Influence of dioxin exposure upon levels of prostate-specific antigen and steroid hormones in Vietnamese men

Sun, Xian; Kido, Teruhiko; Honma, Sato; Okamoto, Rie; Manh, Ho Dung; Maruzeni, Shoko; Nishijo, Muneko; Nakagawa, Hideaki; Nakano, Takeshi; Koh, Eitetsu; Takasuga, Takumi; Nhu, Dang Duc; Hưng, Nguyễn Ngọc; Son, Le Ke

doi:10.1007/s11356-015-5931-3

Cited by 9 publications

(5 citation statements)

References 30 publications

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“…As before, there was also no effect related to cortisol in the longitudinal analyses. The results of this study confirmed previous studies that also found a positive association between PCB exposure and DHEAS concentration, but none between PCB exposure and cortisol concentration [2,15,16].…”

Section: Discussionsupporting

confidence: 91%

“…However, a subsequent study found a positive association between PCB exposure and the DHEAS concentration in male employees [ 2 ]. Sun et al also report a significant increase in DHEA concentration with increased PCB body burden in men [ 16 ]. High DHEAS inhibits genetically programmed cell death [ 17 ], and this enhances the risk for cancer.…”

Section: Introductionmentioning

confidence: 99%

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Cross-Sectional and Longitudinal Effects of PCB Exposure on Human Stress Hormones in the German HELPcB Surveillance Program

Gaum

Vida

Schettgen

et al. 2020

IJERPH

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Multiple pathological associations are attributed to PCBs (polychlorinated biphenyls). Research shows a positive association of PCBs with dehydroepiandrosterone sulfate (DHEAS) concentration but the results on the stress hormone cortisol have been inconsistent so far. This study is the first to examine not only the cross-sectional but also the longitudinal effects of PCB exposure on the stress hormones DHEAS and cortisol. Over a period of three years, 112 former employees occupationally exposed to PCBs were tested for their body burden with different types of PCBs (lower and higher chlorinated, dioxin-like and hydroxylated) and for their stress hormone concentration. Highly exposed employees showed a significantly higher risk for higher DHEAS values. Multiple linear regression analysis revealed a positive relationship between the exposure to lower chlorinated PCBs and DHEAS. Mixed models also revealed a significantly positive correlation between lower chlorinated PCBs with DHEAS when controlled for a cross-section. However, an effect for cortisol was not found. These results suggest a causal pathophysiological relationship between PCB exposure and DHEAS concentration, but not with cortisol. The health consequences of high DHEAS concentrations are discussed.

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Section: Discussionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Cross-Sectional and Longitudinal Effects of PCB Exposure on Human Stress Hormones in the German HELPcB Surveillance Program

Gaum

Vida

Schettgen

et al. 2020

IJERPH

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“…A study of men living in areas of Vietnam with high dioxin contamination found no difference in prostate-specific antigen concentrations between control and high serum dioxin groups [47]. Also, the Vietnamese men with high serum dioxin showed increased testosterone and estradiol levels, but decreased dehydroepiandrosterone levels, and no change in other steroid hormones [48]. Exposure to dioxin-contaminated food was associated with a decrease in total and free testosterone [49], although (as noted above) several studies have not found TCDD exposure to alter semen quality or sperm count (reviewed in [50]).…”

Section: Discussionmentioning

confidence: 99%

Serum dioxin and DNA methylation in the sperm of operation ranch hand veterans exposed to Agent Orange

et al. 2019

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BackgroundExposure to the herbicide Agent Orange during the Vietnam War was widespread and is associated with numerous adverse health outcomes. A continuing concern of veterans is the possibility that exposure to the dioxin-containing herbicide might induce adverse reproductive outcomes. We sought to assess whether exposure to Agent Orange in Vietnam was associated with changes in DNA methylation in sperm in a subset of Vietnam veterans who participated in the Air Force Health Study (AFHS).MethodsWe studied 37 members of the AFHS chosen to have no, low, medium or high exposure to Agent Orange, based upon serum dioxin levels obtained during a series of examinations. DNA from stored semen was extracted and DNA methylation assessed on the Illumina 450 K platform.ResultsInitial epigenome-wide analysis returned no loci that survived control for false discovery. However, the TEAD3 gene had four different CpG sites that showed loss of DNA methylation associated with dioxin exposure. Analysis assessing regional DNA methylation changes revealed 36 gene regions, including the region of the imprinted gene H19 to have altered DNA methylation associated with high exposure compared to the low exposure group. Additional comparison of our data with sperm DNA methylation data from Russian boys exposed to dioxin found an additional 5 loci that were altered in both studies and exhibited a consistent direction of association.ConclusionsStudying a small number of sperm samples from veterans enrolled in the AFHS, we did not find evidence of significant epigenome-wide alterations associated with exposure to Agent Orange. However, additional analysis showed that the H19 gene region is altered in the sperm of Agent Orange-exposed Ranch Hand veterans. Our study also replicated several findings of a prior study of dioxin-exposed Russian boys. These results provide additional candidate loci for further investigation and may have implications for the reproductive health of dioxin-exposed individuals.

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“…Among the output studies, two studies examined PCBs in food and did not measure their levels in serum and plasma (Ali et al, 2016; Pavuk et al, 2004). In three studies, prostate antigen levels and carcinogenic biomarkers were measured and no cancer incidence was reported (De Coster et al, 2008; Hardell et al, 2006; Sun et al, 2016). One study examined the association between PCBs and mortality from prostate cancer (Fernandez-Navarro et al, 2017).…”

Section: Resultsmentioning

confidence: 99%

Meta-Analysis of Body Concentration of Polychlorinated Biphenyls and Prostate Cancer

et al. 2022

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Prostate Cancer (PCa) is the second most common hormone-sensitive neoplasm among men and the fifth cause of death due to malignancy in developed countries. Moreover, studies have shown the links between polychlorinated biphenyls (PCBs) and hormone-related cancers such as prostate cancer. Hence, we conducted a systematic review and meta-analysis to evaluate the potential relationship between the PCBs and developing PCa. In this meta-analysis study, the relevant databases such as Web of Science, PubMed, and Scopus were studied for English research. The Newcastle–Ottawa Scale was applied to evaluate the quality of the selected publications. The GRADE method was used to assess the risk of bias studies. After reviewing the relevant studies, a cohort and seven case–control studies entered the meta-analysis. These articles were published during 2003–2021 with 2989 participants and 1212 PCa cases. The heterogeneity among the studies was significant ( p = 0.001, I2 = 70.61). Using a random-effects model, the association between the serum and plasma levels of PCBs and the risk of PCa was not shown to be significant (OR = 1.12; 95% CI: 0.90–1.39). The results of Egger’s test showed no trace of publication bias in the studies (P of bias = 0.573). This systematic review and meta-analysis was presented based on relatively strong evidence and has confirmed negatively significant associations between PCa risk and some PCBs congeners (PCB 44, 52, and 101). This study does not provide strong evidence that total PCB exposure is a risk factor for PCa development in humans.

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Influence of dioxin exposure upon levels of prostate-specific antigen and steroid hormones in Vietnamese men

Cited by 9 publications

References 30 publications

Cross-Sectional and Longitudinal Effects of PCB Exposure on Human Stress Hormones in the German HELPcB Surveillance Program

Cross-Sectional and Longitudinal Effects of PCB Exposure on Human Stress Hormones in the German HELPcB Surveillance Program

Serum dioxin and DNA methylation in the sperm of operation ranch hand veterans exposed to Agent Orange

Meta-Analysis of Body Concentration of Polychlorinated Biphenyls and Prostate Cancer

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