Influence of different types of electromagnetic fields on skin reparatory processes in experimental animals

Abstract

Wound healing is a very complex process, some phases of which have only recently been explained. Magnetic and electromagnetic fields can modulate this process in a non-thermal way. The aim of this research was to compare the influence of constant and pulsed electromagnetic fields and low-level laser therapy (LLLT) on wound healing in experimental animals. The experiment was conducted on 120 laboratory rats divided into four groups of 30 animals each (constant electromagnetic field, pulsed electromagnetic field, LLLT and control group). It lasted for 21 days. Under the influence of the constant electromagnetic field the healing of the skin defect was accelerated in comparison with the control group. The difference was statistically significant in all the weeks of the experiment at the P < 0.01 level. Accelerated healing was also observed under the influence of the pulsed electromagnetic field (P < 0.05). In the group of animals exposed to LLLT, the healing of the skin defect was faster than in the control group. The statistical significance was at the P < 0.05 level. Different types of electromagnetic fields have a promoting effect on the wound healing process.

Low-Level Laser Therapy with a Pulsed Infrared Laser Accelerates Second-Degree Burn Healing in Rat: A Clinical and Microbiologic Study

“…Wounds that are not debrided, such as wounds in the current study, may not allow the maximal amount of light to reach the tissue. Our results suggest that pulsed LLLT at a dosage of 11.7 J/cm 2 produces a significant increase in the wound-closure rate and confirms the findings of Matic et al 24 that pulsed LLLT significantly accelerated the wound-closure rate of a surgically induced cutaneous wound. Whereas the results of present study and of the study of Matic et al confirmed the positive effect of pulsed LLLT on burns and acute skin wounds, other studies failed to show a positive effect of pulsed LLLT on the impaired wound-healing process.…”

“…They concluded that electrical current and laser treatment both have beneficial effects during the inflammation, proliferation, and maturation phases of a wound. More recently, Matic et al 24 made a rectangular defect of all skin layers at the dorsal part of the rat neck under general anesthesia. They used an 890-nm wavelength of the semiconductor laser.…”

“…Conversely, several studies reported the effects of pulsed diode lasers on skin-wound healing. [22][23][24] Al-Watban and Zhang 22 evaluated the effects of pulsed continuous wave (PCW) and detected the role of wound healing in rats by using both pulsed and CW LLLT. They reported that the percentage of relative wound healing was 4.32 in 100 Hz, 3.21 in 200 Hz, 3.83 in 300 Hz, 2.22 in 400 Hz,1.73 in 500 Hz, and 4.81 in CW.…”

Effects of 780-nm Low-Level Laser Therapy with a Pulsed Gallium Aluminum Arsenide Laser on the Healing of a Surgically Induced Open Skin Wound of Rat

“…31 It seems that the patients' wounds can be categorized as acute wounds. The results of the current study support the recent findings of the studies of Matic and colleagues 11 and Simunovic and colleeagues. 31 A biomechanical examination of the present study revealed that maximum stress of laser-treated wounds was significantly higher than that of the sham-exposed group on days 4 and 15.…”

“…[28][29][30] Very recently, Matic and colleagues have reported LLLT that using an 830-nm wavelength of the semiconductor laser with a frequency of 1500 Hz, impulse duration of 300 ns, and medium strength of 15.4 mW produces a significant accelerated rate of wound closure of a rectangular acute wound of all skin layers. 11 Simunovic and colleagues 31 performed a clinical study on patients with musculoskeletal disorders. All patients had surgical procedure prior to LLLT.…”