Influence of Different Antidepressant Drugs on the Effect of Chronic Variable Stress on Restraint-Induced Dopamine Release in Frontal Cortex

Cuadra, Gabriel; Zurita, Alejandra; Gioino, Gabriela; Molina, Vı́ctor A.

doi:10.1016/s0893-133x(01)00234-2

Cited by 30 publications

(22 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The fact that both baseline and stress-induced cortisol levels correlated with AMPH-induced DA release suggests that ambient cortisol concentrations over time may influence or sensitize mesolimbic dopaminergic transmission. Supporting this idea are preclinical studies showing that both stress and glucocorticoids can enhance mesolimbic DA responses (Piazza et al, 1996;Cadoni et al, 2003;Saal et al, 2003;Barrot et al, 2000;Cho and Little, 1999;Cuadra et al, 2001;Piazza and Le, 1998;Marinelli et al, 1994;Cador et al, 1993). Taken together results from our study and the preclinical findings suggest that high cortisol secretors are high DA releasers and experience greater subjective effects from psychostimulants than low cortisol secretors.…”

Section: Discussionsupporting

confidence: 80%

“…Stress-induced LTP can be blocked with a glucocorticoid receptor (GR) antagonist (Saal et al, 2003). Using microdialysis techniques, investigators have shown that an array of stress paradigms increases mesocorticolimbic DA activity and that these effects are accompanied by behavioral manifestations (Cadoni et al, 2003;Cuadra et al, 2001). Glucocorticoid administration facilitates the psychomotor stimulant effects of cocaine (Marinelli et al, 1994;Cador et al, 1993) and morphine (Marinelli et al, 1994) in rodents.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Association of Amphetamine-Induced Striatal Dopamine Release and Cortisol Responses to Psychological Stress

Wand

Oswald

McCaul

et al. 2007

Neuropsychopharmacol

148

View full text Add to dashboard Cite

Preclinical studies have shown that stress and glucocorticoids increase mesolimbic dopamine (DA) and thereby facilitate psychostimulant self-administration. The relationship between stress-induced cortisol and mesolimbic DA responses to psychostimulants has not been studied in humans. To test the hypotheses that glucocorticoid responses to psychological stress are correlated with DA and subjective responses to psychostimulants in humans, 25 healthy adults (18-29 years) completed the Trier Social Stress Test (TSST) and two positron emission tomography (PET) scans with high-specific [ 11 C]raclopride. The first scan was preceded by intravenous saline and the second by amphetamine (AMPH). Findings showed that stress-induced cortisol levels were positively associated with AMPH-induced DA release in the ventral striatum and other striatal regions. Subjects with higher cortisol responses to stress also reported more positive subjective drug effects with AMPH than subjects with lower responses. The results are consistent with preclinical findings showing an interrelationship between glucocorticoids and mesolimbic DA dynamics, which may influence psychostimulant self-administration in humans.

show abstract

Section: Discussionsupporting

confidence: 80%

Section: Introductionmentioning

confidence: 99%

Association of Amphetamine-Induced Striatal Dopamine Release and Cortisol Responses to Psychological Stress

Wand

Oswald

McCaul

et al. 2007

Neuropsychopharmacol

148

View full text Add to dashboard Cite

show abstract

“…Rats exposed to 7 days of unpredictable stress and tested 7 days later in the elevated plus-maze or a novel environment showed increased anxiety-like behaviors [13]. Single or multiple experiences of exposure to a predator, predator odor or social defeat augmented anxiogenic responses in rodents when tested 1 to 21 days following the exposure episode [1,2,4,5,7,8,11,45].…”

Section: Discussionmentioning

confidence: 93%

“…The stressful stimulus may be necessary to potentiate passive and active anxiety-like behaviors in rats exposed previously to chronic stress, as seen with other behavioral or neurochemical responses [e.g. 13,23,26,38,39,48].…”

Section: Discussionmentioning

confidence: 99%

The delayed effects of chronic unpredictable stress on anxiety measures

Matuszewich

Karney

Carter

et al. 2007

Physiology & Behavior

View full text Add to dashboard Cite

Previous research has found that exposure to unpredictable stress can augment anxiety in humans and animals. The appearance of anxiety symptoms in humans frequently develop after stress exposure has terminated, but few rodent studies have systematically examined the delayed anxiogenic effects of unpredictable stress. Therefore, the current study investigated whether anxiety-like behaviors in rats would increase at several time intervals following exposure to chronic unpredictable stress (CUS). Unconditioned and conditioned response tasks were used to assess anxiety in male rats 1, 7 or 14 days following exposure to 10 days of a variety of stressors. Rats exposed to CUS showed increased burying behaviors and immobility during the defensive burying test, a conditioned anxiety test. The effects on burying behavior were apparent 7 and 14 days after the termination of the unpredictable stress procedure, but not when tested 1 day after CUS. Total time immobile in the defensive burying test also increased 14 days after termination of the last stressor. In contrast, there were no significant effects of CUS on behavioral measures in the unconditioned response tasks, the elevated plus-maze or light-dark box, at any time point following exposure to CUS. The current findings suggest that CUS may be a useful model of human conditioned anxiety that develops subsequent to chronic stress exposure.

show abstract

“…In contrast to the findings for cortisol, a general lack of relationship was observed between AMPH-induced GH and subjective drug responses or DA release, suggesting that the findings were specific to cortisol and cannot be generalized to all 'stress' hormones. Findings from in vivo microdialysis studies indicate that a variety of laboratory stressors increase mesocorticolimbic DA activity in animals (Cadoni et al, 2003;Cuadra et al, 2001;Piazza and Le Moal, 1998;Tidey and Miczek, 1996). Stress has been reported to cross-sensitize to both psychostimulants (Kosten et al, 2003;Sorg, 1992) and alcohol (Yavich and Tiihonen, 2000), leading to greater increases in striatal DA concentrations following drug administration.…”

Section: Discussionmentioning

confidence: 99%

Relationships Among Ventral Striatal Dopamine Release, Cortisol Secretion, and Subjective Responses to Amphetamine

Oswald

Wong

McCaul

et al. 2005

Neuropsychopharmacol

296

166

View full text Add to dashboard Cite

There is evidence that stress and glucocorticoids alter drug self-administration and mesolimbic dopamine (DA) activity in preclinical models. The primary purpose of this study was to test the hypothesis that glucocorticoids are associated with psychostimulant reinforcement and DA release in humans. In total, 16 healthy adults, ages 18-27 years, underwent two consecutive 90-min PET studies with high specific activity [11 C]raclopride. The first scan was preceded by intravenous saline, and the second by intravenous amphetamine (AMPH 0.3 mg/kg). DA release was defined as the percent change in raclopride binding between the placebo and AMPH scans. Measures of subjective drug effects, plasma cortisol, and growth hormone (GH) were obtained. Findings showed that cortisol levels were positively associated with AMPH-induced DA release in the left ventral striatum (LVS) and the dorsal putamen. Subjects with higher cortisol responses to AMPH also reported more positive subjective drug effects than subjects with lower cortisol responses; no association was observed between cortisol levels and negative drug effects. Higher ratings of positive drug effects were also associated with greater DA release in the LVS, dorsal putamen, and dorsal caudate. A general lack of relationship was observed between GH responses to AMPH and DA release or subjective drug responses. Our findings provide evidence of interrelationships between glucocorticoid levels, subjective responses to IV AMPH, and brain DA release in humans. The results are consistent with those of preclinical studies, suggesting that individual differences in HPA axis function may influence vulnerability to alcohol and drug dependence in humans.

show abstract

Influence of Different Antidepressant Drugs on the Effect of Chronic Variable Stress on Restraint-Induced Dopamine Release in Frontal Cortex

Cited by 30 publications

References 37 publications

Association of Amphetamine-Induced Striatal Dopamine Release and Cortisol Responses to Psychological Stress

Association of Amphetamine-Induced Striatal Dopamine Release and Cortisol Responses to Psychological Stress

The delayed effects of chronic unpredictable stress on anxiety measures

Relationships Among Ventral Striatal Dopamine Release, Cortisol Secretion, and Subjective Responses to Amphetamine

Contact Info

Product

Resources

About