Influence of Diosmin Treatment on the Level of Oxidative Stress Markers in Patients with Chronic Venous Insufficiency

Abstract

Oxidative stress plays an important role in the pathophysiology of many human disorders, while antioxidants prevent the development of various adverse symptoms. Diosmin is a natural flavonoid applied in vascular system disorders, especially in chronic venous insufficiency (CVI), and it plays a significant part in the alleviation of CVI symptoms. Due to antioxidant activity, it also has the ability to scavenge the oxygen free radicals and hence decreases the level of oxidative stress biomarkers, such as prostaglandins and their precursors—isoprostanes. In the study, the influence of diosmin treatment on the level of isoprostanes in plasma samples of patients suffering from CVI was examined. The qualitative analysis was performed using high-performance liquid chromatography with spectrometry detection (LC-MS). The statistically significant decrease of isoprostane content after 3 months of treatment was observed within the studied group; however, the most significant changes were observed in patients who smoke.

Diosmin for the prevention of ovarian hyperstimulation syndrome

“…It can increase venous tension during acidosis. It also has a specific affinity for veins and does not affect the arterial system; it therefore serves as a targeted therapy for capillary leak syndrome and increased vascular permeability among women with OHSS …”

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“…Development of endothelial dysfunction in experimental animals and also extent of its correction by the studied drug estimated on the settlement coefficient of endothelial dysfunction (CED). [7] The aggregation of thrombocytes (AT) was investigated by a visual micromethod with use as inductors ADF, a collagen, thrombinum, ristomycinum, and an adrenaline.…”

“…Diosmin has the wide range of biological effects which are confirmed with numerous researches including renders antioxidatic, anti-inflammatory, antimutagen, and antiulcerous action. [7] At the same time in a question of effective use of drugs of a diosmin, the bioavailability comes to the forefront. A number of studies have shown that micronized diosmin is superior to the rate of absorption and excretion of nonmicronized analog, which led to improved clinical effect.…”

The role of rutin and diosmin, two citrus polyhydroxyflavones in disease prevention and treatment

“…As compared to rutin and quercetin, lesser scientific research has been conducted on diosmin, but in several cell-based, animal and clinical settings, a wide range of biological activities were demonstrated for diosmin or diosmetin (Dumon et al, 1994;Feldo et al, 2018;Hasan et al, 2017;Senthamizhselvan et al, 2014;Shalkami et al, 2018;Silambarasan and Raja, 2012) (See Table 1 for antidisease effects of diosmin and diosmetin). Most of the bioactivities of diosmin are based on strong antioxidant effects on levels of free radical scavenger activity to reduce oxidative stress.…”

“…Anti-inflammatory and anti-apoptotic effects by diosmin are also believed to decrease hypertension thus leading to an improvement of vascular problems. Treatment of patients with chronic venous insufficiency (CVI) with diosmin decreased free radical-induced cell damage and showed beneficial effects such as increased lymphatic drainage, microcirculation, capillary resistance, vascular tonus, and vein elasticity (Batchvarov et al, 2010;Feldo et al, 2018;Perrin and Ramelet, 2011). Noteworthy, the most significant changes in the alleviation of these CVI symptoms by diosmin were observed in smoker patients (Feldo et al, 2018).…”