Influence of different menstrual phases on the Bispectral Index during dexmedetomidine sedation

Han, Chao; Ge, Shengxiang; Huang, Shaoqiang; Lu, Yaojun; Li, Ning

doi:10.1016/j.kjms.2016.09.001

Cited by 7 publications

(7 citation statements)

References 29 publications

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“… 15 , 16 Furthermore, dexmedetomidine is a new type of α2-adrenergic receptor agonist with the effects of sedation, stress inhibition, and reduction of sympathetic activity. 18 Nevertheless, it has a great negative impact on cardiopulmonary circulation, with a higher risk of inducing hypotension and bradycardia in the patient. 17 , 19 Acting as analgesics and sedatives with different mechanisms, oxycodone hydrochloride and dexmedetomidine may act on different sites of pain reflex arc respectively, and thus exert a synergistic effect under a combined usage.…”

Section: Discussionmentioning

confidence: 99%

Effect of Oxycodone hydrochloride combined with Dexmedetomidine on quality of recovery and stress response after general anesthesia in patients who had Laparoscopic Cholecystectomy

Wang¹,

Wu²,

Liu

et al. 2021

Pak J Med Sci

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Objective: To explore the effect of oxycodone hydrochloride combined with dexmedetomidine on the recovery quality and stress response during anesthesia in patients undergoing laparoscopic cholecystectomy (LC). Methods: Ninety patients who had LC in Cangzhou Hospital of Integrated TCM-WM of Hebei from December 2016 to December 2019 were selected and divided into dexmedetomidine group (DEX group), oxycodone hydrochloride group (Q group), dexmedetomidine + oxycodone hydrochloride group (DQ group) by a random number table method, with 30 cases in each group. At the time before anesthesia induction (T0), and immediately (T1), 1 min (T2), 10 min (T3) and 30 minutes (T4) after extubation, the general vital signs of three groups were observed, and plasma cortisol (COR), epinephrine (E), norepinephrine (NE) and blood glucose (GLU) were measured. The spontaneous respiration recovery time, wake-up time, VAS score of each time period after extubation, extubation quality score, and adverse event rate were recorded. Results: The vital signs at each time point of extubation, recovery time of spontaneous respiration, wake-up time, and extubation quality of DQ group were better than those of DEX group and Q group (P<0.05). The incidence of agitation, VAS score at T2 and T3, plasma concentrations of Cor, E, NE and Glu at T1, T3 and T4 in DQ group were significantly lower than those in Q group and DEX group (P<0.05). Conclusion: Oxycodone hydrochloride combined with dexmedetomidine can improve the recovery quality and reduce stress response in patients with LC after anesthesia, and can be safely used in patients with LC. doi: https://doi.org/10.12669/pjms.37.5.3959 How to cite this:Wang G, Wu Q, Liu W, Jing Y. Effect of Oxycodone hydrochloride combined with Dexmedetomidine on quality of recovery and stress response after general anesthesia in patients who had Laparoscopic Cholecystectomy. Pak J Med Sci. 2021;37(5):---------. doi: https://doi.org/10.12669/pjms.37.5.3959 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Section: Discussionmentioning

confidence: 99%

Effect of Oxycodone hydrochloride combined with Dexmedetomidine on quality of recovery and stress response after general anesthesia in patients who had Laparoscopic Cholecystectomy

Wang¹,

Wu²,

Liu

et al. 2021

Pak J Med Sci

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“…The sedative effect of dexmedetomidine has been shown to be more significant in female patients during the luteal phase of menstrual cycles than the follicular phase [ 23 ]. Progesterone and its metabolites are known to have sedative, anxiolytic, analgesic and anticonvulsant effects [ 24 – 26 ].…”

Section: Discussionmentioning

confidence: 99%

Propofol-sparing effect of different concentrations of dexmedetomidine

Xiong

Zheng

et al. 2018

Anaesthesist

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BackgroundThe pharmacodynamics of propofol are closely linked to gender. Dexmedetomidine can decrease propofol needs during propofol anesthesia. The aim of this study was to compare the gender differences on the calculated effect site median effective concentration (EC50) of propofol for loss of consciousness (LOC) after pretreatment with different concentrations of dexmedetomidine.MethodsIn this study 60 male and 60 female patients were randomly allocated to receive dexmedetomidine at target plasma concentrations of 0.0 ng/ml (0.0 group), 0.4 ng/ml (0.4 group), 0.6 ng/ml (0.6 group) and 0.8 ng/ml (0.8 group). Propofol was administered after dexmedetomidine had been intravenously infused for 15 min. The propofol infusion was targeted to provide an initial effect-site concentration of 1.0 μg/ml, followed by increments by 0.2 μg/ml when the effect-site concentration and target concentration of propofol were in equilibrium until LOC was established, where LOC was defined by the observer’s assessment of alertness/sedation scale (OAA/S) score < 2.ResultsThe calculated effect-site EC50 of propofol LOC was higher in males than in females in the 0.0, 0.4, 0.6, and 0.8 groups (2.43 vs. 2.17, 1.99 vs. 1.82, 1.72 vs. 1.56 and 1.50 vs. 1.32 μg/ml, respectively, all p < 0.05). The hypnotic interaction between dexmedetomidine and propofol could be described with an additive model of pharmacodynamic interaction.ConclusionGender significantly influenced the calculated effect-site EC50 of propofol for LOC after pretreatment with different concentrations of intravenous dexmedetomidine. It was concluded that an additive interaction could describe the results seen. Thus, gender has to be considered when these drugs are co-administered.

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“…Only four studies have tried to directly study the influence of the phase of the menstrual cycle on anaesthetic requirement [ Table 2 ]. [ 43 46 47 48 ] Erden et al . found a decreased sevoflurane requirement in the LP compared to the FP.…”

Section: Research Studies On the Influence Of Various Menstrual Cyclementioning

confidence: 99%

“…Thus, the sedative effect of dexmedetomidine was more significant during the LP than during the FP. [ 48 ] Hoshino et al . found in a study that the passive collapsibility of the upper airway was higher in the mid-LP than in the FP during propofol anaesthesia.…”

Section: Research Studies On the Influence Of Various Menstrual Cyclementioning

confidence: 99%

Does the phase of the menstrual cycle really matter to anaesthesia?

Kurdi

Ramaswamy

2018

Indian J Anaesth

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The menstrual cycle is a physiological phenomenon that is accompanied by several hormonal fluctuations involving oestrogen and progesterone. Oestrogen and progesterone exert several physiological effects. There are many questions pertaining to the influence of the physiology of menstruation on anaesthesia. We attempted to find out whether the phase of the menstrual cycle can alter the physiological functions during anaesthesia, the perioperative management and outcomes. We performed a literature search in Google Scholar, PubMed and Cochrane databases for original and reviewed articles on the phases of the menstrual cycle and their relation to anaesthesia-related physiological parameters to find an answer to these questions. Many studies have shown that women, perimenstrually, may have increased pain perception, exacerbation of systemic diseases, vocal cord/peripheral oedema and post-operative nausea and vomiting (PONV). Some of the other notable findings in most studies were sleep disturbances in the luteal phase (LP), increased occurrence of PONV in the ovulatory phase and a lower requirement of intravenous sedative and anaesthetic drug requirements in the LP. We found contradictory results concerning pain perception and PONV in relation to the follicular and LPs. However, we found that literature regarding the phase of the menstrual cycle and the haemodynamic response to intubation, anaesthesia-induced hypnosis and perioperative blood loss is relatively scarce. Thus, there is a need to conduct good quality research on these topics.

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Influence of different menstrual phases on the Bispectral Index during dexmedetomidine sedation

Cited by 7 publications

References 29 publications

Effect of Oxycodone hydrochloride combined with Dexmedetomidine on quality of recovery and stress response after general anesthesia in patients who had Laparoscopic Cholecystectomy

Effect of Oxycodone hydrochloride combined with Dexmedetomidine on quality of recovery and stress response after general anesthesia in patients who had Laparoscopic Cholecystectomy

Propofol-sparing effect of different concentrations of dexmedetomidine

Does the phase of the menstrual cycle really matter to anaesthesia?

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