Influence of Disease Activity in Rheumatoid Arthritis on Radiographic Progression of Concomitant Interphalangeal Joint Osteoarthritis

Lechtenboehmer, Christian A.; Jaeger, Veronika K.; Kyburz, Diego; Walker, Ulrich A.; Hügle, Thomas

doi:10.1002/art.40684

Cited by 6 publications

(8 citation statements)

References 17 publications

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“…In our cohort, EHOA showed no association with Rheumatoid Factor (RF). These results are consistent with previous publications 40 – 42 , and similarly, there is no observed relationship between EHOA and Anti-Cyclic Citrullinated Peptide antibodies (ACPA), a novel finding not reported before in our knowledge. However, there are existing data about the connection between ACPA and inflammatory hand OA 43 .…”

Section: Discussionsupporting

confidence: 94%

Metabolic syndrome is not associated with erosive hand osteoarthritis: a cross-sectional study using data from the PROCOAC cohort

Silva-Díaz,

Pértega-Díaz,

Balboa-Barreiro

et al. 2024

Sci Rep

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To delineate the phenotype of erosive hand osteoarthritis (EHOA) in a Spanish population and assess its correlation with metabolic syndrome. We conducted a cross-sectional study using baseline data from the Prospective Cohort of Osteoarthritis from A Coruña (PROCOAC). Demographic and clinical variables, obtained through questionnaires, clinical examinations, and patient analytics, were compared among individuals with hand OA, with and without EHOA. We performed appropriate univariate and multivariate stepwise regression analyses using SPSS v28. Among 1039 subjects diagnosed with hand OA, 303 exhibited EHOA. Multivariate logistic regression analysis revealed associations with inflamed joints, nodular hand OA, and total AUSCAN. Furthermore, the association with a lower prevalence of knee OA remained significant. The influence of metabolic syndrome (MetS) on EHOA patients was analyzed by including MetS as a covariate in the model. It was observed that MetS does not significantly impact the presence of EHOA, maintaining the effect size of other factors. In conclusion, in the PROCOAC cohort, EHOA is associated with nodular hand OA, inflammatory hand OA, and a higher total AUSCAN. However, EHOA is linked to a lower prevalence of knee OA. Importantly, in our cohort, no relationship was found between EHOA and MetS.

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Section: Discussionsupporting

confidence: 94%

Metabolic syndrome is not associated with erosive hand osteoarthritis: a cross-sectional study using data from the PROCOAC cohort

Silva-Díaz,

Pértega-Díaz,

Balboa-Barreiro

et al. 2024

Sci Rep

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“…Three meta-analyses329–331 and 61 observational studies92 332–391 assessed the relationship between body weight and outcomes in RA. Higher weight was associated with worse pain,329 354 361 362 380 function,329 336 344 362 disease activity,329 330 336 338 339 342 344 347 357 361–363 366 384 389 and fatigue,351 as well as more comorbidities 331 355 360 365 374 390.…”

Section: Resultsmentioning

confidence: 99%

Effects of physical exercise and body weight on disease-specific outcomes of people with rheumatic and musculoskeletal diseases (RMDs): systematic reviews and meta-analyses informing the 2021 EULAR recommendations for lifestyle improvements in people with RMDs

et al. 2022

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BackgroundA European League Against Rheumatism (EULAR) taskforce was convened to develop recommendations for lifestyle behaviours in rheumatic and musculoskeletal diseases (RMDs). This paper reviews the literature on the effects of physical exercise and body weight on disease-specific outcomes of people with RMDs.MethodsThree systematic reviews were conducted to summarise evidence related to exercise and weight in seven RMDs: osteoarthritis, rheumatoid arthritis, systemic lupus erythematosus, axial spondyloarthritis (axSpA), psoriatic arthritis, systemic sclerosis and gout. Systematic reviews and original studies were included if they assessed exercise or weight in one of the above RMDs, and reported results regarding disease-specific outcomes (eg, pain, function, joint damage). Systematic reviews were only included if published between 2013–2018. Search strategies were implemented in the Medline, Embase, Cochrane Library of systematic reviews and CENTRAL databases.Results236 articles on exercise and 181 articles on weight were included. Exercise interventions resulted in improvements in outcomes such as pain and function across all the RMDs, although the size of the effect varied by RMD and intervention. Disease activity was not influenced by exercise, other than in axSpA. Increased body weight was associated with worse outcomes for the majority of RMDs and outcomes assessed. In general, study quality was moderate for the literature on exercise and body weight in RMDs, although there was large heterogeneity between studies.ConclusionThe current literature supports recommending exercise and the maintenance of a healthy body weight for people with RMDs.

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“…First, the NinJa database does not contain clinical data related to comorbidities, making it impossible to exclude the coexistence of RA with other rheumatic diseases, such as OA and PsA, in some patients. Previous studies have indeed demonstrated that OA can complicate RA, particularly in older adults [ 28 , 29 , 30 ]. In a cross-sectional analysis of 1988 patients with RA, Lechtenboehmer et al demonstrated that radiographic DIP joint OA is present in up to 60% of patients, and that it is significantly associated with age, the female sex, and body mass index, but not with RA disease activity [ 30 ].…”

Section: Discussionmentioning

confidence: 98%

“…Previous studies have indeed demonstrated that OA can complicate RA, particularly in older adults [ 28 , 29 , 30 ]. In a cross-sectional analysis of 1988 patients with RA, Lechtenboehmer et al demonstrated that radiographic DIP joint OA is present in up to 60% of patients, and that it is significantly associated with age, the female sex, and body mass index, but not with RA disease activity [ 30 ]. Regarding the location of affected DIP joints in OA, Rees et al demonstrated that the DIP joint of the index finger is most frequently affected, while the ring finger is relatively spared in patients with hand OA [ 31 ].…”

Section: Discussionmentioning

confidence: 98%

Distal Interphalangeal Joint Involvement May Be Associated with Disease Activity and Affected Joint Distribution in Rheumatoid Arthritis

Mizuuchi

Sawada

Nishiyama

et al. 2022

JCM

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We investigated the relationship between distal interphalangeal (DIP) joint involvement and disease activity in 10,038 patients with adult-onset rheumatoid arthritis (RA). The affected joint distribution was investigated using the joint indices (JI) x, y, and z, corresponding to the upper and lower joints, and the predominance of large-joint involvement, respectively. DIP joint involvement (defined by the presence of tenderness and/or swelling in DIP joints) was present in 206 (2.1%) of 10,038 patients with RA. Patients with RA exhibiting DIP joint involvement were significantly younger, and more frequently women. DIP joint involvement was positively associated with Disease Activity Score-28 using C-reactive protein, and clinical variables related to high RA disease activity, including JIs x and y, and was negatively associated with JI z. JI x was significantly higher than JI y in RA patients with DIP joint involvement. An odds ratio analysis revealed that small-to-medium sized and upper-extremity joints ranked first, second, and fourth among the eight variables significantly associated with DIP joint involvement. The correlation coefficients revealed that small-sized and upper-extremity joints ranked first and second among the five significant variables. DIP joint involvement, albeit rare, is significantly associated with high RA disease activity with predominance of small-sized and upper-extremity joints.

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Influence of Disease Activity in Rheumatoid Arthritis on Radiographic Progression of Concomitant Interphalangeal Joint Osteoarthritis

Cited by 6 publications

References 17 publications

Metabolic syndrome is not associated with erosive hand osteoarthritis: a cross-sectional study using data from the PROCOAC cohort

Metabolic syndrome is not associated with erosive hand osteoarthritis: a cross-sectional study using data from the PROCOAC cohort

Effects of physical exercise and body weight on disease-specific outcomes of people with rheumatic and musculoskeletal diseases (RMDs): systematic reviews and meta-analyses informing the 2021 EULAR recommendations for lifestyle improvements in people with RMDs

Distal Interphalangeal Joint Involvement May Be Associated with Disease Activity and Affected Joint Distribution in Rheumatoid Arthritis

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