Influence of Dietary Components on Regulatory T Cells

Issazadeh‐Navikas, Shohreh; Teimer, Roman; Bockermann, Robert

doi:10.2119/molmed.2011.00311

Cited by 78 publications

(61 citation statements)

References 138 publications

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“…IL-10 has inhibitory effects on Th1 cells which produce pro-inflammatory cytokines. 40 To the best of our knowledge, this was the first study in which a particular probiotic capsule was formulated for RA patients. The double-blind and placebo-controlled design of the clinical trial also allowed for unbiased interpretation of the results obtained.…”

Section: Casei 01 Capsules Evaluationmentioning

confidence: 99%

Formulation and Design of Probiotic Supplements for Rheumatoid Arthritis Patients

Vaghef-Mehrabani¹,

Homayouni-Rad²,

Alipour³

et al. 2018

Pharm Sci

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Section: Casei 01 Capsules Evaluationmentioning

confidence: 99%

Formulation and Design of Probiotic Supplements for Rheumatoid Arthritis Patients

Vaghef-Mehrabani¹,

Homayouni-Rad²,

Alipour³

et al. 2018

Pharm Sci

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“…Hence, it would not be surprising to find out that part of side effects associated with long term use of glucocorticoids (e.g in patients with asthma or chronic respiratory diseases) are the consequence of accumulating senescent cells. Additional pharmacological and nutritional compounds that can modulate the function of regulatory T (Treg) cells and myeloid derived suppressor cells (MDSCs) [29,30], could also play a role in suppression of immune surveillance of senescent cells. Unfortunately, there are still no focused studies in this area and the effects of long term administration of immunomodulatory compounds (including natural bioactive compounds and probiotics) in the accumulation of senescent cells are still unknown.…”

Section: Hypothesis On the "Anti-senolytics Hell"mentioning

confidence: 99%

Does the Existence of Senolytic Compounds Underpin that Anti-Senolytics May Exist? A view on the Heaven and Hell of Cellular Senescence

Malavolta¹

2016

F Nutr Reprt

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The discovery of compounds that can selectively target senescent cells (called senolytic compounds) has moved lot of research around this new field of development ofdrugs and nutraceutical compounds. The promises, expectations and innovations in the therapy of age-related pathologies characterized by an increased low grade chronicinflammatory status [which is likely driven in part by the senescence-associated secretoryphenotype (SASP) produced by accumulating senescent cells] are so high that we are tempted to describe this field as a new scientific "Heaven". However, if this Heaven is real, that might seem to suggest that Hell is also real. In this case the term "Hell" refers not only to the potential side-effects of senolytic compounds and to the pro-senescence effects displayed by other compounds, but also to the possibility that real "anti-senolytics" exist. We cannot exclude that among common drugs (in particular those associated with chronic side-effects in elderly) or natural bioactive compounds there are molecules able to promote resistance to apoptosis in senescent cells, or able to depress senescence immunesurveillance thus promoting accumulation of senescent cells. Comparing differential effects of drugs and bioactive compounds in senescent versusnormal cells could ameliorate the development of drugs and nutraceuticals tailored to the needs of elderly people.

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“…A diet rich in omega-3 unsaturated fatty acids, polyphenols and probiotics has been described to influence the development and character of regulatory T lymphocytes, or T regs 52,53 .…”

Section: Low Salt Diet Omega-3 and Probioticsmentioning

confidence: 99%

Modifiable environmental factors in multiple sclerosis

Fragoso

2014

Arq. Neuro-Psiquiatr.

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Potential environmental modifiable factors involved in multiple sclerosis (MS) include low adherence to treatment, smoking, obesity, low levels of liposoluble vitamins A and D, high consumption of salt, and a sedentary lifestyle. Chronic tobacco use, obesity, sedentarism and insufficient levels of these vitamins all contribute to maintenance of a proinflammatory state. It is unlikely that there will be noticeable improvement in the inflammatory condition of MS if stopping smoking, reducing weight, exercising, increasing vitamin levels are done in an isolated and erratic manner. Modification of each and every one of these environmental risk factors is likely to be an important approach in the management of MS. The present review presents the arguments for an association between these hazardous modifiable factors and the chronic inflammatory state observed in MS.Keywords: multiple sclerosis, smoking, obesity, vitamin D, vitamin A, exercise. RESUMOPotenciais fatores ambientais modificáveis envolvidos na esclerose múltipla (EM) incluem baixa adesão ao tratamento, tabagismo, obesidade, baixos níveis das vitaminas lipossolúveis A e D, e um estilo de vida sedentário. O uso crônico de tabaco, obesidade, sedentarismo e níveis insuficientes destas vitaminas podem todos contribuir para a manutenção de um estado pró-inflamatório. É pouco provável que haja melhora notável na condição inflamatória da EM se a cessação do tabagismo, a redução de peso, exercícios e maiores níveis de vitaminas forem obtidos isoladamente e de maneira errática. A modificação de cada um destes fatores de risco ambientais poderá ser importante parte do manejo eficaz da EM. A presente revisão apresenta argumentos para uma associação entre os fatores modificáveis nocivos e o estado inflamatório crônico observado na EM. It is possible that, with a specific approach to modifiable factors, the use of more aggressive treatment may not be necessary and the patient might thrive on immunomodulatory drugs that have less severe side effects. However, when the patient presents an aggressive form of MS and/or does not respond to immunomodulatory drugs 3 , the immediate reaction is to progress to immunosuppression 4 . Perhaps it is time to consider the modifiable factors in MS when treating a patient. It goes without saying that adequate adherence to treatment needs to have been confirmed before the patient is given second-line therapy with potentially more serious, and even fatal, side effects. Through quitting smoking, losing weight, exercising and maintaining proper serum levels of vitamins A and D, the patient may respond better to all pharmacological treatments. It is, after all, the environmental factors that perpetuate the inflammatory state in MS and, for unknown reasons, these factors are frequently ignored. A summary of the potentially modifiable factors in presented in Table. Departamento de Neurologia, Faculdade de Medicina, Universidade Metropolitana de Santos, Santos SP, Brazil. . The relative risk of developing MS among smokers is almost twi...

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Influence of Dietary Components on Regulatory T Cells

Cited by 78 publications

References 138 publications

Formulation and Design of Probiotic Supplements for Rheumatoid Arthritis Patients

Formulation and Design of Probiotic Supplements for Rheumatoid Arthritis Patients

Does the Existence of Senolytic Compounds Underpin that Anti-Senolytics May Exist? A view on the Heaven and Hell of Cellular Senescence

Modifiable environmental factors in multiple sclerosis

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