Influence of different durations of estrogen deficiency on alveolar bone loss in rats

Amadei, Susana Ungaro; Souza, Daniela Martins de; Brandão, Adriana Aigotti Haberbeck; Rocha, Rosilene Fernandes da

doi:10.1590/s1806-83242011000600011

Cited by 19 publications

(20 citation statements)

References 26 publications

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“…However, more recent studies on humans have shown no relation between periodontal disease and alcohol consumption [6][7] . The use of rat models has been applied in the evaluation of periodontal pathogenesis 8 and regarding the influence of risk indicator/factors, such as estrogen deficiency [9][10] , alcohol consumption [11][12][13][14][15][16] , nicotine 17 and simultaneous nicotine and alcohol use 18 on disease progression.…”

Section: Introductionmentioning

confidence: 99%

Effects of alcohol intake in periodontitis progression in female rats: a histometric study

Souza¹,

Ricardo²,

Rocha³

2014

Braz. J. Oral Sci.

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Aim: To evaluate histometrically the effect of low and high caloric value of ethanol on ligatureinduced bone loss in female rats. Methods: Sixty female rats were divided into five groups of 12 animals each: Normal Control (water), Test A (low ethanol), Control A (low iso), Test B (high ethanol) and Control B (high iso). Control Groups A and B received diets with the same amount of calories consumed by Test Groups A and B, respectively, with ethanol replaced by isocaloric amounts of carbohydrate. Four weeks prior to the end of the experimental period, half of the rats in each group were randomly assigned to receive a ligature on mandibular molar, whereas the other half of group was left unligated. At 8 weeks, the animals were sacrificed, and the specimens were processed to obtain decalcified sections. The area of periodontal ligament and/or bone loss in the furcation region of the first molars was histometrically measured in five sections per specimen (mm²). Results: Ethanol intake did not have effect on the alveolar bone loss in unligated teeth (p>0.05). However, in ligature-induced periodontitis, high value of calories associated with ethanol feeding enhanced the area of bone loss (p<0.05). Conclusions: The results of this study demonstrated that a low-ethanol diet did not affect the periodontium, while a high-ethanol diet may aggravate the progression of periodontitis, as demonstrated by the increased furcation region bone destruction in periodontal disease.

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Section: Introductionmentioning

confidence: 99%

Effects of alcohol intake in periodontitis progression in female rats: a histometric study

Souza¹,

Ricardo²,

Rocha³

2014

Braz. J. Oral Sci.

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“…It has been suggested that estrogen deficiency may be a risk factor for tooth loss [3,13,24,25], might affect dental implant success or compromise osseous support in totally edentulous subjects, leading to difficulty in wearing dentures. However the contribution of osteoporosis to tooth loss is difficult to demonstrate because teeth can be lost for several reasons other than the loss of bone support [26]. The wide divergence in the literature may be related to several factors such as the sample used, the method of analysis, the region, nutritional status, the time of analysis and the association with other drugs [2,14,18,[26][27][28][29][30].…”

Section: Discussionmentioning

confidence: 99%

“…However the contribution of osteoporosis to tooth loss is difficult to demonstrate because teeth can be lost for several reasons other than the loss of bone support [26]. The wide divergence in the literature may be related to several factors such as the sample used, the method of analysis, the region, nutritional status, the time of analysis and the association with other drugs [2,14,18,[26][27][28][29][30].…”

Section: Discussionmentioning

confidence: 99%

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Estrogen treatment and periodontal disease progression: an experimental study in ovariectomized rats

Spalding

Amschilnger

Prado

et al. 2012

BDS

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The aim of this study was to investigate different periods of estrogen replacement therapy onset on the progression of experimental periodontitis in ovariectomized rats. divided into two groups, experimental and control that received 17ß estradiol or vehicle, respectively. Each treatment immediately, one, two, three and four weeks after the ovariectomy. A month after ovariectomy, a cotton ligature was placed around the maxillary second microscopic and histometric aspects of the periodontal area were analyzed. The results indicated that estrogenresorption of alveolar bone adjacent to the maxillary second molar roots, once no differences between test and control groups were detected. Under the conditions of this experiment, estrogen replacement therapy did not delay the progression of induced periodontitis. KEYWORDSEstradiol; Osteoporosis; Ovariectomy; Periodontal diseases. Estrogen treatment and periodontal disease progression: an experimental study in ovariectomized rats RESUMOO objetivo deste estudo foi investigar a ação da terapia de reposição de estrógeno iniciada em diferentes períodos na progressão da periodontite induzida em ratas ovariectomizadas. Sessenta e cinco ratas Wistar foram ovariectomizadas e divididas em dois grupos, experimental e controle, os quais receberam 17β estradiol ou veículo, respectivamente. Cada grupo foi subdividido em cinco subgrupos, os quais iniciaram o tratamento imediatamente, uma, duas, três e quatro semanas após a ovariectomia. Um dos segundos molares superiores. Trinta e cinco dias após microscópicos e histomorfométricos da região periodontal. estrógeno não possui efeito direto sobre a reabsorção do osso alveolar adjacente às raízes dos segundo molares, uma vez que não houve diferença entre os grupos experimental e controle. Dentro das limitações deste estudo concluiuse que a terapia de reposição de estrógeno não retardou a progressão da periodontite induzida.

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“…Changes in periodontal conditions are associated with variations in the levels of these substances 1 . In this respect, the use of oral contraceptives plays an important role 2 , as these drugs modify the estrous cycle to prevent pregnancy.…”

Section: Introductionmentioning

confidence: 99%

Chronic stress associated to contraceptives use on the progression of ligature-induced periodontitis in rats

Martins

Semenoff

Borges

et al. 2016

Rev. odontol. UNESP

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ResumoIntrodução: Os contraceptivos são amplamente utilizados pelas mulheres em grande parte do mundo. O estresse associado a sua utilização pode conduzir respostas adversas no organismo. Objetivo: O objetivo deste trabalho foi avaliar os efeitos do estresse crônico associado ou não com o uso de contraceptivos na progressão de periodontite induzida por ligadura em ratas Lewis. Material e método: Para tanto, quarenta ratas foram divididas aleatoriamente em 5 grupos (n = 8): Grupo Contraceptivo e Ligadura (CG); Grupo Estresse e Ligadura (SG); Grupo Contraceptivo, Estresse e Ligadura (CSG); Grupo Ligadura (LG); e Grupo Controle (CtrlG). Um contraceptivo injetável foi administrado nos grupos CG e CSG no início do experimento. No dia seguinte, a periodontite foi induzida nos grupos CG, SG, LG e CSG, através da colocação de ligaduras no segundo molar superior direito destes animais. No terceiro dia, o SG e o CSG foram submetidos a um modelo de estresse crônico usando contenção física e exposição ao frio. Após 60 dias, os animais foram sacrificados e submetidos a medidas histométricas. Foram considerados dois parâmetros: perda de inserção histológico (CEJ-PL) e perda óssea (CEJ-BC). Resultado: Os resultados indicaram que o CtrlG (CEJ-PL 0,10 ± 0,00; CEJ-BC 0,34 ± 0,02) apresentaram os valores mais baixos (p<0,05). O grupo SG (CEJ-PL 0,90 ± 0,24; CEJ-BC 1,30 ± 0,28) apresentou valores mais elevados que foram significativamente diferentes (p<0,05) dos resultados do LG. Os outros grupos apresentaram resultados estatísticos semelhantes (p>0,05). Conclusão: Os resultados deste estudo não permitem uma avaliação da susceptibilidade dos animais à periodontite induzida por ligadura. Sendo necessários, portanto, outros estudos que elucidem melhor a questão.Descritores: Periodontite; anticoncepcionais; ratos; estresse. AbstractIntroduction: Contraceptives are widely used by women in much of the world. The stress associated with their use can lead adverse responses in the body. Objective: The aim of this paper was to evaluate the effects of chronic stress associated with contraceptive use on the progression of ligature-induced periodontitis in female Lewis rats. Material and method: Therefore, forty rats were randomly divided into 5 groups (n = 8): contraceptive and ligature group (CG); stress and ligature group (SG); contraceptive, stress and ligature group (CSG); ligature group (LG); and control group (CtrlG). An injectable contraceptive was administered to the CG and CSG groups at the beginning of the experiment. On the following day, periodontitis was induced in the CG, SG, LG and CSG groups by placing ligatures on the upper-right second molar. On the third day, the SG and the CSG were subjected to a chronic stress model using physical restraint and cold exposure. After 60 days, the animals were euthanized and submitted to histometric measurements. Two parameters were considered: histological attachment loss (CEJ-PL) and bone loss (CEJ-BC). Regarding CEJ-PL/CEJ-BC. Result: The results indicated that the CtrlG (CEJ-PL 0.10 ± 0....

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Influence of different durations of estrogen deficiency on alveolar bone loss in rats

Cited by 19 publications

References 26 publications

Effects of alcohol intake in periodontitis progression in female rats: a histometric study

Effects of alcohol intake in periodontitis progression in female rats: a histometric study

Estrogen treatment and periodontal disease progression: an experimental study in ovariectomized rats

Chronic stress associated to contraceptives use on the progression of ligature-induced periodontitis in rats

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