Influence of diimine bidentate ligand in the nitrosyl and nitro terpyridine ruthenium complex on the HSA/DNA interaction and antiviral activity

From Intercalation to External Binding: Ru(II) Complexes with a Spiro Ligand for TAR RNA Selective Binding and HIV-1 Reverse Transcriptase Inhibition

“…Ru­(II) DNA intercalators, represented by [Ru­(bpy) 2 (dppz)] 2+ ( DZ , bpy = 2,2′-bipyridine; dppz = dipyrido­[3,2- a :2′,3′- c ]­phenazine; Figure a) and [Ru­(bpy) 2 (pip)] 2+ (pip = 2-(phenyl)­imidazo­[4,5- f ]­[1,10]­phenanthroline), have long been employed in DNA light switches, nucleic acid-related fluorescence probes, enzyme inhibitors, and antibacterial and antitumor agents. − Their antitumor mechanisms involve traditional chemotherapy and novel therapy including photodynamic, photothermal, chemodynamic, photoactivated chemotherapy, and immunogenic cell death, either alone or in combination. − However, research on Ru­(II)-based antiviral agents is very rare. − …”