2004
DOI: 10.1038/sj.jhh.1001784
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Influence of dietary sodium on the renin–angiotensin–aldosterone system and prevalence of left ventricular hypertrophy by EKG criteria

Abstract: We investigated the interplay of dietary sodium and renin-angiotensin-aldosterone system (RAAS) activity with the prevalence of left ventricular hypertrophy (LVH) in essential hypertension. Electrocardiograms (EKG) were reviewed for the presence of LVH in 160 hypertensive patients. We then compared the rate of LVH to levels of plasma renin activity (PRA) and serum aldosterone under high and low sodium diet conditions. On high sodium diet, serum aldosterone was significantly higher (7.770.93 vs 5.770.35 ng/dl, … Show more

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Cited by 18 publications
(18 citation statements)
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“…Details of this protocol have been described previously (4,24,25). In brief, to control for the influence of medications on components of the RAAS, all angiotensin-converting enzyme inhibitors (ACEI), angiotensin receptor blockers, or mineralocorticoid receptor antagonists were discontinued for 3 months and ␤-blockers and diuretics were discontinued for 1 month before the study.…”
Section: Protocolmentioning
confidence: 99%
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“…Details of this protocol have been described previously (4,24,25). In brief, to control for the influence of medications on components of the RAAS, all angiotensin-converting enzyme inhibitors (ACEI), angiotensin receptor blockers, or mineralocorticoid receptor antagonists were discontinued for 3 months and ␤-blockers and diuretics were discontinued for 1 month before the study.…”
Section: Protocolmentioning
confidence: 99%
“…alt sensitivity of blood pressure occurs frequently in individuals with type 2 diabetes mellitus (T2DM) and is associated with an increased risk for left ventricular hypertrophy (LVH), renal disease, and cardiovascular death (1)(2)(3)(4). The underlying cause of salt sensitivity in individuals with T2DM is unknown.…”
mentioning
confidence: 99%
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“…These data were not compatible with mineralocorticoid insufficiency, and it can be explained by hypoalbuminemia, which is common in these PCM patients 18 , or different level of dietary sodium 22 , which was not controlled in this study. The relationship between hypoalbuminemia and cases with more severity and/or more time of disease was also not established in these cases.…”
Section: Discussionmentioning
confidence: 57%
“…Angiotensin II also improves coronary artery permeability, thereby permitting growth factors to diffuse into the myocardium [12]. Excess sodium independent of volume overload can also lead to cardiac hypertrophy, and this appears to be mediated by excess aldosterone [13] as the use of an aldosterone antagonist can ameliorate the cardiac hypertrophy [14]. All of these will increase cardiac stiffness and promote diastolic dysfunction.…”
mentioning
confidence: 99%