSO (HSO-B diet) and these diets supplemented with 100 ppm PCBs (control + PCBs, HSO-A + PCBs and HSO-B + PCBs diets). Hepatic concentration of PCBs and relative liver weight were markedly decreased in rats fed with the HSO-A + PCBs diet compared with those fed with the other diets containing PCBs. Liver lipids and liver cholesterol were considerably decreased with a reciprocal increase in fecal sterol excretion by rats fed the HSO-A + PCBs and the HSO-B + PCBs diets compared with those fed with the control + PCBs diet. The fatty acid composition in hepatic phospholipids showed an independent increase of the saturated fatty acid content induced by dietary HSO and PCBs. Dietary PCBs also caused decreases in the amounts of monounsaturated and n-3 polyunsaturated fatty acids. These results suggest that dietary HSO prevents accumulation of PCBs in the liver and promotes the excretion of lipids stimulated by PCBs, accompanied by a change in fatty acid metabolism.

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Section: Table 4 Effects Of Dietary Pcbs and Highly Hydrogenated Soybmentioning

confidence: 92%

Highly hydrogenated dietary soybean oil modifies the responses to polychlorinated biphenyls in rats

Kamei

Ohgaki

Kanbe

et al. 1996

Lipids

View full text Add to dashboard Cite

show abstract

Effect of difference in diet composition on the toxicity of polychlorinated biphenyls

Yagi

Kamohara

Itokawa

1985

Bull. Environ. Contam. Toxicol.

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Sodium, potassium, magnesium and calcium levels in polychlorinated biphenyl (PCB) poisoned rats

Yagi

Kimura

Itokawa

1976

Bull. Environ. Contam. Toxicol.

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Influence of diet on the induction of hepatic ceroid pigment in rats by polychlorinated biphenyls

Cited by 18 publications

References 13 publications

Highly hydrogenated dietary soybean oil modifies the responses to polychlorinated biphenyls in rats

Highly hydrogenated dietary soybean oil modifies the responses to polychlorinated biphenyls in rats

Effect of difference in diet composition on the toxicity of polychlorinated biphenyls

Sodium, potassium, magnesium and calcium levels in polychlorinated biphenyl (PCB) poisoned rats

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