Influence of dietary artemisinin supplementation on productive performance and haematological parameters of broiler chickens

Abstract

-In the present study, we aimed to assess the toxicity of artemisinin on the haematological system and its effect on the productive performance of broiler chickens. Eighteen-day-old chickens were randomly divided into four groups of 30 chickens (three replicates of 10 broilers/group): control group and three experimental groups: ART5 -diet with 5 ppm of artemisinin; ART50 -diet with 50 ppm of artemisinin; and ART500 -diet with 500 ppm of artemisinin. Artemisinin enhanced the productive performances of broiler chickens at the lowest concentration (5 ppm), but at the highest concentration (500 ppm), it negatively affected weight gain and the feed conversion ratio. The performance characteristics of the chickens whose diets were supplemented with 50 ppm artemisinin were similar to those of the control group. Additionally, 5 ppm artemisinin in feed did not significantly affect the haematological parameters of the chickens, but 50 and 500 ppm artemisinin induced a gradual decline of the total leukocytes, lymphopenia, monocytosis, and eosinopenia, and the highest concentration caused anaemia. Artemisinin at a low concentration could be used as a feed additive in the poultry industry to improve organic broiler production performance with no serious side effects.

Exploring the Ameliorating Role of Thymus Vulgaris and Artemisia Annua Powders on the Side Effects of Diclazuril Drug in Eimeria Tenella Experimentally Infected Broiler Chickens

“…This result confirmed with the histopathological finding ofintestine, which revealed normal intestinal villi; this finding was accepted with findings obtained by Wan et al (2017). In contrast the result obtained by Pop et al (2017) who reported higher body weight and average daily intake of food in broilers fed Artemisia diets than in the control group. The differences could be explained by the different climatic conditions under which feeding experiments (hot and humid seasons) were conducted.…”

Artemisia Annua as Phytogenic Feed Additive in the Diet of Broilers (14-35 Days) Reared under Heat Stress (32 ºC)

“…Table 2 data did not show a significant (p>0.05) difference between the three groups regarding the feed conversion ratio. Pop et al (2017) has shown that Ross 308 broiler chicks reared under normal conditions of temperature and treated with 50 ppm artemisinin showed gains and feed conversion ratio comparable with those of the broiler receiving the conventional diet formulation. The different results of these studies may be accounted by the different chemical composition of the used plant, or by the concentrations, active matter and biological activity of the plant (Amad et al 2011).…”

Influence of Artemisia Annua on Broiler Performance and Intestinal Microflora

“…12.88%, and 14.70% lower, respectively, compared to the results of our study, while the expected difference among the two hybrids is about 1.71% (according to Management Guide of Cobb 500 Hybrid and Management Guide of Ross 308 Hybrid). Pop et al (2017) noticed that the use of lower concentrations of artemisinin (5 ppm) in Ross 308 broilers (1-28 days) increased the average daily feed intake, the average daily weight gain and improved the feed conversion ratio, while the higher concentration of artemisinin (500 ppm) caused reduced weight gain, inefficient feed conversion, and a lower feed intake. Several researchers have shown that the essential oils act against Gram-negative bacteria, such as Campylobacter jejuni, Escherichia coli, Mycoplasma gallisepticum, Mycoplasma synoviae, Pseudomonas aeruginosa, Salmonella enteridis, or Klebsiella sp.…”