Influence of different electrolytes and oils on the stability of W1/O/W2 double emulsion during storage and in vitro digestion

Lee, Jiseon; Kwak, Eunji; Kim, Dong-Won; Jo, Yeon‐Ji; Choi, Mi‐Jung

doi:10.1007/s10068-023-01282-5

Cited by 8 publications

(2 citation statements)

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“…The authors argued that the gelling behaviour of gelatine coupled with NaCl interaction with PGPR could have reduced the Laplace pressure and increased surfactant packing-allowing for a stable emulsion-at least for the length of the study, 1 month. Lee et al (2023) presented NaCl and low inner droplet fraction as a successful strategy to stabilize double emulsions for long-term applications [109]. However, osmotic pressure induced by these electrolytes also plays a major role in stabilizing the emulsions.…”

Section: (B) Enhanced Stabilitymentioning

confidence: 99%

“…This review clearly presented all the four challenges in detail under Section 4 . Complex emulsions with 50% or lesser inner droplet volume to overall emulsion volume are more stable; using NaCl and MgCl 2 as electrolytes can also ensure excellent surfactant packing, thus avoiding leakage of the actives [ 108 , 109 ]. Furthermore, maintaining the osmotic pressure across the emulsion is highly desirable to prevent coalescence and associated drug–drug interactions and emulsion destabilization [ 37 , 91 ].…”

Section: Future Directions and Conclusionmentioning

confidence: 99%

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Complex Emulsions as an Innovative Pharmaceutical Dosage form in Addressing the Issues of Multi-Drug Therapy and Polypharmacy Challenges

Yandrapalli

2024

Pharmaceutics

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This review explores the intersection of microfluidic technology and complex emulsion development as a promising solution to the challenges of formulations in multi-drug therapy (MDT) and polypharmacy. The convergence of microfluidic technology and complex emulsion fabrication could herald a transformative era in multi-drug delivery systems, directly confronting the prevalent challenges of polypharmacy. Microfluidics, with its unparalleled precision in droplet formation, empowers the encapsulation of multiple drugs within singular emulsion particles. The ability to engineer emulsions with tailored properties—such as size, composition, and release kinetics—enables the creation of highly efficient drug delivery vehicles. Thus, this innovative approach not only simplifies medication regimens by significantly reducing the number of necessary doses but also minimizes the pill burden and associated treatment termination—issues associated with polypharmacy. It is important to bring forth the opportunities and challenges of this synergy between microfluidic-driven complex emulsions and multi-drug therapy poses. Together, they not only offer a sophisticated method for addressing the intricacies of delivering multiple drugs but also align with broader healthcare objectives of enhancing treatment outcomes, patient safety, and quality of life, underscoring the importance of dosage form innovations in tackling the multifaceted challenges of modern pharmacotherapy.

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Section: (B) Enhanced Stabilitymentioning

confidence: 99%