The intelligent design of lightweight, protective systems requires the use of numerical simulations widely to weed unsuccessful tests and minimise the number of expensive experiments. At the same time, it is necessary to have verified numerical models of all materials that are used in a protective structure to obtain adequate numerical simulation results. In this research, the impact performance of the ceramic-faced mosaic panel against the impactor with a complicated structure was studied using numerical simulations in thу commercially available package LS-DYNA. Backing types being considered were Aluminium AA 5083 and Dyneema ® HB80 UD composite. A new mesoscale model of 99.5% alumina based on the bonded particle method was calibrated and verified through the comparison with the known experimental data. Further, designs with different configurations of mosaic ceramic layers having hex tiles were studied and compared. The results indicated that even small lateral gaps between ceramic tiles decreased the overall panel performance regardless of both the impact site and a backing type. At the same time, the presence of gaps reduces damages of the ceramic layer and can change the impactor trajectory that can be used in multi-layered structures with distant layers. Thus, it is necessary to find a balance between survivability and mass efficiency for each protective structure.