Influence of different modes of exercise training on inflammatory markers in older adults with and without chronic diseases: A systematic review and meta-analysis

Khalafi, Mousa; Akbari, Amir; Symonds, Michael; Pourvaghar, Mohammad Javad; Rosenkranz, Sara K.; Tabari, Elma

doi:10.1016/j.cyto.2023.156303

Cited by 11 publications

(4 citation statements)

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“…( 58 ) found that the 12-week RT program had a beneficial effect on reducing metabolic syndrome and CRP levels in older women. According to the meta-analysis, physical exercise can significantly reduce CRP levels in older individuals, regardless of the type of physical activity ( 48 , 49 , 59 ). Another meta-analysis focusing on patients with type 2 diabetes mellitus demonstrated that exercise effectively reduces CRP levels ( 60 ).…”

Section: Discussionmentioning

confidence: 99%

Effectiveness of resistance training in modulating inflammatory biomarkers among Asian patients with sarcopenia: a systematic review and meta-analysis of randomized controlled trials

Xue,

Han,

Zheng

et al. 2024

Front. Immunol.

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ObjectiveGiven the high incidence of sarcopenia among Asians, it is imperative to identify appropriate intervention methods. The International Clinical Practice Guidelines for Sarcopenia, developed by the International Conference on Sarcopenia and Frailty Research (ICFSR) task force, recommends resistance training (RT) as a primary treatment for managing sarcopenia. Inflammatory biomarkers serve as indicators of sarcopenia. However, there is currently insufficient conclusive evidence regarding the effectiveness of RT in modulating inflammatory biomarker levels among Asian participants with sarcopenia.Data sourcesFour databases were utilized for this study until October 9, 2023. This study focused on randomized controlled trials (RCTs) that examined the effects of RT on interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), C-reactive protein (CRP), and interleukin-10 (IL-10) about sarcopenia. This study has been registered in the PROSPERO database (CRD42024501855).ResultsThe meta-analysis included six studies from Asians involving 278 participants. The results showed a significant decrease in RT for IL-6 (weighted mean difference (WMD) = -0.73, 95% confidence interval (CI) = -1.02 to -0.44; n=5). However, no significant differences were found for TNF-α (WMD = -1.00, 95% CI = -2.47 to 0.46; n=5), CRP (WMD = -0.45, 95% CI = -1.14 to 0.23; n=3), and IL-10 (WMD = 0.13, 95% CI = -3.99 to 4.25; n=2). Subgroup analysis revealed that factors including gender selection, intervention methods, frequency, period, and duration could have a particular effect on the part of inflammatory biomarkers.ConclusionRT has been shown to reduce part of the level of inflammatory markers, specifically IL-6, in Asian sarcopenia participants. However, other inflammatory factors, such as TNF-α, CRP, and IL-10, did not show significant changes. Further research should confirm the impact of RT on these indicators and explore the potential effects of various factors on different inflammatory markers, such as diet, body composition, and medications.Systematic Review Registrationhttps://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=501855, identifier CRD42024501855.

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Section: Discussionmentioning

confidence: 99%

Effectiveness of resistance training in modulating inflammatory biomarkers among Asian patients with sarcopenia: a systematic review and meta-analysis of randomized controlled trials

Xue,

Han,

Zheng

et al. 2024

Front. Immunol.

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“…A recent systematic review and meta‐analysis has demonstrated that exercise training in older adults, especially those with chronic disease, has a small to moderate effect on inflammatory biomarkers by producing a less inflammatory environment (Khalafi et al., 2023). Further research discovered that lifelong endurance training alleviated MCP‐1 and telomeric repeat‐containing RNA (TERRA) accumulation in skeletal muscle biopsies thus suggesting an alteration of one inflammatory biomarker and a biomarker that may delay cellular senescence, respectively (Balan et al., 2021).…”

Section: Inflammatory Response In Old Adult Skeletal Musclementioning

confidence: 99%

Inflammatory pathway communication with skeletal muscle—Does aging play a role? A topical review of the current evidence

Cornish,

Cordingley

2024

Physiological Reports

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Skeletal muscle plays an integral role in locomotion, but also as part of the integrative physiological system. Recent progress has identified crosstalk between skeletal muscle and various physiological systems, including the immune system. Both the musculoskeletal and immune systems are impacted by aging. Increased age is associated with decreased muscle mass and function, while the immune system undergoes “inflammaging” and immunosenescence. Exercise is identified as a preventative medicine that can mitigate loss of function for both systems. This review summarizes: (1) the inflammatory pathways active in skeletal muscle; and (2) the inflammatory and skeletal muscle response to unaccustomed exercise in younger and older adults. Compared to younger adults, it appears older individuals have a muted pro‐inflammatory response and elevated anti‐inflammatory response to exercise. This important difference could contribute to decreased regeneration and recovery following unaccustomed exercise in older adults, as well as in chronic disease. The current research provides specific information on the role inflammation plays in altering skeletal muscle form and function, and adaptation to exercise; however, the pursuit of more knowledge in this area will delineate specific interventions that may enhance skeletal muscle recovery and promote resiliency in this tissue particularly with aging.

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“…On the one hand, older adults with higher levels of circulating inflammatory markers and lower levels of neurotrophic factors have been found to have a higher risk of cognitive decline and the development of neurodegenerative diseases [ 16 – 18 ]. On the other hand, there is a considerable body of literature showing that physical activity can reduce the expression of pro-inflammatory markers, such as interleukin-6 (IL-6) and kynurenine (KYN), and increase levels of neurotrophic factors, such as insulin-like growth factor-1 (IGF-1) in both cognitively intact older adults and older individuals with neurodegenerative disease conditions [ 19 – 21 ].…”

Section: Introductionmentioning

confidence: 99%

Resistance training's impact on blood biomarkers and cognitive function in older adults with low and high risk of mild cognitive impairment: a randomized controlled trial

Vints,

Gökçe,

Šeikinaitė

et al. 2024

Eur Rev Aging Phys Act

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Background The aging brain exhibits a neuroinflammatory state, driven partly by peripheral pro-inflammatory stimuli, that accelerates cognitive deterioration. A growing body of evidence clearly indicates that physical exercise partly alleviates neuroinflammation and positively affects the aging process and cognition. In this randomized controlled trial, we aimed to observe the effect of 12 weeks of resistance training (RT) on peripheral biomarker levels, cognitive function changes and their interrelationship, and explore differences in those exercise-induced changes in older adults with high risk of mild cognitive impairment (MCI) compared to older adults with low risk of MCI. Methods Fifty-two participants (aged 60–85 years old, 28 female) were randomly allocated to a 12 week lower limb RT program consisting of two training sessions per week or waiting list control group. The Montreal Cognitive Assessment (MoCA) was used to stratify participants screened as high (< 26/30) or low risk (≥ 26/30) of MCI. We assessed serum Interleukin 6 (IL-6), Insulin-like Growth Factor-1 (IGF-1), and Kynurenine (KYN) levels. Cognitive measurement consisted of and four subtests of Automated Neuropsychological Assessment Metrics (ANAM), the two-choice reaction time, go/no-go, mathematical processing, and memory search test. Results Twelve weeks of RT improved Go/No-go test results in older adults with high MCI risk. RT did not significantly affect blood biomarkers. However, IGF-1 level increases were associated with improvements in response time on the mathematical processing test in the exercise group, and IL-6 level increases were associated with improvements in response time on the memory search test in the total group of participants. Finally, KYN levels significantly differed between older adults with low and high MCI risk but no significant associations with performance were found. Conclusion Our study results suggest a different effect of RT on inhibitory control between older adults with low compared to high MCI risk. IGF-1 may play a role in the mechanism behind the cognitive benefit of RT and KYN may be a surrogate biomarker for neurodegeneration and cognitive decline.

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Influence of different modes of exercise training on inflammatory markers in older adults with and without chronic diseases: A systematic review and meta-analysis

Cited by 11 publications

References 94 publications

Effectiveness of resistance training in modulating inflammatory biomarkers among Asian patients with sarcopenia: a systematic review and meta-analysis of randomized controlled trials

Effectiveness of resistance training in modulating inflammatory biomarkers among Asian patients with sarcopenia: a systematic review and meta-analysis of randomized controlled trials

Inflammatory pathway communication with skeletal muscle—Does aging play a role? A topical review of the current evidence

Resistance training's impact on blood biomarkers and cognitive function in older adults with low and high risk of mild cognitive impairment: a randomized controlled trial

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