Influence of Different Solvent Properties and Composition for the Solubility of Iopromide

Abstract

This work is to research the influence of different solvent properties and the composition on the solubility of iopromide. The solubility values of iopromide in some pure and binary solvent mixtures have been measured from T = 273.15 to 318.15 K. The result showed that the solubility obtained a maximum value in mole fraction (x = 55.426 × 10–4 at T = 318.15 K) in pure N,N-dimethylformamide (DMF) and the minimum data (x = 9.9 × 10–6 at T = 273.15 K) in neat toluene. The values in pure solvents obeyed the following order: DMF > methanol > ethanol > isopropyl alcohol > acetone > ethyl acetate > toluene. In mixed solvents, it was increased with increasing mass fraction of DMF at a given temperature. Moreover, the obtained solubility data in pure solvents were correlated with the modified Apelblat equation, and three cosolvent models (the Jouyban–Acree model, the Apelblat–Jouyban–Acree model, and CNIBS/R-K model) were applied to correlate solubility in the binary mixture. The maximum values of relative average deviation for back-calculation of iopromide in studied mixtures varied from 0.08 to 4.52%. Correlation coefficient values all approximately equal 1, which indicates that these models were very consistent with the experimental values. Furthermore, the results of powder X-ray diffraction indicate that there is no polymorph transformation or solvate formation during the solubility determination.

Solubility and Thermodynamic Modeling of Sulfanilamide in 12 Mono Solvents and 4 Binary Solvent Mixtures from 278.15 to 318.15 K

“…Considering molecular interactions into account based on the two-body and three-body interaction mixing rule, the Jouyban–Acree model was developed by Jouyban and co-workers for the improvement of cosolvent models. , It is a mathematical representation of solubilities of solute in binary mixed solvents. As shown in eq , it is the most accurate model among the available cosolvency model, which can describe the solubility and is a function of temperature and solvent composition for binary solvent mixtures. , …”

“…The Apelblat–Jouyban–Acree equation is a semiempirical model employed to correlate the solubility of a solute against the solvent composition at the same time absolute temperature and described in eq . This model is developed by combining eq and eq . ,− Here A 1 , B 1 , C 1 , A 2 , B 2 , C 2 , and J i are the model parameters of the Apelblat–Jouyban–Acree model.…”

“…As shown in eq 9, it is the most accurate model among the available cosolvency model, which can describe the solubility and is a function of temperature and solvent composition for binary solvent mixtures. 29,30 Exp represents the experimental mole fraction solubility of sulfanilamide in acetone + ethyl acetate binary mixture; eq 5 cal , eq 10 cal , eq 11 cal , and eq 12 cal are the calculated solubility by modified Apelblat, van't Hoff−Jouyban−Acree, Apelblat−Jouyban−Acree, and CNIBS/R−K models, respectively. Solvent mixtures were prepared by mixing different masses of the solvents with relative standard uncertainty u r (w) = 0.003; w represents the mass fraction of acetone in mixed solvents.…”

Solubility and Model Correlation of Amprolium Hydrochloride in Pure Solvent at the Temperature Range of 273.15–313.15 K

“…In this work, the solubility of amprolium hydrochloride in methanol, ethanol, n -propanol, isopropanol, n -butanol, i -butanol, n -octanol, acetone, ethyl acetate, 1,4-dioxane, acetonitrile, and cyclohexanone was determined by the isothermal saturation method. − The reliability of the experimental apparatus has been verified in our previous work …”

“…10−13 The reliability of the experimental apparatus has been verified in our previous work. 14 Excess amprolium hydrochloride and about 30 mL of solvents were added to the glass vessel with a reflux condenser.…”