Influence of Disease Duration on Visual Evoked Potentials in Migraineurs

Yücesan, Canan; Şener, Özden; Mutluer, Nermin

doi:10.1046/j.1526-4610.2000.00058.x

Cited by 12 publications

(10 citation statements)

References 18 publications

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“…The amplitudes of the major positive waves of the VEP were shown to be greater in migraneurs between attacks than in the age and sex-matched controls, suggesting hyperexcitability in the visual pathways in migraneurs (23). On the other hand, some other studies failed to show differences in VEP latencies and amplitudes between migraneurs and healthy controls (24,25). The discrepancies between the studies are possibly due to differences in the time of measurements with regard to attacks, as it is known that cortical excitability changes with duration of the headache-free period and normalizes before the next migraine attack (26).…”

Section: Discussionmentioning

confidence: 99%

Coupling between Visual Evoked Cerebral Blood Flow Velocity Responses and Visual Evoked Potentials in Migraneurs

Zaletel¹,

Štrucl

Bajrović

et al. 2005

Cephalalgia

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Neurovascular coupling may be altered in migraneurs. Therefore, visual evoked potentials (VEP) and visually evoked cerebral blood flow velocity responses (VEFR) were simultaneously recorded in 30 healthy controls and 30 migraneurs interictally using a checkerboard stimulus with visual contrasts of 1%, 10% and 100%. The VEFR were measured in the posterior cerebral artery using transcranial Doppler and VEP were recorded from occipital leads. We found an increase in VEFR and VEP in both the healthy and migraneur groups (P < 0.01). VEFR were significantly higher in migraneurs (P < 0.01), while VEP did not significantly differ between the groups (P > 0.05). Regression showed a significant association between VEP and VEFR in both healthy controls (r = 0.66, P < 0.01) and migraneurs (r = 0.63, P < 0.01). The regression coefficient of migraneurs (b = 0.88, SE = 0.08) was significantly higher than that of healthy controls (b = 0.55, SE = 0.07) (P = 0.04). We conclude that neurovascular coupling is increased in migraneurs interictally.

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Section: Discussionmentioning

confidence: 99%

Coupling between Visual Evoked Cerebral Blood Flow Velocity Responses and Visual Evoked Potentials in Migraneurs

Zaletel¹,

Štrucl

Bajrović

et al. 2005

Cephalalgia

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“…The common migraine phenotypes are heterogeneous and appear to be complex genetic disorders in which susceptibility genes and environmental factors interact (1–5). Both neuronal and vascular components are relevant in migraine pathophysiology and probably inter‐related (6–9). The neuronal structures involved are the cerebral cortex, the brainstem (periaqueductal grey matter, aminergic nuclei), and both peripheral and central components of the trigeminovascular system.…”

Section: Introductionmentioning

confidence: 99%

Electrophysiological Studies in Migraine: A Comprehensive Review of Their Interest and Limitations

et al. 2003

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Electrophysiological methods may help to unravel some of the pathophysiological mechanisms of migraine. Lack of habituation is the principal and most reproducible interictal abnormality in sensory processing in migraineurs. It is found in evoked potential (EP) studies for every stimulation modality including nociceptive stimuli, and it is likely to be responsible for the increased intensity dependence of EP. We have hypothesized that deficient EP habituation in migraine could be due to a reduced preactivation level of sensory cortices because of hypofunctioning subcortico-cortical aminergic pathways. This is not in keeping with simple hyperexcitability of the cortex, which has been suggested by some, but not all, studies of transcranial magnetic stimulation (TMS). A recent study of the effects of repetitive TMS on visual EP strongly supports the hypothesis that migraine is characterized by interictal cortical hypoexcitability. With regard to pain mechanisms in migraine, electrophysiological studies of trigeminal pathways using nociceptive blink and corneal reflexes have confirmed that sensitization of central trigeminal nociceptors occurs during migraine attacks.

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“…The available published data on VEP studies in migraine are presented in Table 1, including the methods used in each study (5–44). The table illustrates the great variability of methods.…”

Section: Visual Evoked Potentials (Vep) D Magis and J Schoenenmentioning

confidence: 99%

“… Luminance: a change in luminance interferes with peak amplitudes and latencies. Band pass filtering: it should ideally be minimal in habituation studies. Spatial frequency 1°8′ is recommended Stimulation frequency: this is important as higher stimulation rates induce faster habituation; 3.1 Hz can be recommended. Number of blocks of averaging: the optimal number of blocks has to be defined; usually five or six blocks of 50–100 averaging are used. We recommend recording evoked potentials continuously and averaging off‐line, which allows measurement of habituation on blocks of a variable number of responses without stimulus interruption. The time interval between the recording session and the last/next attack is crucial as habituation markedly changes in the peri‐attack interval (33); an interval of at least 72 h is recommended, which indicates that patients with high attack frequencies have to be studied separately. …”

Section: Visual Evoked Potentials (Vep) D Magis and J Schoenenmentioning

confidence: 99%

Evaluation and Proposal for Optimalization of Neurophysiological Tests in Migraine: Part 1—Electrophysiological Tests

et al. 2007

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Neurophysiological testing has become a valuable tool for investigating brain excitability and nociceptive systems in headache disorders. Previous reviews have suggested that most neurophysiological tests have limited value for headache diagnosis, but a vast potential for exploring the pathophysiology of headaches, the central effects of certain pharmacological treatments and phenotype-genotype correlations. Many protocols, however, lack standardization. This meta-analytical review of neurophysiological methods in migraine was initiated by a task force within the EUROHEAD project (EU Strep LSHM-CT-2004-5044837-Workpackage 9). Most of the neurophysiological approaches that have been used in headache patients are reviewed, i.e. evoked potentials, nociception-specific blink reflex, single-fibre electromyography, neuroimaging methods (functional MRI, PET, and voxel-based morphometry) and the nitroglycerin attack-provoking test. For each of them, we summarize the results, analyse the methodological limitations and propose recommendations for improved methodology and standardization of research protocols. The first part is devoted to electrophysiological methods, the second to neuroimaging techniques and the NTG test.

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Influence of Disease Duration on Visual Evoked Potentials in Migraineurs

Abstract: It was concluded that the duration of migraine has no influence on pattern-reversal visual evoked potentials and that the pathogenesis of early- and late-onset migraine may be different.

Cited by 12 publications

References 18 publications

Coupling between Visual Evoked Cerebral Blood Flow Velocity Responses and Visual Evoked Potentials in Migraneurs

Coupling between Visual Evoked Cerebral Blood Flow Velocity Responses and Visual Evoked Potentials in Migraneurs

Electrophysiological Studies in Migraine: A Comprehensive Review of Their Interest and Limitations

Evaluation and Proposal for Optimalization of Neurophysiological Tests in Migraine: Part 1—Electrophysiological Tests

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